| HepaticIschemia/Reperfusion Injuryinvolves functional tryptase/PAR-2 signaling in liver sinusoidal endothelial cell population. | HepaticIschemia/Reperfusion Injuryinvolves functional tryptase/PAR-2 signaling in liver sinusoidal endothelial cell population.
Song J, He Z, Yang M, Yu T, Wang X, Liu B, Li J. | 02/12/2022 |
| Protective role of mouse mast cell tryptase Mcpt6 in melanoma. | Protective role of mouse mast cell tryptase Mcpt6 in melanoma.
Grujic M, Hellman L, Gustafson AM, Akula S, Melo FR, Pejler G., Free PMC Article | 06/5/2021 |
| High MCP6 expression is associated with small bowel cancer. | Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.
Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K., Free PMC Article | 07/28/2018 |
| These data indicate that endogenous mMCP6 has scar-suppressing properties after spinal cord injury via indirect cleavage of axon growth-inhibitory scar components and alteration of the gene expression profile of these factors. | Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6.
Vangansewinkel T, Geurts N, Quanten K, Nelissen S, Lemmens S, Geboes L, Dooley D, Vidal PM, Pejler G, Hendrix S. | 08/19/2017 |
| Inflammatory Th2 responses can develop independently of MCP-6, whereas MCP-6 plays a key role in the development of airway hyperresponsiveness. | Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma.
Cui Y, Dahlin JS, Feinstein R, Bankova LG, Xing W, Shin K, Gurish MF, Hallgren J., Free PMC Article | 02/28/2015 |
| Tryptase-beta was capable of inducing pelvic pain and was increased in experimental autoimmune prostatitis. | Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.
Roman K, Done JD, Schaeffer AJ, Murphy SF, Thumbikat P., Free PMC Article | 02/14/2015 |
| Results suggest that mouse mast cell proteases 4, 5, and 6 are mediators of the critical role mast cells play in microdeformational wound therapy in the proliferative phase of healing. | The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy.
Succar J, Douaiher J, Lancerotto L, Li Q, Yamaguchi R, Younan G, Pejler G, Orgill DP. | 12/20/2014 |
| Accumulated data in this review suggest that mast cells, their tryptases, and their chymases play important roles in tissue repair. | Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
Douaiher J, Succar J, Lancerotto L, Gurish MF, Orgill DP, Hamilton MJ, Krilis SA, Stevens RL., Free PMC Article | 05/17/2014 |
| mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease, has a role in proteolytic histone modification | Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease.
Melo FR, Vita F, Berent-Maoz B, Levi-Schaffer F, Zabucchi G, Pejler G., Free PMC Article | 05/17/2014 |
| Trypase can promote atherosclerotic plaque haemorrhage by promoting angiogenesis and regulating the balance of PAI-1 and tPA. | Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice.
Zhi X, Xu C, Zhang H, Tian D, Li X, Ning Y, Yin L., Free PMC Article | 10/26/2013 |
| This study demonstrates for the first time that an mast cell-restricted tetramer-forming tryptase has a prominent adverse role in experimental chronic obstructive pulmonary disease | A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.
Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM., Free PMC Article | 04/20/2013 |
| this study indicates that mast cells may be a source of TGF-beta production after cigarette smoke exposure and that in turn TGF-beta may change the tryptase expression in mast cells. | A relation between TGF-β and mast cell tryptase in experimental emphysema models.
Mortaz E, Givi ME, Da Silva CA, Folkerts G, Redegeld FA. | 10/20/2012 |
| direct participation of mast cell tryptase in the pathogenesis of experimental abdominal aortic aneurysms | Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.
Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP., Free PMC Article | 08/20/2011 |
| MCP6 actively depletes the local environment of IL-6 to maintain tolerance in mice. | Mast cell protease 6 is required for allograft tolerance.
de Vries VC, Elgueta R, Lee DM, Noelle RJ. | 02/26/2011 |
| MCP-6 (but not MCP-7) is an essential mast cell-restricted mediator in chemically induced colitis and acts upstream of many of the factors implicated in inflammatory bowel disease. | Essential role for mast cell tryptase in acute experimental colitis.
Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL., Free PMC Article | 02/26/2011 |
| Because mMCP-6 and mMCP-7 can compensate for each other in this mouse disease model, the elimination of both tryptases is necessary to reveal the prominent roles of these serine proteases in joint inflammation and destruction. | The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis.
McNeil HP, Shin K, Campbell IK, Wicks IP, Adachi R, Lee DM, Stevens RL. | 01/21/2010 |
| mast cell secretion of the tryptase mMCP-6, a function directed by the activity of the adaptive immune system, contributes to eosinophil recruitment to the site of larval infection | Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection.
Shin K, Watts GF, Oettgen HC, Friend DS, Pemberton AD, Gurish MF, Lee DM., Free PMC Article | 01/21/2010 |
| mMCP-6 has a critical immunoprotective role in bacterial infections | The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.
Thakurdas SM, Melicoff E, Sansores-Garcia L, Moreira DC, Petrova Y, Stevens RL, Adachi R. | 01/21/2010 |
| mast cell mMCP-4, -5, and -6 (chymase and tryptase) participate in the acute inflammation and remodeling process of viral myocarditis. | Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis.
Kitaura-Inenaga K, Hara M, Higuchi K, Yamamoto K, Yamaki A, Ono K, Nakano A, Kinoshita M, Sasayama S, Matsumori A. | 01/21/2010 |
| Molecular modeling of MMCP6 identified 4 conserved & exposed His residues, H35, H106, H108, & H238. These surface-exposed histidines mediate the interaction of mast cell tryptase with heparin & are critical in the formation of active tryptase tetramers. | Histidines are critical for heparin-dependent activation of mast cell tryptase.
Hallgren J, Bäckström S, Estrada S, Thuveson M, Pejler G. | 01/21/2010 |
| Gene expression is activated by the TGF-beta/activin pathway and the differential regulation by the isoforms suggest a rigorous regulation of mast cell function. | Up-regulation of mouse mast cell protease-6 gene by transforming growth factor-beta and activin in mast cell progenitors.
Funaba M, Ikeda T, Murakami M, Ogawa K, Abe M. | 01/21/2010 |
| Tryptase contained in the neurons and in the endothelial cells of the mdx mouse brain may be involved in the regulation of angiogenesis taking place in mdx mouse. | A possible role of tryptase in angiogenesis in the brain of mdx mouse, a model of Duchenne muscular dystrophy.
Nico B, Marzullo A, Corsi P, Vacca A, Roncali L, Ribatti D. | 01/21/2010 |