| The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. | The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress.
Han Z, Andrš M, Madhavan BK, Kaymak S, Sulaj A, Kender Z, Kopf S, Kihm L, Pepperkok R, Janscak P, Nawroth P, Kumar V., Free PMC Article | 08/10/2023 |
| Mcm2 promotes stem cell differentiation via its ability to bind H3-H4. | Mcm2 promotes stem cell differentiation via its ability to bind H3-H4.
Xu X, Hua X, Brown K, Ren X, Zhang Z., Free PMC Article | 12/3/2022 |
| Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context. | Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.
Matsukawa T, Yin M, Baslan T, Chung YJ, Cao D, Bertoli R, Zhu YJ, Walker RL, Freeland A, Knudsen E, Lowe SW, Meltzer PS, Aplan PD., Free PMC Article | 08/20/2022 |
| Segregation of parental histones to the leading strand increased markedly in cells with histone-binding mutations in MCM2, part of the replicative helicase, exacerbating histone posttranslational modifications sister chromatid asymmetry. | MCM2 promotes symmetric inheritance of modified histones during DNA replication.
Petryk N, Dalby M, Wenger A, Stromme CB, Strandsby A, Andersson R, Groth A. | 11/3/2018 |
| MCM2 is dynamically expressed in both proliferative and differentiated stromal cells during mouse periimplantation uterus. expression of Mcm2 is induced by progesterone action in the mouse uterine stroma. siRNA-mediated silencing of MCM2 arrests the cell cycle at G1-S transition during stromal cell proliferation. downregulation of Mcm2 could also compromise stromal cell differentiation. | MCM2 mediates progesterone-induced endometrial stromal cell proliferation and differentiation in mice.
Kong S, Han X, Cui T, Zhou C, Jiang Y, Zhang H, Wang B, Wang H, Zhang S. | 07/1/2017 |
| MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome. | Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
Kunnev D, Freeland A, Qin M, Leach RW, Wang J, Shenoy RM, Pruitt SC., Free PMC Article | 05/21/2016 |
| these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level. | Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation.
Bai G, Smolka MB, Schimenti JC., Free PMC Article | 05/14/2016 |
| Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70. | Minichromosome maintenance 2 bound with retroviral Gp70 is localized to cytoplasm and enhances DNA-damage-induced apoptosis.
Abe S, Kurata M, Suzuki S, Yamamoto K, Aisaki K, Kanno J, Kitagawa M., Free PMC Article | 12/8/2012 |
| Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma. | Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.
Rusiniak ME, Kunnev D, Freeland A, Cady GK, Pruitt SC., Free PMC Article | 11/24/2012 |
| gp70 enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus and MCM2 resulting in the activation of DNA-PK to phosphorylate P53. | A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.
Hasegawa M, Kurata M, Yamamoto K, Yoshida K, Aizawa S, Kitagawa M. | 01/21/2010 |
| Accumulation and dynamics of Mcm2 are described during oogenesis and the first embryonic cell cycle. | Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
Swiech L, Kisiel K, Czolowska R, Zientarski M, Borsuk E. | 01/21/2010 |