| Melanocortin/MC5R axis regulates the proliferation of hematopoietic stem cells in mice after ionizing radiation injury. | Melanocortin/MC5R axis regulates the proliferation of hematopoietic stem cells in mice after ionizing radiation injury.
Chen N, Quan Y, Chen M, Lu Y, Yang L, Wang S, Chen F, Xu Y, Shen M, Zeng H, Chen S, Wang F, Wang J, Hu M., Free PMC Article | 07/7/2023 |
| Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis. | Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis.
Ng TF, Manhapra A, Cluckey D, Choe Y, Vajram S, Taylor AW., Free PMC Article | 09/3/2022 |
| This report demonstrates that obesity exacerbates autoimmune uveitis and inhibits the promotion of post-experimental autoimmune uveitis regulatory immunity through the melanocortin 5 receptor. | Exacerbation of autoimmune uveitis by obesity occurs through the melanocortin 5 receptor.
Muhammad FY, Peters K, Wang D, Lee DJ., Free PMC Article | 05/30/2020 |
| Tissue-specific production of MiR-155 inhibits Mc5R-dependent suppressor macrophages to promote experimental autoimmune uveitis. | Tissue-specific production of MicroRNA-155 inhibits melanocortin 5 receptor-dependent suppressor macrophages to promote experimental autoimmune uveitis.
Muhammad F, Trivett A, Wang D, Lee DJ., Free PMC Article | 05/30/2020 |
| importance for MC5r and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients | MC5r and A2Ar Deficiencies During Experimental Autoimmune Uveitis Identifies Distinct T cell Polarization Programs and a Biphasic Regulatory Response.
Lee DJ, Preble J, Lee S, Foster CS, Taylor AW., Free PMC Article | 07/14/2018 |
| MC5r-dependent regulatory immunity increased CD11b(+)F4/80(+)Ly-6C(low)Ly-6G(+)CD39(+)CD73(+) APCs in the spleen of post-experimental autoimmune uveoretinitis mice. | Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice.
Lee DJ, Taylor AW., Free PMC Article | 12/14/2013 |
| In 3T3-L1 adipocytes, alpha-MSH-activated MC5-R signals through the cAMP/PKA and MAPK/ERK1/2 pathways. | Alpha-MSH signalling via melanocortin 5 receptor promotes lipolysis and impairs re-esterification in adipocytes.
Rodrigues AR, Almeida H, Gouveia AM. | 11/16/2013 |
| Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice. | Melanocortin receptors 1 and 5 might mediate inhibitory effects of α-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
Etori M, Yonekubo K, Sato E, Mizukami K, Hirahara K, Karasuyama H, Maeda H, Yamashita M. | 08/25/2012 |
| Dependence on MC5r expression promotes or selectively activates IRBP-specific FoxP3+ TGF-beta+ CD25+CD4+ Treg cells in the spleens of experimental uveitis-recovered mice. | Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen.
Lee DJ, Taylor AW., Free PMC Article | 01/14/2012 |
| melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes | Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved.
Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS. | 12/10/2011 |
| Data show that melanocortins regulate Il6 gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5. | Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes.
Jun DJ, Na KY, Kim W, Kwak D, Kwon EJ, Yoon JH, Yea K, Lee H, Kim J, Suh PG, Ryu SH, Kim KT., Free PMC Article | 06/14/2010 |
| The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor. | Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.
Sebag JA, Hinkle PM., Free PMC Article | 01/21/2010 |
| causes excretion of urinary pheromones that delay aggressive responses by other males | Disruption of the fifth melanocortin receptor alters the urinary excretion of aggression-modifying pheromones in male house mice.
Caldwell HK, Lepri JJ. | 01/21/2010 |