| Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex. | Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex.
Saha S, Jungas TT, Ohayon D, Audouard C, Ye T, Fawal MA, Davy A. | 09/13/2023 |
| Evolutionary adaptation of DHFR via expression of enzyme isoforms with various binding properties and dynamics behavior: a bioinformatics and computational study. | Evolutionary adaptation of DHFR via expression of enzyme isoforms with various binding properties and dynamics behavior: a bioinformatics and computational study.
Karimi E, Heshmati E, Khalifeh K. | 06/11/2022 |
| Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase. | Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase.
Li J, Lin J, Kohen A, Singh P, Francis K, Cheatum CM., Free PMC Article | 01/8/2022 |
| A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population. | A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population.
Li B, Li Y, Xu S, Chen H, Dai S, Peng X, Wang L, Liang Y, Li C, Tang B, Zhu L, Zhang T, Lv C, Wang C, Han L., Free PMC Article | 11/6/2021 |
| Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer. | Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
De Castro TB, Rodrigues-Fleming GH, Oliveira-Cucolo JG, Silva JNGD, Silva FP, Raposo LS, Maniglia JV, Pavarino EC, Batista Arantes LMR, Galbiatti-Dias ALS, Maria Goloni Bertollo E., Free PMC Article | 09/4/2021 |
| Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells. | Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells.
Fawal MA, Jungas T, Davy A. | 08/7/2021 |
| Dihydrofolate Reductase (DHFR) del19bp Polymorphism and Down Syndrome Offspring. | Dihydrofolate Reductase (DHFR) del19bp Polymorphism and Down Syndrome Offspring.
Costa-Lima MA, Barboza HN, Aprigio J, de Melo Moura C, Quirico-Santos TF, Ribeiro MG, Amorim MR. | 06/12/2021 |
| Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia. | Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.
Tulstrup M, Moriyama T, Jiang C, Grosjean M, Nersting J, Abrahamsson J, Grell K, Hjalgrim LL, Jónsson ÓG, Kanerva J, Lund B, Nielsen SN, Nielsen RL, Overgaard U, Quist-Paulsen P, Pruunsild K, Vaitkeviciene G, Wolthers BO, Zhang H, Gupta R, Yang JJ, Schmiegelow K., Free PMC Article | 03/27/2021 |
| Casein kinase 2 alpha strongly interacts with and phosphorylates dihydrofolate reductase. | Human dihydrofolate reductase is a substrate of protein kinase CK2α.
Skierka K, Wilamowski P, Wielechowska M, Cysewski D, Senkara E, Wińska P, Bretner M, Cieśla J. | 05/2/2020 |
| Variants in TYMS, SLC19A1 and DHFR genes are potential biomarkers of myelotoxicity and could be used for 6-MP therapy individualization in maintenance phase of childhood ALL treatment, alongside with well-established TPMT variants. | Influence of variants in folate metabolism genes on 6-mercaptopurine induced toxicity during treatment for childhood acute lymphocytic leukemia.
Milosevic G, Kotur N, Lazic J, Krstovski N, Stankovic B, Zukic B, Janic D, Jurisic V, Pavlovic S, Dokmanovic L. | 05/2/2020 |
| These results indicated that hDHFR is not the only target of Pyr. We further found that thymidine phosphorylase (TP), an enzyme that is closely associated with the EMT of cancer cells, is also a target protein of Pyr. The data retrieved from the Cancer Genome Atlas (TCGA) database revealed that TP overexpression is associated with poor prognosis of patients with lung cancer | Antimalarial Drug Pyrimethamine Plays a Dual Role in Antitumor Proliferation and Metastasis through Targeting DHFR and TP.
Liu H, Qin Y, Zhai D, Zhang Q, Gu J, Tang Y, Yang J, Li K, Yang L, Chen S, Zhong W, Meng J, Liu Y, Sun T, Yang C. | 03/14/2020 |
| Results showed that the dominant alleles in three genes (DHFR, MTHFR, TYMS) were associated with hematologic toxicity, but none of them was associated with methotrexate level, hepatotoxicity or renal function | Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia.
Yousef AM, Farhad R, Alshamaseen D, Alsheikh A, Zawiah M, Kadi T. | 01/25/2020 |
| Four single nucleotide polymorphisms (FOLH1: rs202676, DHFR: rs70991108, MTHFR: rs1801133 and rs1801131) associations with neural tube defects (NTDs) were evaluated.Genotype and allele frequency revealed that, rs1801133 (p.Ala222Val) was significantly associated with NTDs risk (p value = 0.028), whereas rs202676 (p.Tyr60His) showed protective role (p value = 0.0066). No significance was seen for rs70991108 or rs1801131. | Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India.
Paul S, Sadhukhan S, Munian D, Bankura B, Das M. | 06/22/2019 |
| The -829C-T polymorphism of DHFR gene was not associated with response to Methotrexate by Rheumatoid Arthritis patients, and no variations were found in the miRNA-24 sequence that might modify the response to treatment or DHFR enzyme levels in a Mexican population with Rheumatoid Arthritis. | miRNA-24 Gene Sequence, DHFR -829C-T Genotypes, and Methotrexate Response in Mexican Patients with Rheumatoid Arthritis.
Hernández-Preciado MR, Morán-Moguel MC, Dávalos-Rodríguez IP, Enríquez-Barajas CM, Valdovinos-Maravilla JP, Díaz-Pérez AL, Silva-Castro DE, González-López L, Gámez-Nava JI, Aceves-Aceves MA, Salazar-Páramo M., Free PMC Article | 05/25/2019 |
| influence of maternal transmission of DHFR 19 bp deletion in the development of anencephaly in the foetus | Maternal association and influence of DHFR 19 bp deletion variant predisposes foetus to anencephaly susceptibility: a family-based triad study.
Prasoona KR, Sunitha T, Srinadh B, Muni Kumari T, Jyothy A. | 03/9/2019 |
| in a study investigating whether rs1650697 polymorphism in DHFR gene may impact methotrexate efficacy and/or adverse drug effects, the results showed that the presence of T allele might be protective against methotrexate hepatotoxicity measured by transaminase levels | Association of C35T polymorphism in dihydrofolate reductase gene with toxicity of methotrexate in rheumatoid arthritis patients.
Vejnović D, Milić V, Popović B, Damnjanović T, Maksimović N, Bunjevački V, Krajinović M, Novaković I, Damjanov N, Jekić B. | 03/2/2019 |
| In ALL and NHL patients treated with methotrexate, treatment toxicities and outcome were evaluated. Multivariate analysis showed that DHFR-1610G/T (OR=0.107, p=0.018) and MTHFR677T alleles (OR=0.12, p=0.026) had a strong protective effect against hematologic toxicity, while DHFR-1610CC genotype increased this toxicity (OR=9, p=0.045). | Methotrexate pharmacogenetics in Uruguayan adults with hematological malignant diseases.
Giletti A, Vital M, Lorenzo M, Cardozo P, Borelli G, Gabus R, Martínez L, Díaz L, Assar R, Rodriguez MN, Esperón P. | 07/28/2018 |
| Dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells. | Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.
Antosiewicz A, Jarmuła A, Przybylska D, Mosieniak G, Szczepanowska J, Kowalkowska A, Rode W, Cieśla J. | 02/17/2018 |
| Single nucleotide polymorphism in DHFR gene is associated with Systemic lupus erythematosus. | Polymorphisms of the folate metabolizing enzymes: Association with SLE susceptibility and in silico analysis.
Salimi S, Keshavarzi F, Mohammadpour-Gharehbagh A, Moodi M, Mousavi M, Karimian M, Sandoughi M. | 12/16/2017 |
| study concludes polymorphism 63/91 in DHFR gene promoter can modulate the onset of methotrexate-related adverse effects in rheumatoid arthritis patients | Association of 63/91 length polymorphism in the DHFR gene major promoter with toxicity of methotrexate in patients with rheumatoid arthritis.
Jekic B, Vejnovic D, Milic V, Maksimovic N, Damnjanovic T, Bunjevacki V, Novakovic I, Lukovic L, Damjanov N, Krajinovic M. | 11/11/2017 |
| our findings suggest that the identification of DHFR polymorphisms in the promoter region of the gene may be helpful in tailoring MTX doses for ALL pediatric patients on maintenance therapy. | Dihydrofolate Reductase Genetic Polymorphisms Affect Methotrexate Dose Requirements in Pediatric Patients With Acute Lymphoblastic Leukemia on Maintenance Therapy.
Gervasini G, de Murillo SG, Jiménez M, de la Maya MD, Vagace JM. | 11/4/2017 |
| The abundance of dihydrofolate reductase was statistically significantly increased in rheumatoid arthritis (RA)-patient biopsies compared with controls and correlated with the administered dosage of methotrexate (MTX), the most frequently prescribed immunosuppressive drug for RA. | Proteome Analysis of Rheumatoid Arthritis Gut Mucosa.
Bennike TB, Ellingsen T, Glerup H, Bonderup OK, Carlsen TG, Meyer MK, Bøgsted M, Christiansen G, Birkelund S, Andersen V, Stensballe A. | 10/21/2017 |
| The present study demonstrated that ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'-UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate in MCF-7 cells. | A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer.
Nakano M, Fukami T, Gotoh S, Nakajima M., Free PMC Article | 06/24/2017 |
| In conclusion, the finding suggests that folate nutrition and 19bp del-DHFR [Dihydrofolate reductase] variation may interact to modify adenomatous polyp [colorectal cancer] risk. | Gene-Nutrient Interaction between Folate and Dihydrofolate Reductase in Risk for Adenomatous Polyp Occurrence: A Preliminary Report.
Choi JH, Yates Z, Martin C, Boyd L, Ng X, Skinner V, Wai R, Veysey M, Lucock M. | 11/5/2016 |
| the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum | Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Shimamoto Y, Nukatsuka M, Takechi T, Fukushima M., Free PMC Article | 10/29/2016 |