| Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control. | Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control.
Shi Q, Malik H, Crawford RM, Streeter J, Wang J, Huo R, Shih JC, Chen B, Hall D, Abel ED, Song LS, Anderson EJ., Free PMC Article | 05/30/2024 |
| Upregulation of MAOA in the hippocampus results in delayed depressive-like behaviors in burn mice. | Upregulation of MAOA in the hippocampus results in delayed depressive-like behaviors in burn mice.
Wang Z, Chen L, Rong X, Wang X. | 04/18/2024 |
| Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression. | Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression.
Lapierre JA, Geary LA, Jang JK, Epstein AL, Hong F, Shih JC. | 11/12/2022 |
| Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase. | Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
Bajaj J, Dwivedi J, Sahu R, Dave V, Verma K, Joshi S, Sati B, Sharma S, Seidel V, Mishra AP. | 03/12/2022 |
| Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus. | Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus.
Moriya S, Takahashi H, Masukawa D, Yamada M, Ishigooka J, Nishimura K. | 06/19/2021 |
| MAOA expression and enzyme activity was reduced in hypothalamus and increased in prefrontal cortex of prepubertally stressed hyper-aggressive male mice. Hypomethylation in prefrontal cortex and hypermethylation in hypothalamus of MAOA promoter negatively correlated with the expression pattern. Sirt1 binding to the MAOA promoter was increased in prefrontal cortex and reduced in hypothalamus. In females, MAO was unchanged. | Brain region specific methylation and Sirt1 binding changes in MAOA promoter is associated with sexual dimorphism in early life stress induced aggressive behavior.
Konar A, Rastogi M, Bhambri A. | 05/16/2020 |
| MAO inhibition prevented both mast cell degranulation and altered collagen deposition, thereby normalizing diastolic function. These results elucidate the mechanisms underlying MAO-induced damage in diabetic cardiomyopathy and provide novel evidence for the role of MAOs in inflammation and inter-organelle communication. | Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.
Deshwal S, Forkink M, Hu CH, Buonincontri G, Antonucci S, Di Sante M, Murphy MP, Paolocci N, Mochly-Rosen D, Krieg T, Di Lisa F, Kaludercic N., Free PMC Article | 09/14/2019 |
| Reactive oxygen species produced by MAO-A lead to the accumulation of p53 in the cytosol where it inhibits parkin, an important regulator of mitophagy, resulting in mitochondrial dysfunction. | Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.
Manzella N, Santin Y, Maggiorani D, Martini H, Douin-Echinard V, Passos JF, Lezoualc'h F, Binda C, Parini A, Mialet-Perez J., Free PMC Article | 09/14/2019 |
| mice lacking both MAO isoforms, MAOA and MAOB, exhibit smaller prostate mass and develop epithelial atrophy in the ventral and dorsolateral prostates. | Monoamine Oxidase Deficiency Causes Prostate Atrophy and Reduces Prostate Progenitor Cell Activity.
Yin L, Li J, Liao CP, Jason Wu B. | 08/17/2019 |
| Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate | Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate.
Liao CP, Lin TP, Li PC, Geary LA, Chen K, Vaikari VP, Wu JB, Lin CH, Gross ME, Shih JC., Free PMC Article | 02/23/2019 |
| Study provides experimental evidence showing that sleep deprivation induces an increase in monoamine oxidase A levels in certain brain regions, such as the amygdala and hippocampus of mice that might mediate depressive-like behaviors. | Paradoxical sleep deprivation modulates depressive-like behaviors by regulating the MAOA levels in the amygdala and hippocampus.
Wang Z, Chen L, Zhang L, Wang X. | 02/24/2018 |
| This study unravels a new link between MAO-dependent H2O2 production and lysosomal dysfunction. Altogether, our findings demonstrate that the MAO-A/H2O2 axis has a negative impact on the elimination and recycling of mitochondria through the autophagy-lysosome pathway, which participates in cardiomyocyte death and heart failure | Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure.
Santin Y, Sicard P, Vigneron F, Guilbeau-Frugier C, Dutaur M, Lairez O, Couderc B, Manni D, Korolchuk VI, Lezoualc'h F, Parini A, Mialet-Perez J. | 07/15/2017 |
| Results demonstrate that C17H11IOSe, a selective inhibitor of cortical MAO-A, elicited an antidepressant-like action in mice by interacting with the serotonergic system | Selective inhibition of MAO-A activity results in an antidepressant-like action of 2-benzoyl 4-iodoselenophene in mice.
Velasquez D, Quines C, Pistóia R, Zeni G, Nogueira CW. | 06/24/2017 |
| data lead us to conclude that elevation of AP-1 or NF-kB indirectly decreases MAO-A protein levels which, in turn, diminishes MAO-A ability in the VTA of the mesolimbic dopaminergic pathway | Amphetamine manipulates monoamine oxidase-A level and behavior using theranostic aptamers of transcription factors AP-1/NF-kB.
Liu CH, Ren J, Liu PK., Free PMC Article | 10/22/2016 |
| Huntington disease neural cells exhibit increased Monoamine oxidase-A and Monoamine oxidases-B expression and activity | Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
Ooi J, Hayden MR, Pouladi MA., Free PMC Article | 09/3/2016 |
| acute stress induces anxiety-like responses by affecting rapid dendritic remodeling in the pyramidal cells of orbitofrontal cortex and basolateral amygdala; furthermore, our data show that MAO-A and monoamine metabolism are required for these phenomena. | Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress.
Godar SC, Bortolato M, Richards SE, Li FG, Chen K, Wellman CL, Shih JC., Free PMC Article | 05/28/2016 |
| These findings demonstrate that regulation of monoamine levels by Mao activity in beta cells is pivotal for physiological insulin secretion and that loss of MaoB expression may contribute to the beta cell dysfunction in type 2 diabetes. | Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.
Ganic E, Johansson JK, Bennet H, Fex M, Artner I. | 04/23/2016 |
| Results suggest a role for KLF11 in upregulating MAO-A in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses | Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders.
Harris S, Johnson S, Duncan JW, Udemgba C, Meyer JH, Albert PR, Lomberk G, Urrutia R, Ou XM, Stockmeier CA, Wang JM., Free PMC Article | 04/2/2016 |
| The results of this study suggest that heightened dACC and amygdala activation and their connectivity are neuroaffective mechanisms underlying anger control in participants with the low-functioning allele of the MAOA gene. | A functional polymorphism of the MAOA gene is associated with neural responses to induced anger control.
Denson TF, Dobson-Stone C, Ronay R, von Hippel W, Schira MM. | 01/10/2015 |
| These results suggest that early developmental enhancements in 5-HT levels have long-term effects on the modulation of behavioral flexibility associated with MAO-A deficiency. | Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice.
Bortolato M, Godar SC, Tambaro S, Li FG, Devoto P, Coba MP, Chen K, Shih JC., Free PMC Article | 08/23/2014 |
| Under conditions of chronic hemodynamic stress, enhanced MAO-B activity is a major determinant of cardiac structural and functional disarrangement. | Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.
Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N., Free PMC Article | 08/16/2014 |
| Knockdown of MAO-A expression in embryos induces high serotonin levels and abnormal brain development, which can be rescued by inactivation of serotonin receptor-6. | Serotonin receptor 6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos.
Wang CC, Man GC, Chu CY, Borchert A, Ugun-Klusek A, Billett EE, Kühn H, Ufer C., Free PMC Article | 05/31/2014 |
| Both monoamine oxidase A (and B) knockout mice displayed neuropathological alterations typical of autism-spectrum disorders. | Monoamine oxidase A and A/B knockout mice display autistic-like features.
Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL, Bini V, Chen K, Wellman CL, Lin RC, Shih JC., Free PMC Article | 12/28/2013 |
| chronic elevations of monoamines, because of the absence of MAO A and MAO B, cause functional alterations that are accompanied with changes in the cellular mechanisms underlying learning and memory. | Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.
Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, Shih JC., Free PMC Article | 11/30/2013 |
| MAO-A is expressed in the mouse aorta, induced by in vivo lipopolysaccharide and angiotensin II treatment and contribute via the generation of H(2)O(2) to endothelial dysfunction in vascular disease models. | Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta.
Sturza A, Leisegang MS, Babelova A, Schröder K, Benkhoff S, Loot AE, Fleming I, Schulz R, Muntean DM, Brandes RP. | 09/7/2013 |