| TRPM8 affects relative "cooling and heating" of subcellular organelles in microglia in a context-dependent manner. | TRPM8 affects relative "cooling and heating" of subcellular organelles in microglia in a context-dependent manner.
Shikha D, Chang YT, Goswami C. | 08/20/2024 |
| Separation of Oral Cooling and Warming Requires TRPM8. | Separation of Oral Cooling and Warming Requires TRPM8.
Li J, Zumpano KT, Lemon CH., Free PMC Article | 03/21/2024 |
| [Effect of TRPM8 on pain symptom and neuronal proliferation in mice with interstitial cystitis/bladder pain syndrome]. | [Effect of TRPM8 on pain symptom and neuronal proliferation in mice with interstitial cystitis/bladder pain syndrome].
Fan BH, Zhang P. | 02/29/2024 |
| Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea. | Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.
Feng J, Yang L, Ran L, Qi X, Wang X, Zhang Y, Zou Z, Liu T, Wang X, Yu Y, Sun X, Zhou Q., Free PMC Article | 12/22/2023 |
| Modulation of TRPM8 alters the phagocytic activity of microglia and induces changes in sub-cellular organelle functions. | Modulation of TRPM8 alters the phagocytic activity of microglia and induces changes in sub-cellular organelle functions.
Shikha D, Mahish C, Sing R, Chattopadhyay S, Goswami C. | 11/13/2023 |
| Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus. | Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus.
Tsuneoka Y, Nishikawa T, Furube E, Okamoto K, Yoshimura R, Funato H, Miyata S. | 09/26/2023 |
| Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice. | Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.
Liskiewicz D, Zhang Q, Barthem CS, Jastroch M, Liskiewicz A, Khajavi N, Grandl G, Coupland C, Kleinert M, Garcia-Caceres C, Novikoff A, Maity G, Boehm U, Tschöp MH, Müller TD., Free PMC Article | 05/12/2023 |
| Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRalpha3. | Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.
Yang C, Yamaki S, Jung T, Kim B, Huyhn R, McKemy DD., Free PMC Article | 04/19/2023 |
| The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature. | The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature.
Reimúndez A, Fernández-Peña C, Ordás P, Hernández-Ortego P, Gallego R, Morenilla-Palao C, Navarro J, Martín-Cora F, Pardo-Vázquez JL, Schwarz LA, Arce V, Viana F, Señarís R. | 03/14/2023 |
| Effect of TRPM8 Functional Loss on Corneal Epithelial Wound Healing in Mice. | Effect of TRPM8 Functional Loss on Corneal Epithelial Wound Healing in Mice.
Ran L, Feng J, Qi X, Liu T, Qi B, Jiang K, Zhang Z, Yu Y, Zhou Q, Xie L., Free PMC Article | 02/4/2023 |
| TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1alpha. | TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α.
Lei X, Liu Q, Qin W, Tong Q, Li Z, Xu W, Liu G, Fu J, Zhang J, Kuang T, Shao Y, Liu C, Fang Y, Cao Z, Yan L, Liu Z, Liu S, Yamamoto H, Mori M, Liang XM, Xu X., Free PMC Article | 12/24/2022 |
| Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice. | Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice.
Wei C, Kim B, McKemy DD., Free PMC Article | 11/26/2022 |
| TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine. | TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine.
Alarcón-Alarcón D, Cabañero D, de Andrés-López J, Nikolaeva-Koleva M, Giorgi S, Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A., Free PMC Article | 10/29/2022 |
| Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol. | Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol.
Huang SS, Su HH, Chien SY, Chung HY, Luo ST, Chu YT, Wang YH, MacDonald IJ, Lee HH, Chen YH., Free PMC Article | 08/6/2022 |
| Structures of a mammalian TRPM8 in closed state. | Structures of a mammalian TRPM8 in closed state.
Zhao C, Xie Y, Xu L, Ye F, Xu X, Yang W, Yang F, Guo J., Free PMC Article | 06/11/2022 |
| Role of TRPM8 in cold avoidance behaviors and brain activation during innocuous and nocuous cold stimuli. | Role of TRPM8 in cold avoidance behaviors and brain activation during innocuous and nocuous cold stimuli.
Kasuga R, Shiraki C, Horikawa R, Yoshimura R, Kurganov E, Miyata S. | 05/7/2022 |
| Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies. | Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies.
Genovesi S, Moro R, Vignoli B, De Felice D, Canossa M, Montironi R, Carbone FG, Barbareschi M, Lunardi A, Alaimo A., Free PMC Article | 04/9/2022 |
| In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening. | In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening.
Iraci N, Ostacolo C, Medina-Peris A, Ciaglia T, Novoselov AM, Altieri A, Cabañero D, Fernandez-Carvajal A, Campiglia P, Gomez-Monterrey I, Bertamino A, Kurkin AV., Free PMC Article | 03/12/2022 |
| Rational Design of a Modality-Specific Inhibitor of TRPM8 Channel against Oxaliplatin-Induced Cold Allodynia. | Rational Design of a Modality-Specific Inhibitor of TRPM8 Channel against Oxaliplatin-Induced Cold Allodynia.
Aierken A, Xie YK, Dong W, Apaer A, Lin JJ, Zhao Z, Yang S, Xu ZZ, Yang F., Free PMC Article | 03/12/2022 |
| Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality. | Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality.
McKie GL, Medak KD, Shamshoum H, Wright DC. | 03/5/2022 |
| Protective Effect of TRPM8 against Indomethacin-Induced Small Intestinal Injury via the Release of Calcitonin Gene-Related Peptide in Mice. | Protective Effect of TRPM8 against Indomethacin-Induced Small Intestinal Injury via the Release of Calcitonin Gene-Related Peptide in Mice.
Fouad A, Matsumoto K, Amagase K, Yasuda H, Tominaga M, Kato S. | 01/1/2022 |
| Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits. | Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits.
Ordás P, Hernández-Ortego P, Vara H, Fernández-Peña C, Reimúndez A, Morenilla-Palao C, Guadaño-Ferraz A, Gomis A, Hoon M, Viana F, Señarís R. | 12/18/2021 |
| Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function. | Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function.
Rivera B, Moreno C, Lavanderos B, Hwang JY, Fernández-Trillo J, Park KS, Orio P, Viana F, Madrid R, Pertusa M., Free PMC Article | 11/27/2021 |
| TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss. | TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss.
Lelis Carvalho A, Treyball A, Brooks DJ, Costa S, Neilson RJ, Reagan MR, Bouxsein ML, Motyl KJ., Free PMC Article | 10/30/2021 |
| TRPM8 channel augments T-cell activation and proliferation. | TRPM8 channel augments T-cell activation and proliferation.
Acharya TK, Tiwari A, Majhi RK, Goswami C. | 08/14/2021 |