| A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury. | A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury.
Yang C, Xu H, Yang D, Xie Y, Xiong M, Fan Y, Liu X, Zhang Y, Xiao Y, Chen Y, Zhou Y, Song L, Wang C, Peng A, Petersen RB, Chen H, Huang K, Zheng L., Free PMC Article | 07/24/2023 |
| KIM-1 augments hypoxia-induced tubulointerstitial inflammation through uptake of small extracellular vesicles by tubular epithelial cells. | KIM-1 augments hypoxia-induced tubulointerstitial inflammation through uptake of small extracellular vesicles by tubular epithelial cells.
Chen J, Tang TT, Cao JY, Li ZL, Zhong X, Wen Y, Shen AR, Liu BC, Lv LL., Free PMC Article | 05/10/2023 |
| T-Cell Immunoglobulin and Mucin Domain 1 (TIM-1) Is a Functional Entry Factor for Tick-Borne Encephalitis Virus. | T-Cell Immunoglobulin and Mucin Domain 1 (TIM-1) Is a Functional Entry Factor for Tick-Borne Encephalitis Virus.
Zhang X, Liang C, Wang H, Guo Z, Rong H, Pan J, Li W, Pei R, Chen X, Zhang Z, Zhang XE, Cui Z., Free PMC Article | 03/2/2023 |
| Tim-1 mucin domain-mutant mice display exacerbated atherosclerosis. | Tim-1 mucin domain-mutant mice display exacerbated atherosclerosis.
Douna H, Smit V, van Puijvelde GHM, Kiss MG, Binder CJ, Bot L, Kuchroo VK, Lichtman AH, Kuiper J, Foks AC. | 07/2/2022 |
| Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study. | Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study.
McCoy IE, Hsu JY, Bonventre JV, Parikh CR, Go AS, Liu KD, Ricardo AC, Srivastava A, Cohen DL, He J, Chen J, Rao PS, Hsu CY, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators., Free PMC Article | 06/11/2022 |
| Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma. | Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma.
Lee JC, Yotis DM, Lee JY, Sarabusky MA, Shrum B, Champagne A, Ismail OZ, Tutunea-Fatan E, Leong HS, Gunaratnam L., Free PMC Article | 11/22/2021 |
| Rutin coated gold nanoparticles prevent rhabdomyolysis-induced kidney injury via down-regulation of NF-kB, iNOS, IL-6 and up-regulation of HO-1 and Kim-1 genes in mice. | Rutin coated gold nanoparticles prevent rhabdomyolysis-induced kidney injury via down-regulation of NF-kB, iNOS, IL-6 and up-regulation of HO-1 and Kim-1 genes in mice.
Saifulah N, Siddiqui RA, Ismail MO, Memon Z, Aslam Z, Shah MR. | 10/23/2021 |
| KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury. | KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury.
Al-Bataineh MM, Kinlough CL, Mi Z, Jackson EK, Mutchler SM, Emlet DR, Kellum JA, Hughey RP., Free PMC Article | 09/25/2021 |
| Mapping and functional characterization of murine kidney injury molecule-1 proteolytic cleavage site. | Mapping and functional characterization of murine kidney injury molecule-1 proteolytic cleavage site.
Sriranganathan S, Tutunea-Fatan E, Abbasi A, Gunaratnam L. | 07/17/2021 |
| These studies provide evidence that at late times during Ebola virus glycoprotein/recombinant vesiculovirus infection, TIM-1 increased virus load and associated mortality, consistent with an important role of this receptor in virus entry. | TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis.
Brunton B, Rogers K, Phillips EK, Brouillette RB, Bouls R, Butler NS, Maury W., Free PMC Article | 11/30/2019 |
| Our findings suggest a role for UMOD-dependent inhibition of KIM-1 expression and its apoptotic cell scavenging responses during chronic obstruction-associated tubular injury | Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.
Maydan O, McDade PG, Liu Y, Wu XR, Matsell DG, Eddy AA., Free PMC Article | 03/23/2019 |
| findings show that TIM1 is not required for hepatitis A virus (HAV) replication and pathogenesis in permissive strains of mice, although it may facilitate early stages of infection by binding phosphatidylserine on the quasi-enveloped HAV surface | TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions.
Das A, Hirai-Yuki A, González-López O, Rhein B, Moller-Tank S, Brouillette R, Hensley L, Misumi I, Lovell W, Cullen JM, Whitmire JK, Maury W, Lemon SM., Free PMC Article | 06/30/2018 |
| the interaction of TIM4TIM1 was found to promote Th2cell proliferation through enhancing SIRT1 expression in mice with nasal allergic rhinitis. | TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression.
Hu T, Fan X, Ma L, Liu J, Chang Y, Yang P, Qiu S, Chen T, Yang L, Liu Z., Free PMC Article | 06/2/2018 |
| findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of Ebola virus disease | Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.
Younan P, Iampietro M, Nishida A, Ramanathan P, Santos RI, Dutta M, Lubaki NM, Koup RA, Katze MG, Bukreyev A., Free PMC Article | 05/19/2018 |
| Cisplatin enhances kidney injury molecule-1 (Kim-1) gene expression in kidney S3 cells. | A kidney injury molecule-1 (Kim-1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells.
Kokura K, Kuromi Y, Endo T, Anzai N, Kazuki Y, Oshimura M, Ohbayashi T., Free PMC Article | 02/3/2018 |
| By preventing ERK1/2 phosphorylation following renal injury, STAT3 phosphorylation is decreased, leading to less phosphorylated STAT3 within the nucleus, and subsequently less KIM-1 mRNA increases post injury | Extracellular Signal-Regulated Kinase 1/2 Regulates Mouse Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury.
Collier JB, Schnellmann RG., Free PMC Article | 12/2/2017 |
| Study used a previously described highly mobile membrane mimetic membrane in combination with a conventional lipid bilayer model to generate a membrane-bound configuration of Tim1 in silico, identified two possible states for a membrane-bound form of Tim1. | Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1.
Tietjen GT, Baylon JL, Kerr D, Gong Z, Henderson JM, Heffern CTR, Meron M, Lin B, Schlossman ML, Adams EJ, Tajkhorshid E, Lee KYC., Free PMC Article | 12/2/2017 |
| Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 to mediate this process. | G protein α(12) (Gα(12)) is a negative regulator of kidney injury molecule-1-mediated efferocytosis.
Ismail OZ, Zhang X, Bonventre JV, Gunaratnam L., Free PMC Article | 07/8/2017 |
| Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase of kidney injury and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. These markers could detect higher risk of progression to CKD. | Increase in urinary markers during the acute phase reflects the degree of chronic tubulointerstitial injury after ischemia-reperfusion renal injury.
Hisamichi M, Kamijo-Ikemori A, Sugaya T, Ichikawa D, Hoshino S, Hirata K, Kimura K, Shibagaki Y. | 02/4/2017 |
| Blockade of Tim-1 changes Th1/Th2 balance and reduces circulating regulatory T cells to enhance atherosclerosis in LDL receptor knockout mice. | Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.
Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum JL, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH., Free PMC Article | 07/16/2016 |
| Our results suggest that KIM-1 is an endogenous protective mechanism against renal ischemia-reperfusion injury | Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury.
Ismail OZ, Zhang X, Wei J, Haig A, Denker BM, Suri RS, Sener A, Gunaratnam L., Free PMC Article | 01/23/2016 |
| data suggest that TIM-1 signaling plays a direct role in Breg maintenance and induction both under physiological conditions (in response to ACs) and in response to therapy through TIM-1 ligation | TIM-1 signaling is required for maintenance and induction of regulatory B cells.
Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM., Free PMC Article | 12/19/2015 |
| Deletion of the mucin domain impaired KIM-1-mediated phagocytic function, resulting in increased proinflammatory cytokine production, decreased antiinflammatory growth factor secretion by proximal epithelial cells, and an increase in tissue macrophages. | KIM-1-mediated phagocytosis reduces acute injury to the kidney.
Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV., Free PMC Article | 07/4/2015 |
| Tim-1 is critical for maintaining self-tolerance by regulating IL-10 production in Bregs | Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.
Xiao S, Brooks CR, Sobel RA, Kuchroo VK., Free PMC Article | 04/25/2015 |
| blood biomarker that specifically reflects acute and chronic kidney injury | Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes.
Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C, Ravisankar A, Ito K, Sharma S, Ramadesikan S, Lee M, Briskin R, De Jager PL, Ngo TT, Radlinski M, Dear JW, Park KB, Betensky R, Krolewski AS, Bonventre JV., Free PMC Article | 12/20/2014 |