| Acute inhibition of IRAP aminopeptidase activity does not affect glucose homeostasis. | Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats.
Albiston AL, Cacador M, Sinnayah P, Burns P, Chai SY. | 02/17/2018 |
| Ang IV protects myocardial injury against reperfusion by inhibiting inflammation and apoptosis via AT4R and PI3K-Akt-mTOR signaling pathway in anesthetized rats. | Angiotensin IV protects cardiac reperfusion injury by inhibiting apoptosis and inflammation via AT4R in rats.
Park BM, Cha SA, Lee SH, Kim SH. | 03/18/2017 |
| IRAP is involved in vesicular trafficking and shares common regional distribution with the sst2A receptor in the hippocampus. | Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures.
De Bundel D, Fafouri A, Csaba Z, Loyens E, Lebon S, El Ghouzzi V, Peineau S, Vodjdani G, Kiagiadaki F, Aourz N, Coppens J, Walrave L, Portelli J, Vanderheyden P, Chai SY, Thermos K, Bernard V, Collingridge G, Auvin S, Gressens P, Smolders I, Dournaud P., Free PMC Article | 11/28/2015 |
| Sol and MB CysAP activities, acting separately or in concert and mainly in renal medulla, regulate the function of their susceptible endogenous substrates, and may participate meaningfully in the control of blood pressure and fluid balance. | Tissue distribution of CysAP activity and its relationship to blood pressure and water balance.
Prieto I, Villarejo AB, Segarra AB, Wangensteen R, Banegas I, de Gasparo M, Vanderheyden P, Zorad S, Vives F, Ramírez-Sánchez M. | 09/26/2015 |
| Increased calcium influx through postsynaptic calcium channels contribute to Norleucine1-angiotensin IV receptor-induced enhancement of long-term potentiation. | AT4 receptor activation increases intracellular calcium influx and induces a non-N-methyl-D-aspartate dependent form of long-term potentiation.
Davis CJ, Kramár EA, De A, Meighan PC, Simasko SM, Wright JW, Harding JW. | 10/5/2011 |
| found a decrease of hypothalamic IRAP activity and an increase in circulating levels of oxytocin | Hypothalamus-pituitary-thyroid axis disruption in rats with breast cancer is related to an altered endogenous oxytocin/insulin-regulated aminopeptidase (IRAP) system.
Carrera-González MP, Ramírez-Expósito MJ, de Saavedra JM, Sánchez-Agesta R, Mayas MD, Martínez-Martos JM. | 07/16/2011 |
| The present study clearly demonstrated that the activities of AlaAP and CysAP in the hippocampus were associated with lateralization in normal rats. | Correlations between angiotensinase activity asymmetries in the brain and paw preference in rats.
Wu HM, Wang C, Wang XL, Wang L, Chang CW, Wang P, Gao GD. | 08/9/2010 |
| results show that acute immobilization stress affects differentially enkephalinase and oxytocinase activities depending on the fraction and brain region analyzed | Stress influences brain enkephalinase, oxytocinase and angiotensinase activities: a new hypothesis.
Hernández J, Segarra AB, Ramírez M, Banegas I, de Gasparo M, Alba F, Vives F, Durán R, Prieto I. | 01/21/2010 |
| Acyl-coa dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptides (VP165) in a manner dependent on its dileucine motif | Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif.
Katagiri H, Asano T, Yamada T, Aoyama T, Fukushima Y, Kikuchi M, Kodama T, Oka Y. | 01/21/2010 |
| IRAP vesicles represent a second IgE-sensitive exocytotic compartment in mast cells | Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells.
Liao H, Keller SR, Castle JD. | 01/21/2010 |
| Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase (vp165) in vitro at Ser-80 and Ser-91. | Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase in vitro at Ser-80 and Ser-91.
Ryu J, Hah JS, Park JS, Lee W, Rampal AL, Jung CY. | 01/21/2010 |
| We therefore hypothesize that the effect of angiotensin IV on dopamine release in the striatum is mediated via activation of IRAP and/or AP-N, possibly acting as receptors for angiotensin IV. | Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.
Stragier B, Demaegdt H, De Bundel D, Smolders I, Sarre S, Vauquelin G, Ebinger G, Michotte Y, Vanderheyden P. | 01/21/2010 |
| Aminopeptidase was found expressed in olfactory regions, in septal and hypothalamic nuclei, throughout the hippocampal formation and cerebral cortex, and in motor and motor associated nuclei. IRAP was expressed exclusively in neurons in these regions. | Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system.
Fernando RN, Larm J, Albiston AL, Chai SY. | 01/21/2010 |
| These results suggest that arginine-vasopressin (AVP) induces the translocation of placental leucine aminopeptidase (P-LAP) via V2 vasopressin receptors, and that P-LAP plays a role in the regulation of AVP levels in the renal collecting duct [P-LAP]. | Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells.
Masuda S, Hattori A, Matsumoto H, Miyazawa S, Natori Y, Mizutani S, Tsujimoto M. | 01/21/2010 |