| Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model. | Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
Yip JLK, Xavier S, Balasuriya GK, Hill-Yardin EL, Spencer SJ., Free PMC Article | 11/1/2023 |
| Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-kappaB Activity. | Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-κB Activity.
Faridvand Y, Nemati M, Zamani-Gharehchamani E, Nejabati HR, Zamani ARN, Nozari S, Safaie N, Nouri M, Jodati A. | 07/23/2022 |
| FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats. | FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats.
Zhou Y, Zhang L, Hao Y, Yang L, Fan S, Xiao Z., Free PMC Article | 04/16/2022 |
| Monocyte perturbation modulates the ovarian response to an immune challenge. | Monocyte perturbation modulates the ovarian response to an immune challenge.
Younesi S, Spencer SJ, Sominsky L. | 01/22/2022 |
| MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling. | MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling.
Mao M, Xu Y, Zhang XY, Yang L, An XB, Qu Y, Chai YN, Wang YR, Li TT, Ai J., Free PMC Article | 07/17/2021 |
| CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage. | CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage.
Chen X, Jiang M, Li H, Wang Y, Shen H, Li X, Zhang Y, Wu J, Yu Z, Chen G., Free PMC Article | 05/29/2021 |
| Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems. | Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
Chamera K, Szuster-Głuszczak M, Trojan E, Basta-Kaim A., Free PMC Article | 03/6/2021 |
| CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation. | CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation.
Noh C, Shin HJ, Lee S, Kim SI, Kim YH, Lee WH, Kim DW, Lee SY, Ko YK., Free PMC Article | 02/13/2021 |
| A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis. | A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis.
Chen G, Zhou Z, Sha W, Wang L, Yan F, Yang X, Qin X, Wu M, Li D, Tian S, Chen G., Free PMC Article | 02/6/2021 |
| Notch activation enhances microglial CX3CR1/P38 MAPK pathway in rats model of vincristine-induced peripheral neuropathy. | Notch activation enhances microglial CX3CR1/P38 MAPK pathway in rats model of vincristine-induced peripheral neuropathy.
Qin B, Li Y, Liu X, Gong D, Zheng W. | 01/9/2021 |
| CX3CL1/CX3CR1-signalling in the CD9/S100beta/SOX2-positive adult pituitary stem/progenitor cells modulates differentiation into endothelial cells. | CX3CL1/CX3CR1-signalling in the CD9/S100β/SOX2-positive adult pituitary stem/progenitor cells modulates differentiation into endothelial cells.
Horiguchi K, Fujiwara K, Yoshida S, Tsukada T, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y. | 12/19/2020 |
| gene expression of the metabotropic purinergic receptor P2Y12 and the fractalkine receptor CX3CR1 was downregulated in the Medulla oblongata of Spontaneously Hypertensive Rats compared to Wistar kyoto rats (by 37.3% and 30.9% respectively). | Microglia in the RVLM of SHR have reduced P2Y12R and CX3CR1 expression, shorter processes, and lower cell density.
Cohen EM, Mohammed S, Kavurma M, Nedoboy PE, Cartland S, Farnham MMJ, Pilowsky PM. | 03/14/2020 |
| changes in PSD-95 expression on individual newly formed hippocampal neurons can be altered by immune modulation. | Decreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain.
Ali I, Avdic U, Chugh D, Ekdahl CT., Free PMC Article | 09/14/2019 |
| The present study revealed an involvement of NF-kappaB and the CX3CL1/CX3CR1 axis in Tetanic Sciatic Stimulation-induced pathological pain. | Involvement of NF-κB and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation.
Wang ZC, Li LH, Bian C, Yang L, Lv N, Zhang YQ., Free PMC Article | 08/11/2018 |
| microglial CX3CR1/p38MAPK pathway is critical for the development of pain hypersensitivity after nicotine withdrawal | CX3CR1 Mediates Nicotine Withdrawal-Induced Hyperalgesia via Microglial P38 MAPK Signaling.
Ding Y, Shi W, Xie G, Yu A, Wang Q, Zhang Z. | 08/27/2016 |
| CX3CL1/CX3CR1 signaling is involved in LTP of C-fiber-evoked field potentials in the rodent spinal dorsal horn | Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation.
Bian C, Zhao ZQ, Zhang YQ, Lü N., Free PMC Article | 01/30/2016 |
| Results suggest fractalkine-CX3CR1 signaling pathway role in limbic seizure-induced hippocampal pathologies including microglial activation, neurodegeneration and neuroblast production | Role of fractalkine-CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain.
Ali I, Chugh D, Ekdahl CT. | 01/16/2016 |
| Results suggest that CX3C chemokine receptor 1 (CX3CR1) activation of pancreatic stellate cells (PSCs) could be important in their effects in pancreatitis, especially to PSCs proliferation in pancreatitis where CX3CL1 levels are elevated. | Pancreatic stellate cells and CX3CR1: occurrence in normal pancreas and acute and chronic pancreatitis and effect of their activation by a CX3CR1 agonist.
Uchida M, Ito T, Nakamura T, Hijioka M, Igarashi H, Oono T, Kato M, Nakamura K, Suzuki K, Takayanagi R, Jensen RT., Free PMC Article | 02/14/2015 |
| This is the first study to identify CX3CL1 signaling through CX3CR1 via the DRG/SC anatomical connection that represents a critical pathway involved in NPP induction in an EAE model of MS. | Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain.
Zhu W, Acosta C, MacNeil B, Cortes C, Intrater H, Gong Y, Namaka M., Free PMC Article | 06/14/2014 |
| It plays an important role in the neuroinflammatory response | Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency.
Wu J, Bie B, Yang H, Xu JJ, Brown DL, Naguib M. | 04/5/2014 |
| TMJ inflammation induced significant upregulation of CX3CR1 in the trigeminal subnucleus caudalis. | A functional relationship between trigeminal astroglial activation and NR1 expression in a rat model of temporomandibular joint inflammation.
Wang S, Song L, Tan Y, Ma Y, Tian Y, Jin X, Lim G, Zhang S, Chen L, Mao J., Free PMC Article | 06/1/2013 |
| The microglia CX3CR1/p38 MAP kinase signaling cascade potentially plays an important role in facilitating pain processing in rats with bone cancer pain. | Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord.
Hu JH, Yang JP, Liu L, Li CF, Wang LN, Ji FH, Cheng H. | 05/4/2013 |
| results showed fractalkine (FKN) and CX3CR1 were involved inflammatory response in cerulein-stimulated AR42J cells; FKN upregulates inflammation through CX3CR1 and the Jak/Stat pathway in severe acute pancreatitis rat models | Fractalkine upregulates inflammation through CX3CR1 and the Jak-Stat pathway in severe acute pancreatitis rat model.
Huang LY, Chen P, Xu LX, Zhou YF, Zhang YP, Yuan YZ. | 09/22/2012 |
| The fractalkine/CX3CR1 interaction may play an important role in the photoreceptor-microglia cross-talk in light-induced photoreceptor degeneration. | Role of fractalkine/CX3CR1 interaction in light-induced photoreceptor degeneration through regulating retinal microglial activation and migration.
Zhang M, Xu G, Liu W, Ni Y, Zhou W., Free PMC Article | 09/1/2012 |
| FKN, and its receptor, CX3CR1, may modulate cardiovascular responses in the solitary nucleus of normal healthy rats via the phosphoinositide 3-kinase intracellular signaling pathway. | A cardiovascular role for fractalkine and its cognate receptor, CX3CR1, in the rat nucleus of the solitary tract.
Ruchaya PJ, Paton JF, Murphy D, Yao ST. | 08/4/2012 |