| Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling. | Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling.
He X, Xu R, Pan L, Bhattarai U, Liu X, Zeng H, Chen JX, Hall ME, Chen Y., Free PMC Article | 08/10/2023 |
| Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice. | Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice.
Berriel E, Freire T, Chiale C, Rodríguez E, Morón G, Fernández-Graña G, Crispo M, Berois N, Osinaga E., Free PMC Article | 11/22/2021 |
| data showed that both Nkrp1b protein variants form monomers and homodimers irrespective of the presence of the stalk. | The C-type lectin-like receptor Nkrp1b: Structural proteomics reveals features affecting protein conformation and interactions.
Hernychová L, Rosůlek M, Kádek A, Mareška V, Chmelík J, Adámková L, Grobárová V, Šebesta O, Kukačka Z, Skála K, Spiwok V, Černý J, Novák P. | 05/23/2020 |
| Data suggest that expression of killer cell lectin-like receptor subfamily B member 1C protein (NK1.1) defines a population of rapidly expanding effector CD4(+) T cells that specifically promote plasmablast induction during Plasmodium infection. | NK1.1 Expression Defines a Population of CD4(+) Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection.
Wikenheiser DJ, Brown SL, Lee J, Stumhofer JS., Free PMC Article | 10/5/2019 |
| Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface. | Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
Adámková L, Kvíčalová Z, Rozbeský D, Kukačka Z, Adámek D, Cebecauer M, Novák P., Free PMC Article | 08/24/2019 |
| The adoptive transfer of NK1.1(-) CD4(+) NKG2D(+) cells suppressed DSS-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics. | NK1.1(-) CD4(+) NKG2D(+) T cells suppress DSS-induced colitis in mice through production of TGF-β.
Qian X, Hu C, Han S, Lin Z, Xiao W, Ding Y, Zhang Y, Qian L, Jia X, Zhu G, Gong W., Free PMC Article | 03/24/2018 |
| MCMV may encode a novel Clr-b-independent immunoevasin that functionally engages the NKR-P1B receptor. | Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.
Aguilar OA, Mesci A, Ma J, Chen P, Kirkham CL, Hundrieser J, Voigt S, Allan DS, Carlyle JR., Free PMC Article | 08/6/2016 |
| NK1.1+ CD8+ T cells have a role in TGF-beta control and contribute to early microbial pathogen response | NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response.
Ruiz AL, Soudja SM, Deceneux C, Lauvau G, Marie JC., Free PMC Article | 12/19/2015 |
| Data indicate that C-type lectin-like NK receptor NKR-P1C proteins showed no affinity to the various neoglycoproteins. | Re-evaluation of the involvement of NK cells and C-type lectin-like NK receptors in modulation of immune responses by multivalent GlcNAc-terminated oligosaccharides.
Grobárová V, Benson V, Rozbeský D, Novák P, Cerný J. | 07/26/2014 |
| 5-HT3 and NK1 immunopositive macrophages and mucosal mast cells in lamina propria release 5-HT and substance P, which in turn activate their corresponding receptors on mucosal cells in autocrine and paracrine manners. | Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.
Matsumoto K, Nakajima T, Sakai H, Kato S, Sagara A, Arakawa K, Tashima K, Narita M, Horie S. | 01/25/2014 |
| Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner | Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance.
Zhang Q, Rahim MM, Allan DS, Tu MM, Belanger S, Abou-Samra E, Ma J, Sekhon HS, Fairhead T, Zein HS, Carlyle JR, Anderson SK, Makrigiannis AP., Free PMC Article | 06/15/2013 |
| NK1.1-positive cells contribute to BCG-induced protective immunity to Mycobacterium tuberculosis through interactions with T cells in a mouse model. | NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.
Dhiman R, Periasamy S, Barnes PF, Jaiswal AG, Paidipally P, Barnes AB, Tvinnereim A, Vankayalapati R., Free PMC Article | 09/22/2012 |
| A functional dimeric form of the receptor is suggested, with the loop, evolutionarily conserved within this family, proposed to participate in interactions with ligands. | Molecular architecture of mouse activating NKR-P1 receptors.
Kolenko P, Rozbeský D, Vaněk O, Kopecký V Jr, Hofbauerová K, Novák P, Pompach P, Hašek J, Skálová T, Bezouška K, Dohnálek J. | 01/28/2012 |
| NK1.1(+) gammadeltaT cells function as inflammatory mediators in the early phase of IL-18/IL-2-induced interstitial lung disease | Involvement of NK 1.1-positive γδT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease.
Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T. | 11/12/2011 |
| CD11c-positive cells in the thyroid of CCL21 transgenic mice express the natural killer cell marker NK1.1, indicating their NK origin. | A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures.
Muniz LR, Pacer ME, Lira SA, Furtado GC., Free PMC Article | 09/24/2011 |
| The dual presence of interleukin (IL)-1beta and IL-23 induces rapid production of IL-17A, IL-17F, and IL-22 by peripheral lymph node NK1.1 invariant natural killer (NK)T cells in response to bacteria. | Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.
Doisne JM, Soulard V, Bécourt C, Amniai L, Henrot P, Havenar-Daughton C, Blanchet C, Zitvogel L, Ryffel B, Cavaillon JM, Marie JC, Couillin I, Benlagha K. | 02/26/2011 |
| Inflammation was similar in C57BL/6 and BALB/C mice, except for CD11b. Cellular colocalization of CD11b with NK1.1 indicates recruitment of NK cells in C57BL/6 mice. Congenic BALB.B6-Cmv1r mice showed the same endothelial response as BALB/c mice. | Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex.
Taherzadeh Z, VanBavel E, de Vos J, Matlung HL, van Montfrans G, Brewster LM, Seghers L, Quax PH, Bakker EN. | 04/19/2010 |
| Findings support the hypothesis that CCR6+ IL-17A-producing gammadelta T cells derive from less TCR-dependent selection events than IFN-gamma-producing NK1.1+ gammadelta T cells. | CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells.
Haas JD, González FH, Schmitz S, Chennupati V, Föhse L, Kremmer E, Förster R, Prinz I. | 01/21/2010 |
| Lactobacillus pentosus strain S-PT84 effectively promoted type 1 immunity through IL-12 and IFN-gamma which were produced by DCs and NK1.1(+) cells. | Essential role of Toll-like receptors for dendritic cell and NK1.1(+) cell-dependent activation of type 1 immunity by Lactobacillus pentosus strain S-PT84.
Koizumi S, Wakita D, Sato T, Mitamura R, Izumo T, Shibata H, Kiso Y, Chamoto K, Togashi Y, Kitamura H, Nishimura T. | 01/21/2010 |
| Bone marrow transplant rejection in congenic mice is regulated by haplotypes of the natural killer (NK) gene complex that encodes multiple NK cell receptors. | Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes.
Iizuka K, Scalzo AA, Xian H, Yokoyama WM. | 01/21/2010 |
| Thus, we present first evidence that NK1.1 surface expression on liver iNKT cells is reversible during L. monocytogenes infection, and that different mechanisms underlie stimulation by TCR and IL-12. | Reversible NK1.1 surface expression on invariant liver natural killer T cells during Listeria monocytogenes infection.
Emoto M, Yoshizawa I, Emoto Y, Takahashi Y, Hurwitz R, Miamoto M, Kaufmann SH. | 01/21/2010 |
| In a natural killer cell subset NK1.1(+) cells depended primarily on interleukin 15 and common cytokine receptor gamma chain signaling for their development. | Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells.
Blasius AL, Barchet W, Cella M, Colonna M., Free PMC Article | 01/21/2010 |
| Lactobacilli selectively activate CD1d-independent NK1.1+ T cells in the large intestine to produce IFN-gamma and therefore modulate Th1 immune responses | Activation of CD1d-independent NK1.1+ T cells in the large intestine by Lactobacilli.
Takahashi S, Kawamura T, Kanda Y, Taniguchi T, Nishizawa T, Iiai T, Hatakeyama K, Abo T. | 01/21/2010 |
| Engagement of NKR-P1C stimulates cytotoxicity of target cells, Ca2+ flux, phosphatidylinositol turnover, kinase activity, and cytokine production. In contrast, NKR-P1B engagement inhibits NK cell cytotoxicity. | Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors.
Ljutic B, Carlyle JR, Filipp D, Nakagawa R, Julius M, Zúñiga-Pflücker JC. | 01/21/2010 |
| results identify the minimal upstream cis-acting elements, and point to a complex regulatory mechanism involved in the lineage-specific control of NKR-P1C expression in NK lymphocytes | Identification of upstream cis-acting regulatory elements controlling lineage-specific expression of the mouse NK cell activation receptor, NKR-P1C.
Ljutic B, Carlyle JR, Zúñiga-Pflücker JC. | 01/21/2010 |