| Metabolic reprogramming contributes to radioprotection by protein kinase Cdelta. | Metabolic reprogramming contributes to radioprotection by protein kinase Cδ.
Ohm AM, Affandi T, Reisz JA, Caino MC, D'Alessandro A, Reyland ME., Free PMC Article | 06/5/2024 |
| Protein Kinase C-delta Mediates Kidney Tubular Injury in Cold Storage-Associated Kidney Transplantation. | Protein Kinase C-δ Mediates Kidney Tubular Injury in Cold Storage-Associated Kidney Transplantation.
Zhu J, Zhang G, Song Z, Xiang X, Shu S, Liu Z, Yang D, Wei Q, Dong Z., Free PMC Article | 01/2/2021 |
| Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis. | Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis.
Liverani E, Tursi SA, Cornwell WD, Mondrinos MJ, Sun S, Buttaro BA, Wolfson MR, Rogers TJ, Tükel Ç, Kilpatrick LE., Free PMC Article | 10/3/2020 |
| Chromatin immunoprecipitation revealed that AR could bind to Pkcd promoter. Our results indicate that prenatal exposure to testosterone may induce cardiac hypertrophy in adult female rats through enhanced Pkcd expression in cardiac myocytes. | Prenatal exposure to testosterone induces cardiac hypertrophy in adult female rats through enhanced Pkcδ expression in cardiac myocytes.
Hou M, Gu HC, Wang HH, Liu XM, Zhou CL, Yang Q, Jiang ZR, Lin J, Wu YM, Wu YT, Sheng JZ, Huang HF. | 06/20/2020 |
| These results confirmed that CaSR activated PKCdelta to induce cardiomyocyte apoptosis through ER stressassociated apoptotic pathways during I/R in vivo. | CaSR activates PKCδ to induce cardiomyocyte apoptosis via ER stress‑associated apoptotic pathways during ischemia/reperfusion.
Liu C, Li H, Zheng H, Zhai M, Lu F, Dong S, Fang T, Zhang W. | 01/11/2020 |
| Protein kinase D activation induces enhanced mitochondrial fragmentation and dysfunction in cardiomyocytes. | Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes.
Jhun BS, O-Uchi J, Adaniya SM, Mancini TJ, Cao JL, King ME, Landi AK, Ma H, Shin M, Yang D, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS., Free PMC Article | 08/24/2019 |
| PKC delta activation modulates neurotrophins levels by a signaling pathway that involves M1R activation and ultimately leading to an increase in retinal ganglion cells survival in vitro. | PKC delta activation increases neonatal rat retinal cells survival in vitro: Involvement of neurotrophins and M1 muscarinic receptors.
Braga LEG, Miranda RL, Granja MG, Giestal-de-Araujo E, Dos Santos AA. | 09/8/2018 |
| Authors demonstrate that YQFM ameliorates ischemic stroke-induced neuronal apoptosis through inhibiting mitochondrial dysfunction and PKCdelta/Drp1-mediated excessive mitochondrial fission. | YiQiFuMai Powder Injection Protects against Ischemic Stroke via Inhibiting Neuronal Apoptosis and PKCδ/Drp1-Mediated Excessive Mitochondrial Fission.
Xu Y, Wang Y, Wang G, Ye X, Zhang J, Cao G, Zhao Y, Gao Z, Zhang Y, Yu B, Kou J., Free PMC Article | 08/25/2018 |
| Results show that PKCdelta is activated in platelets during sepsis and that PKCdelta inhibition decreases sepsis-induced platelet activation and their interaction with leukocytes both systemically and in the lung in the cecal ligation and puncture model of sepsis in rats. | Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis.
Liverani E, Mondrinos MJ, Sun S, Kunapuli SP, Kilpatrick LE., Free PMC Article | 08/4/2018 |
| microRNA-133a can protect cardiomyocyte hypertrophy against norepinephrine stimulation in neonatal rat ventricular cardiomyocytes via new targets, PKCdelta and Gq, all of which are related to downstream signaling pathways of the alpha1-adrenergic receptor. | microRNA-133a attenuates cardiomyocyte hypertrophy by targeting PKCδ and Gq.
Lee SY, Lee CY, Ham O, Moon JY, Lee J, Seo HH, Shin S, Kim SW, Lee S, Lim S, Hwang KC. | 07/14/2018 |
| In a well-known rodent model of sepsis, the inhibition of PKCdelta attenuates neutrophil migration into the lung tissue in vivo. | A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction.
Soroush F, Zhang T, King DJ, Tang Y, Deosarkar S, Prabhakarpandian B, Kilpatrick LE, Kiani MF., Free PMC Article | 09/16/2017 |
| Enhanced activation of protein kinase C delta (PKCdelta) in vascular smooth muscle cell (VSMC) from hypertensive rats (SHR) increases the expression of G alpha protein q (Gqalpha) and phospholipase C beta1 (PLCbeta1) proteins and results in VSMC hypertrophy. | Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats.
Atef ME, Anand-Srivastava MB., Free PMC Article | 08/5/2017 |
| The findings suggested that periodic mechanical stress promoted chondrocyte proliferation through PKCdelta-EGFR-PI3K-Akt-ERK1/2. | Periodic Mechanical Stress Activates PKCδ-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2.
He P, Shen N, Gao G, Jiang X, Sun H, Zhou D, Xu N, Nong L, Ren K. | 02/4/2017 |
| the deltaPKC-dF1Fo inhibitor attenuated co-immunoprecipitation of deltaPKC with dF1Fo. | δPKC interaction with the d subunit of F1Fo ATP synthase impairs energetics and exacerbates ischemia/reperfusion injury in isolated rat hearts.
Walker M, Caldwell RW, Yoon Y, Nguyen TT, Johnson JA. | 10/1/2016 |
| Phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase. | A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ.
Gong J, Holewinski RJ, Van Eyk JE, Steinberg SF., Free PMC Article | 06/28/2016 |
| PRKCBII and PRKCD-dependent inactivation of p38 regulates cardiac fibroblast proliferation and collagen deposition in response to angiotensin II. | PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.
Chichger H, Vang A, O'Connell KA, Zhang P, Mende U, Harrington EO, Choudhary G., Free PMC Article | 01/2/2016 |
| Studied role of melatonin in modulating P-type Ca(2+) channels and action-potential firing in rat Purkinje neurons and found melatonin application increased the membrane abundance of PKCdelta, and PKCdelta inhibition abolished the melatonin-induced IBa response. | Melatonin-mediated inhibition of Purkinje neuron P-type Ca²⁺ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway.
Zhang Y, Li H, Pu Y, Gong S, Liu C, Jiang X, Tao J. | 12/19/2015 |
| Studies identify a C2 domain pTyr313 docking interaction that controls ATP-positioning loop phosphorylation as a novel, dynamically regulated, and physiologically relevant structural determinant of PKCdelta catalytic activity. | The C2 Domain and Altered ATP-Binding Loop Phosphorylation at Ser³⁵⁹ Mediate the Redox-Dependent Increase in Protein Kinase C-δ Activity.
Gong J, Yao Y, Zhang P, Udayasuryan B, Komissarova EV, Chen J, Sivaramakrishnan S, Van Eyk JE, Steinberg SF., Free PMC Article | 07/26/2015 |
| Emodin attenuates tonic tension through the blockade of PKCdelta and CPI-17-mediated MLC-phosphatase inhibition. | Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta.
Lim KM, Kwon JH, Kim K, Noh JY, Kang S, Park JM, Lee MY, Bae ON, Chung JH., Free PMC Article | 05/30/2015 |
| Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cdelta-mediated mechanism. | Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism.
Blesson CS, Chinnathambi V, Hankins GD, Yallampalli C, Sathishkumar K., Free PMC Article | 04/18/2015 |
| our results demonstrate that PKCd phosphorylation at Ser/Tyr plays a critical role in the modulation of gastric mucosal inflammatory responses to H. pylori LPS by ghrelin | Modulation of gastric mucosal inflammatory responses to Helicobacter pylori via ghrelin-induced protein kinase Cδ tyrosine phosphorylation.
Slomiany BL, Slomiany A. | 03/7/2015 |
| Three subtypes, PKC-delta, PKC-gamma and PKC-alpha are likely to be involved the phosphorylation suppression of ERK included cyclic guanosine monophosphate. | The cross talk between cGMP signal pathway and PKC in pulmonary endothelial cell angiogenesis.
Zeng Z, Li YC, Jiao ZH, Yao J, Xue Y., Free PMC Article | 01/31/2015 |
| The Prkcd pathway induces MMP-9 expression which is required for brain astrocyte migration. | C-Src/Jak2/PDGFR/PKCδ-dependent MMP-9 induction is required for thrombin-stimulated rat brain astrocytes migration.
Lin CC, Lee IT, Chi PL, Hsieh HL, Cheng SE, Hsiao LD, Liu CJ, Yang CM. | 11/22/2014 |
| These results identified PKCdelta as an essential PKC isoform involved in the activation of SOCE, and confirmed that PKC regulates the function of ASMCs in a SOCE-dependent manner. | Role of protein kinase C in the activation of store-operated Ca(2+) entry in airway smooth muscle cells.
Gao Y, Zou J, Geng S, Zheng J, Yang J. | 09/13/2014 |
| Data suggest that PKC delta, rather than classic-type PKC (alpha, beta1, beta2, gamma), participates in 6-OHDA-induced neurotoxicity in PC12 cells, and PKC delta activity is required for subsequent ERK activation during cell death | Protein kinase C delta mediated cytotoxicity of 6-Hydroxydopamine via sustained extracellular signal-regulated kinase 1/2 activation in PC12 cells.
Fan Y, Li J, Zhang YQ, Jiang LH, Zhang YN, Yan CQ. | 09/6/2014 |