| TNF/Lymphotoxin alpha/beta deficiency influences PM2.5 exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure. | Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM(2.5).
Hu Z, Chen M, Zhou H, Tharakan A, Wang X, Qiu L, Liang S, Qin X, Zhang Y, Wang W, Xu Y, Ying Z., Free PMC Article | 10/28/2017 |
| The expression of lymphotoxin (LT)-B was significantly downregulated in the absence of T cells from nude mice and was recovered after the transfusion of T cells. | T lymphocytes maintain structure and function of fibroblastic reticular cells via lymphotoxin (LT)-B.
Zhao L, Liu L, Gao J, Yang Y, Hu C, Guo B, Zhu B., Free PMC Article | 05/23/2015 |
| Expression of LT alpha and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP associated secondary extra pancreatic pathologies. | The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.
Seleznik GM, Zoller J, O'Connor T, Graf R, Heikenwalder M. | 01/17/2015 |
| TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter. | TNF-inducible expression of lymphotoxin-β in hepatic cells: an essential role for NF-κB and Ets1 transcription factors.
Subrata LS, Voon DC, Yeoh GC, Ulgiati D, Quail EA, Abraham LJ. | 02/23/2013 |
| Lymphotoxin-beta-receptor (LTbetaR) signaling, a pathway essential for lymphoid organogenesis, abrogates tertiary lymphoid organ development in heart transplantation. | Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses.
Motallebzadeh R, Rehakova S, Conlon TM, Win TS, Callaghan CJ, Goddard M, Bolton EM, Ruddle NH, Bradley JA, Pettigrew GJ. | 03/3/2012 |
| cigarette smoke induces pulmonary expression of lymphoid chemokines CXCL13 and CCL19 in a LTalphabeta-LTbetaR-dependent fashion | Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis.
Demoor T, Bracke KR, Maes T, Vandooren B, Elewaut D, Pilette C, Joos GF, Brusselle GG. | 01/21/2010 |
| Sustained LT signaling represents a pathway involved in hepatitis-induced hepatocellular carcinoma. | A lymphotoxin-driven pathway to hepatocellular carcinoma.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M., Free PMC Article | 01/21/2010 |
| The adaptive immune system directly regulates liver regeneration via a T cell-derived lymphotoxin axis (LTalpha, LTbeta, LTbetaR). | T cell-derived lymphotoxin regulates liver regeneration.
Tumanov AV, Koroleva EP, Christiansen PA, Khan MA, Ruddy MJ, Burnette B, Papa S, Franzoso G, Nedospasov SA, Fu YX, Anders RA., Free PMC Article | 01/21/2010 |
| LTbetaR on hepatic stellate cells may be involved in signaling with LTbeta-expressing liver progenitor cells mediating recruitment of progenitor cells, hepatic stellate cells, & leukocytes for wound healing & regeneration during chronic liver injury. | Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury.
Ruddell RG, Knight B, Tirnitz-Parker JE, Akhurst B, Summerville L, Subramaniam VN, Olynyk JK, Ramm GA. | 01/21/2010 |
| The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells. | Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner.
Vondenhoff MF, Desanti GE, Cupedo T, Bertrand JY, Cumano A, Kraal G, Mebius RE, Golub R. | 01/21/2010 |
| Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. | Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function.
Summers-DeLuca LE, McCarthy DD, Cosovic B, Ward LA, Lo CC, Scheu S, Pfeffer K, Gommerman JL., Free PMC Article | 01/21/2010 |
| signal was essential for primary B cell cluster formation with initial differentiation of follicular dendritic cells (FDCs) in neonatal mice. | Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs.
Qin J, Konno H, Ohshima D, Yanai H, Motegi H, Shimo Y, Hirota F, Matsumoto M, Takaki S, Inoue J, Akiyama T. | 01/21/2010 |
| LTbeta shows a primary early function in periderm differentiation, with later transient effects on epidermal and hair follicle differentiation. | Lymphotoxin-beta regulates periderm differentiation during embryonic skin development.
Cui CY, Kunisada M, Esibizione D, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. | 01/21/2010 |
| Activation of LTbetaR by LTalphabeta mainly expressed on T lymphocytes is crucial for the down regulation of the inflammatory response in this experimental model. | Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes.
Jungbeck M, Stopfer P, Bataille F, Nedospasov SA, Männel DN, Hehlgans T. | 01/21/2010 |
| membrane lymphotoxin beta contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs | Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs.
Wilhelm P, Riminton DS, Ritter U, Lemckert FA, Scheidig C, Hoek R, Sedgwick JD, Körner H. | 01/21/2010 |
| The organogenic function of B-LTbeta is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response. | Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues.
Tumanov A, Kuprash D, Lagarkova M, Grivennikov S, Abe K, Shakhov A, Drutskaya L, Stewart C, Chervonsky A, Nedospasov S. | 01/21/2010 |
| microenvironment in peripheral lymphoid organs associated with lymphotoxin alpha/lymphotoxin beta-lymphotoxin beta receptor signaling and chemokine production is critical for recruitment efficiency of dendritic cel | Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo.
Abe K, Yarovinsky FO, Murakami T, Shakhov AN, Tumanov AV, Ito D, Drutskaya LN, Pfeffer K, Kuprash DV, Komschlies KL, Nedospasov SA. | 01/21/2010 |
| membrane LT-beta is important in resistance to Theiler's virus infection | Membrane lymphotoxin is required for resistance to Theiler's virus infection.
Lin X, Ma X, Rodriguez M, Feng X, Zoecklein L, Fu YX, Roos RP. | 01/21/2010 |
| Data show that, as an ectodysplasin target, lymphotoxin-beta regulates hair phenotype in developing hair follicles. | Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.
Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D., Free PMC Article | 01/21/2010 |
| Expression of LTbeta on lymphocytes enhances the induction of immune responses against limiting amounts of antigen | Expression of lymphotoxin beta governs immunity at two distinct levels.
Junt T, Tumanov AV, Harris N, Heikenwalder M, Zeller N, Kuprash DV, Aguzzi A, Ludewig B, Nedospasov SA, Zinkernagel RM. | 01/21/2010 |
| LTbeta RNA is detectable in embryos ranging from 5.5 to 18.5 days of development, e.g., in peripheral lymph nodes, Peyer's patches, thymus and skin of the E18.5 embryo and fetal liver of E12.5. | Visualization of lymphotoxin-beta and lymphotoxin-beta receptor expression in mouse embryos.
Browning JL, French LE. | 01/21/2010 |
| Contributes to nasal-associated lymphoid tissue development and function through regulation of lymphoid chemokines and adhesion molecules. | Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressin.
Ying X, Chan K, Shenoy P, Hill M, Ruddle NH., Free PMC Article | 01/21/2010 |
| LTbeta, LTbeta receptor, and IFNgamma are involved in oval cell-mediated, but not hepatocyte-mediated, liver regeneration, and the absence of these pathways impairs the oval cell-dependent regenerative response. | Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury.
Akhurst B, Matthews V, Husk K, Smyth MJ, Abraham LJ, Yeoh GC. | 01/21/2010 |
| The lymphotoxin beta signaling pathway is an essential effector pathway for host defense against the beta-herpesvirus muromegalovirus (MCMV). | A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection.
Banks TA, Rickert S, Benedict CA, Ma L, Ko M, Meier J, Ha W, Schneider K, Granger SW, Turovskaya O, Elewaut D, Otero D, French AR, Henry SC, Hamilton JD, Scheu S, Pfeffer K, Ware CF. | 01/21/2010 |
| Data show that signaling of lymphotoxin (LT) alphabeta through the LTbeta receptor (LTbetaR) is indispensable for regulating peripheral but not thymic Valpha14i NKT cell numbers. | A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells.
Franki AS, Van Beneden K, Dewint P, Hammond KJ, Lambrecht S, Leclercq G, Kronenberg M, Deforce D, Elewaut D., Free PMC Article | 01/21/2010 |