| Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68. | Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68.
Xu X, Shobuike T, Shiraki M, Kamohara A, Hirata H, Murayama M, Mawatari D, Ueno M, Morimoto T, Kukita T, Mawatari M, Kukita A. | 09/3/2022 |
| Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1. | Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1.
Zhou JP, Ren YD, Xu QY, Song Y, Zhou F, Chen MY, Liu JJ, Chen LG, Pan JS., Free PMC Article | 09/26/2020 |
| Intragenic antagonistic roles of protein and circRNA in tumorigenesis. | Intragenic antagonistic roles of protein and circRNA in tumorigenesis.
Guarnerio J, Zhang Y, Cheloni G, Panella R, Mae Katon J, Simpson M, Matsumoto A, Papa A, Loretelli C, Petri A, Kauppinen S, Garbutt C, Nielsen GP, Deshpande V, Castillo-Martin M, Cordon-Cardo C, Dimitrios S, Clohessy JG, Batish M, Pandolfi PP., Free PMC Article | 08/22/2020 |
| widely used promoter factor that transduces signals from other transcription factors to enable control of accessibility and regulation of gene expression | Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.
Ramos Pittol JM, Oruba A, Mittler G, Saccani S, van Essen D., Free PMC Article | 04/20/2019 |
| LRF is expressed mainly in oligodendrocytes but is not required for oligodendrocyte repopulation of demyelinated lesions. Furthermore, LRF can modulate the extent of remyelination, potentially by contributing to interactions regulating transcription | Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination.
Davidson NL, Yu F, Kijpaisalratana N, Le TQ, Beer LA, Radomski KL, Armstrong RC., Free PMC Article | 06/9/2018 |
| Alveolar macrophages deficient in Zbtb7a failed to induce antibody and T cell responses. | Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.
Nayak DK, Zhou F, Xu M, Huang J, Tsuji M, Yu J, Hachem R, Gelman AE, Bremner RM, Smith MA, Mohanakumar T., Free PMC Article | 03/31/2018 |
| this study shows that Thpok and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool | Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.
Carpenter AC, Wohlfert E, Chopp LB, Vacchio MS, Nie J, Zhao Y, Shetty J, Xiao Q, Deng C, Tran B, Cam M, Gaida MM, Belkaid Y, Bosselut R., Free PMC Article | 09/30/2017 |
| This study identified Zbtb7a as a novel direct target for miR-125a by gene expression profiling in miR-125a knockout mice combined with bioinformatics target prediction, and elucidated the role of Zbtb7a in oncogenesis. | A Zbtb7a proto-oncogene as a novel target for miR-125a.
Hojo N, Tatsumi N, Moriguchi N, Matsumura A, Morimoto S, Nakata J, Fujiki F, Nishida S, Nakajima H, Tsuboi A, Oka Y, Hosen N, Hayashi S, Sugiyama H, Oji Y. | 09/9/2017 |
| This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair. | LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP., Free PMC Article | 05/7/2016 |
| LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells. | Attenuation of Leukemia/Lymphoma-Related Factor Protein Expression Inhibits Glioma Cell Proliferation and Invasion.
Huang R, Xie T, Zhao Y, Yao CS. | 08/22/2015 |
| Data indicate that transcription factors Thpok and LRF redundantly maintain CD4+ lineage integrity. | A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells.
Vacchio MS, Wang L, Bouladoux N, Carpenter AC, Xiong Y, Williams LC, Wohlfert E, Song KD, Belkaid Y, Love PE, Bosselut R., Free PMC Article | 12/20/2014 |
| Findings demonstrate that Pokemon suppresses Sprouty1 expression through a miR-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells. | microRNA 21-mediated suppression of Sprouty1 by Pokemon affects liver cancer cell growth and proliferation.
Jin XL, Sun QS, Liu F, Yang HW, Liu M, Liu HX, Xu W, Jiang YY. | 11/2/2013 |
| Data show that Notch1/Dll4-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment. | LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.
Lee SU, Maeda M, Ishikawa Y, Li SM, Wilson A, Jubb AM, Sakurai N, Weng L, Fiorini E, Radtke F, Yan M, Macdonald HR, Chen CC, Maeda T., Free PMC Article | 04/6/2013 |
| These results support a critical role for LRF in transcriptional control of differentiation in oligodendrocyte lineage cells during developmental myelination in the CNS. | Leukemia/lymphoma-related factor regulates oligodendrocyte lineage cell differentiation in developing white matter.
Dobson NR, Moore RT, Tobin JE, Armstrong RC. | 01/26/2013 |
| T cells lacking Thpok, which only displayed LRF-dependent functions, contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extracellular parasites | The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.
Carpenter AC, Grainger JR, Xiong Y, Kanno Y, Chu HH, Wang L, Naik S, dos Santos L, Wei L, Jenkins MK, O'Shea JJ, Belkaid Y, Bosselut R., Free PMC Article | 12/29/2012 |
| study shows that LRF plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment | Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Tsuji-Takechi K, Negishi-Koga T, Sumiya E, Kukita A, Kato S, Maeda T, Pandolfi PP, Moriyama K, Takayanagi H., Free PMC Article | 04/21/2012 |
| Data demonstrate that the transcription factor leukemia/lymphoma-related factor (LRF) forms an obligate dimer in B cells and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms. | The LRF transcription factor regulates mature B cell development and the germinal center response in mice.
Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T., Free PMC Article | 10/15/2011 |
| analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF) and alternative splicing factor/splicing factor 2 (ASF/SF2) affects cell senescence and apoptosis | MicroRNA (miRNA)-mediated interaction between leukemia/lymphoma-related factor (LRF) and alternative splicing factor/splicing factor 2 (ASF/SF2) affects mouse embryonic fibroblast senescence and apoptosis.
Verduci L, Simili M, Rizzo M, Mercatanti A, Evangelista M, Mariani L, Rainaldi G, Pitto L., Free PMC Article | 01/15/2011 |
| LRF is post-transcriptionally regulated by miR-20a. | The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence.
Poliseno L, Pitto L, Simili M, Mariani L, Riccardi L, Ciucci A, Rizzo M, Evangelista M, Mercatanti A, Pandolfi PP, Rainaldi G., Free PMC Article | 01/21/2010 |
| Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene | Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).
Choi WI, Jeon BN, Park H, Yoo JY, Kim YS, Koh DI, Kim MH, Kim YR, Lee CE, Kim KS, Osborne TF, Hur MW., Free PMC Article | 01/21/2010 |
| may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation | Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis.
Laudes M, Christodoulides C, Sewter C, Rochford JJ, Considine RV, Sethi JK, Vidal-Puig A, O'Rahilly S., Free PMC Article | 01/21/2010 |
| LRF is the first transcription factor found to bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation | Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.
Liu CJ, Prazak L, Fajardo M, Yu S, Tyagi N, Di Cesare PE. | 01/21/2010 |
| findings demonstrate that LRF is key for instructing early lymphoid progenitors to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch | Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.
Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP., Free PMC Article | 01/21/2010 |
| Pokemon can specifically repress the transcription of the tumour suppressor gene ARF through direct binding | Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.
Maeda T, Hobbs RM, Merghoub T, Guernah I, Zelent A, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP. | 01/21/2010 |