| Lymphocyte-Specific Protein Tyrosine Kinase Contributes to Spontaneous Regression of Liver Fibrosis may by Interacting with Suppressor of Cytokine Signaling 1. | Lymphocyte-Specific Protein Tyrosine Kinase Contributes to Spontaneous Regression of Liver Fibrosis may by Interacting with Suppressor of Cytokine Signaling 1.
Zhao H, Zhu H, Zhang Y, Ding Y, Feng R, Li J, Ma T, Huang C. | 11/3/2023 |
| LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer. | LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O., Free PMC Article | 06/30/2023 |
| [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR]. | [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR].
Hivroz C. | 02/4/2023 |
| LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis. | LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis.
Hwang SM, Ha YJ, Koo GB, Noh HJ, Lee AY, Kim BJ, Hong SM, Morgan MJ, Eyun SI, Lee D, Roe JS, Lee Y, Kim YS., Free PMC Article | 11/19/2022 |
| Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis. | Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.
Zhou J, Zhang X, Ji L, Jiang G., Free PMC Article | 04/2/2022 |
| CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice. | CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice.
Duan H, Jing L, Jiang X, Ma Y, Wang D, Xiang J, Chen X, Wu Z, Yan H, Jia J, Liu Z, Feng J, Zhu M, Yan X., Free PMC Article | 12/11/2021 |
| Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia. | Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia.
Märklin M, Fuchs AR, Tandler C, Heitmann JS, Salih HR, Kauer J, Quintanilla-Martinez L, Wirths S, Kopp HG, Müller MR., Free PMC Article | 05/1/2021 |
| Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells. | Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells.
Horkova V, Drobek A, Mueller D, Gubser C, Niederlova V, Wyss L, King CG, Zehn D, Stepanek O., Free PMC Article | 03/20/2021 |
| Lck bound to coreceptor is less active than free Lck. | Lck bound to coreceptor is less active than free Lck.
Wei Q, Brzostek J, Sankaran S, Casas J, Hew LS, Yap J, Zhao X, Wojciech L, Gascoigne NRJ., Free PMC Article | 09/5/2020 |
| LCK cooperates with oncogenic FLT3-ITD in cellular transformation | The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation.
Marhäll A, Kazi JU, Rönnstrand L., Free PMC Article | 07/6/2019 |
| Data show that protein tyrosine kinase p56(lck) (Lck) expression is higher in Th1 cells as compared to Th2 cells. | Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun.
Shebzukhov YV, Stanislawiak S, Bezhaeva TR, Nedospasov SA, Kuprash DV., Free PMC Article | 12/22/2018 |
| LCK nitration inhibits T cell activation, leading to reduced interleukin 2 (IL2) production and proliferation. | Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers.
Feng S, Cheng X, Zhang L, Lu X, Chaudhary S, Teng R, Frederickson C, Champion MM, Zhao R, Cheng L, Gong Y, Deng H, Lu X., Free PMC Article | 10/20/2018 |
| Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck complex of protein kinase Ctheta; (PKCtheta;), which serves as a key effector kinase in the CD28 signaling pathway. | Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA, Sharpe AH, Wucherpfennig KW., Free PMC Article | 11/25/2017 |
| A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity. | A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A., Free PMC Article | 09/30/2017 |
| We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice) | lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.
Carow B, Gao Y, Coquet J, Reilly M, Rottenberg ME. | 08/19/2017 |
| this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity | Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.
Moogk D, Zhong S, Yu Z, Liadi I, Rittase W, Fang V, Dougherty J, Perez-Garcia A, Osman I, Zhu C, Varadarajan N, Restifo NP, Frey AB, Krogsgaard M., Free PMC Article | 08/12/2017 |
| this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development | T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages.
Chiang YJ, Hodes RJ., Free PMC Article | 07/1/2017 |
| Aurora A inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck active during T-cell activation. | Aurora A drives early signalling and vesicle dynamics during T-cell activation.
Blas-Rus N, Bustos-Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F., Free PMC Article | 09/10/2016 |
| essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells | Regulation of T cell development by c-Cbl: essential role of Lck.
Chiang YJ, Hodes RJ., Free PMC Article | 01/30/2016 |
| Lck-Dlx5 mice develop T-ALLs that consistently acquire overexpression of Myc and activation of Akt. | Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.
Tan Y, Sementino E, Pei J, Kadariya Y, Ito TK, Testa JR., Free PMC Article | 01/23/2016 |
| Lck-CD8 interaction is required for initial CD8 recruitment. | Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR., Free PMC Article | 10/17/2015 |
| The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. | The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sørlie M, Spurkland A. | 08/15/2015 |
| CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck | The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck.
Roh KH, Lillemeier BF, Wang F, Davis MM., Free PMC Article | 06/27/2015 |
| lymphoid cell kinase is the crucial effector of beta1-integrin signalling in Schwann cells | Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination.
Ness JK, Snyder KM, Tapinos N., Free PMC Article | 01/4/2014 |
| Study concludes that the intracellular state of Lck Study conclude that the intracellular state of Lck determines the specificity of thymic selection and that Lck association with coreceptor proteins during thymic selection is the mechanism by which MHC restriction is imposed on a randomly generated alphabetaTCR repertoire. | Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A., Free PMC Article | 11/30/2013 |