| E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation. | E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation.
Liu W, Wang Y, Liu S, Zhang X, Cao X, Jiang M., Free PMC Article | 09/9/2024 |
| Gut-licensed IFNgamma(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes. | Gut-licensed IFNγ(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes.
Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ., Free PMC Article | 11/6/2021 |
| Hyperglycosylated LAMP1 is associated with the neuro-inflammatory phenotype of Niemann-Pick disease, type C. | Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology.
Cawley NX, Sojka C, Cougnoux A, Lyons AT, Nicoli ER, Wassif CA, Porter FD., Free PMC Article | 04/18/2020 |
| Transcriptomic and bioinformatic analysis during autophagy in RAW264.7 macrophages revealed interaction of metastasis-associated lung adenocarcinoma transcript-1 (Malat1) lncRNA with microRNA (mir)-23-3p and lysosomal-associated membrane protein 1 (Lamp1). Malat1 releases inhibition of Lamp1 expression in macrophages through competitive adsorption of mir-23-3p. | LncRNA expression profile during autophagy and Malat1 function in macrophages.
Ma Z, Zhang J, Xu X, Qu Y, Dong H, Dang J, Huo Z, Xu G., Free PMC Article | 04/4/2020 |
| By whole-mount immunofluorescence on postnatal day 3 mouse cochlea, we show its expression in outer (OHC) and inner (IHC) hair cells cytosol co-localizing with Lamp-1 in lysosomes. Furthermore, we provide evidence that the variant alters the PDE1C hydrolytic activity for both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) | A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.
Wang L, Feng Y, Yan D, Qin L, Grati M, Mittal R, Li T, Sundhari AK, Liu Y, Chapagain P, Blanton SH, Liao S, Liu X., Free PMC Article | 03/30/2019 |
| larger autophagic vacuoles that colocalize with early endosome antigen 1 (EEA1) but not with lysosomal-associated membrane protein (LAMP)-1 were much more frequently formed in Rab7(Deltapan) pancreatic acinar cells. | Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.
Takahashi K, Mashima H, Miura K, Maeda D, Goto A, Goto T, Sun-Wada GH, Wada Y, Ohnishi H., Free PMC Article | 12/22/2018 |
| LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells. | LIN28A inhibits lysosome‑associated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells.
Pan P, Chen T, Zhang Y, Qi Z, Qin J, Cui G, Guo X. | 10/20/2018 |
| Both LAMP-1 and LAMP-2 are involved in C2C12 myotube formation and LAMP-2 may contribute dominantly to it. | The Major Lysosomal Membrane Proteins LAMP-1 and LAMP-2 Participate in Differentiation of C2C12 Myoblasts.
Sakane H, Akasaki K. | 10/20/2018 |
| A recombinant DNA vaccine, pVAX-LAMP/Gn was previously proved efficient, requiring long-term evaluations. pVAX-LAMP/Gn established memory responses within a long-term protection. Lysosome-targeted strategy showed promise on Gn-based DNA vaccine and further investigations are warranted in other immunogenic Hantaviral antigens. | Recombinant DNA vaccine of Hantavirus Gn and LAMP1 induced long-term immune protection in mice.
Jiang DB, Sun LJ, Cheng LF, Zhang JP, Xiao SB, Sun YJ, Yang SY, Wang J, Zhang FL, Yang K. | 11/25/2017 |
| The results presented here show the major role of LAMP-2 in caveolin traffic and membrane repair and consequently in T. cruzi invasion. | LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion.
Couto NF, Pedersane D, Rezende L, Dias PP, Corbani TL, Bentini LC, Oliveira ACS, Kelles LF, Castro-Gomes T, Andrade LO., Free PMC Article | 07/15/2017 |
| Here, we identify lamellar inclusions as the subcellular site of lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, which may cause gradual neurodegeneration, and we reveal how beta-cyclodextrin, a potential therapeutic drug, reverts these changes. Our study provides new mechanistic insight in NPC disease and uncovers new targets for therapeutic approaches. | Reversal of Pathologic Lipid Accumulation in NPC1-Deficient Neurons by Drug-Promoted Release of LAMP1-Coated Lamellar Inclusions.
Demais V, Barthélémy A, Perraut M, Ungerer N, Keime C, Reibel S, Pfrieger FW., Free PMC Article | 07/15/2017 |
| we demonstrate that galectin-3 induces MMP9 expression via p38 MAP-kinase pathway. LAMP1 was demonstrated to serve as one of the key mediators of galectin-3-induced MMP9 expression via p38 MAPK pathway | Extracellular galectin-3 induces MMP9 expression by activating p38 MAPK pathway via lysosome-associated membrane protein-1 (LAMP1).
Dange MC, Agarwal AK, Kalraiya RD. | 01/30/2016 |
| Although surface LAMP1 promotes interactions with organ ECM and BM, carbohydrates on LAMP1 play a decisive role in dictating lung metastasis. | Role of tumor cell surface lysosome-associated membrane protein-1 (LAMP1) and its associated carbohydrates in lung metastasis.
Agarwal AK, Srinivasan N, Godbole R, More SK, Budnar S, Gude RP, Kalraiya RD. | 11/28/2015 |
| LAMP luminal domain also showed to be essential for Gag traffic through lysosomes. | Regulation of HIV-Gag expression and targeting to the endolysosomal/secretory pathway by the luminal domain of lysosomal-associated membrane protein (LAMP-1) enhance Gag-specific immune response.
Godinho RM, Matassoli FL, Lucas CG, Rigato PO, Gonçalves JL, Sato MN, Maciel M Jr, Peçanha LM, August JT, Marques ET Jr, de Arruda LB., Free PMC Article | 01/31/2015 |
| The results thus for the first time provide direct evidence that cell surface LAMP1 facilitates lung metastasis by providing ligands for galectin-3 which has been shown to be expressed in highest amounts on lungs and constitutively on its vascular endothelium. | Regulation of melanoma metastasis to lungs by cell surface Lysosome Associated Membrane Protein-1 (LAMP1) via galectin-3.
Agarwal AK, Gude RP, Kalraiya RD. | 08/9/2014 |
| Caveolin-1 associated adenovirus entry into human corneal cells. | Caveolin-1 associated adenovirus entry into human corneal cells.
Yousuf MA, Zhou X, Mukherjee S, Chintakuntlawar AV, Lee JY, Ramke M, Chodosh J, Rajaiya J., Free PMC Article | 08/9/2014 |
| study has shown that Lassa virus entry requires a pH-regulated engagement of alpha-DG and LAMP1 both of which need to be glycosylated | Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR., Free PMC Article | 07/12/2014 |
| CD107a/LAMP-1 has a role in the protection of NK cells from degranulation-associated suicide | Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.
Cohnen A, Chiang SC, Stojanovic A, Schmidt H, Claus M, Saftig P, Janßen O, Cerwenka A, Bryceson YT, Watzl C. | 11/16/2013 |
| LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles. | The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.
Demirel Ö, Jan I, Wolters D, Blanz J, Saftig P, Tampé R, Abele R. | 04/27/2013 |
| a novel mechanism showing how Salmonella acquires LAMP1 through a SipC-Syntaxin6-mediated interaction probably to stabilize their niche in macrophages | Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6.
Madan R, Rastogi R, Parashuraman S, Mukhopadhyay A., Free PMC Article | 04/14/2012 |
| The kinetic observations provide sufficient quantitative evidence that in P338D(1) cells the bulk of newly-synthesized endogenous LAMP-1 first appeared in early endosomes, before it was delivered to late endosomes and lysosomes about 25 min later. | Kinetic evidence that newly-synthesized endogenous lysosome-associated membrane protein-1 (LAMP-1) first transits early endosomes before it is delivered to lysosomes.
Ebrahim R, Thilo L. | 08/6/2011 |
| The finding raises the possibility that the expression of SSEA-1-positive LAMP-1 is associated with the "stemness" of neural stem cells. | Lysosome-associated membrane protein 1 is a major SSEA-1-carrier protein in mouse neural stem cells.
Yagi H, Yanagisawa M, Kato K, Yu RK., Free PMC Article | 01/1/2011 |
| Using LAMP1/2 knock out cells the authors show that these two proteins are important for Trypanosoma cruzi infection of host cells, both in entrance and intracellular development, conceivably by being the major source of sialic acid for Trypanosoma cruzi. | Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development.
Albertti LA, Macedo AM, Chiari E, Andrews NW, Andrade LO., Free PMC Article | 12/11/2010 |
| LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts | Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells.
Zhang H, Tompkins K, Garrigues J, Snead ML, Gibson CW, Somerman MJ., Free PMC Article | 08/16/2010 |
| Our results suggested that the increase in LAMP-1 was enhanced by the accumulation of amyloid-beta occurring during aging. Our findings coincided with the pathological hallmarks of Alzheimer's disease. | Age-dependent increase in lysosome-associated membrane protein 1 and early-onset behavioral deficits in APPSL transgenic mouse model of Alzheimer's disease.
Hashimoto T, Ogino K, Shin RW, Kitamoto T, Kikuchi T, Shimizu N. | 04/19/2010 |