| Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia | Endometrial Polyps and Benign Endometrial Hyperplasia Have Increased Prevalence of DNA Fragmentation Factors 40 and 45 (DFF40 and DFF45) Together With the Antiapoptotic B-Cell Lymphoma (Bcl-2) Protein Compared With Normal Human Endometria.
Banas T, Pitynski K, Mikos M, Cielecka-Kuszyk J. | 12/22/2018 |
| evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients | Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study.
Fawzy MS, Toraih EA, Ibrahiem A, Abdeldayem H, Mohamed AO, Abdel-Daim MM., Free PMC Article | 12/9/2017 |
| Data show that the caspase-activated DNase (CAD) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis. | Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.
Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA., Free PMC Article | 10/31/2015 |
| Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer. | siRNA-mediated knock-down of DFF45 amplifies doxorubicin therapeutic effects in breast cancer cells.
Bagheri F, Safarian S, Eslaminejad MB, Sheibani N. | 08/9/2014 |
| ICAD deficiency was associated with severe genomic instability. | ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability.
Errami Y, Brim H, Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Davis CJ, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares AH., Free PMC Article | 01/25/2014 |
| mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim, Bcl-x, and ICAD in Pnn-depleted MCF-7 cells. | Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD.
Leu S, Lin YM, Wu CH, Ouyang P. | 01/26/2013 |
| The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause. | DFF45 expression in human endometrium is associated with menstrual cycle phases and decreases after menopause.
Banas T, Basta P, Knafel A, Skotniczny K, Jach R, Hajdyla-Banas I, Grabowska O. | 08/25/2012 |
| study reveals a previously unrecognized function of miR-145 in DFF45 processing, which may underlie crucial aspects of cancer biology | MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network.
Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, Chen W., Free PMC Article | 12/11/2010 |
| The heterodimer, DFF40-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions. | Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells.
Ninios YP, Sekeri-Pataryas KE, Sourlingas TG. | 05/10/2010 |
| A decreased level of DFF45 observed in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. | DFF45 expression in ovarian endometriomas.
Banas T, Skotniczny K, Basta A. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. | 04/1/2009 |
| MPP(+) did not change the total levels of c-Jun but enhanced phosphorylation of c-Jun at Ser73 and cleavage of DNA fragmentation factor 45, which were diminished by selegiline. | 1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline.
Chetsawang B, Kooncumchoo P, Govitrapong P, Ebadi M. | 01/21/2010 |
| The highest level of DFF45 endometrial expression was found during the early secretory cycle phase, and significantly lower DFF45 expression was found in the endometrium during the mid-secretory as compared to the early secretory cycle phase. | The differences in RCAS1 and DFF45 endometrial expression between late proliferative, early secretory, and mid-secretory cycle phases.
Popiela TJ, Wicherek L, Radwan M, Sikora J, Banas T, Basta P, Kulczycka M, Grabiec M, Obrzut B, Kalinka J. | 01/21/2010 |
| identified a TATA-less region upstream of the transcription start site as a basal promoter of the ICAD gene. An E-Box motif, which binds transcription factors of the basic helix-loop-helix/leucine zipper family, is responsible for transcriptional activity | Identification and characterization of the human inhibitor of caspase-activated DNase gene promoter.
Omata K, Suzuki R, Masaki T, Miyamura T, Satoh T, Suzuki T., Free PMC Article | 01/21/2010 |
| C-terminal region of each subunit, DFF40 (RLKRK) and DFF45 (KRAR), is essential for nuclear accumulation of the DFF complex. | Sequence elements in both subunits of the DNA fragmentation factor are essential for its nuclear transport.
Neimanis S, Albig W, Doenecke D, Kahle J. | 01/21/2010 |
| Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation. | Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD).
Dahal GR, Karki P, Thapa A, Shahnawaz M, Shin SY, Lee JS, Cho B, Park IS. | 01/21/2010 |
| demonstrate the cellular mechanisms of neuronal cell degeneration induced via c-Jun-N-terminal kinases and caspase-dependent signaling | Melatonin inhibits MPP+-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells.
Chetsawang J, Govitrapong P, Chetsawang B. | 01/21/2010 |
| subunit structures and stoichiometries in human cells before and after induction of apoptosis | Subunit structures and stoichiometries of human DNA fragmentation factor proteins before and after induction of apoptosis.
Widlak P, Lanuszewska J, Cary RB, Garrard WT. | 01/21/2010 |
| apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression | A unique role of the DNA fragmentation factor in maintaining genomic stability.
Yan B, Wang H, Peng Y, Hu Y, Wang H, Zhang X, Chen Q, Bedford JS, Dewhirst MW, Li CY., Free PMC Article | 01/21/2010 |
| Hypoxia-induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes. | Hypoxia-induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes.
Todor A, Sharov VG, Tanhehco EJ, Silverman N, Bernabei A, Sabbah HN. | 01/21/2010 |
| NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity | Solution structure of the DFF-C domain of DFF45/ICAD. A structural basis for the regulation of apoptotic DNA fragmentation.
Fukushima K, Kikuchi J, Koshiba S, Kigawa T, Kuroda Y, Yokoyama S. | 01/21/2010 |
| Hepatitis C virus core protein increases a steady-state level of ICAD protein, possibly through enhancing its promoter activity | Antiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase.
Sacco R, Tsutsumi T, Suzuki R, Otsuka M, Aizaki H, Sakamoto S, Matsuda M, Seki N, Matsuura Y, Miyamura T, Suzuki T. | 01/21/2010 |
| DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma tumors | Analyses of apoptotic regulators CASP9 and DFFA at 1P36.2, reveal rare allele variants in human neuroblastoma tumours.
Abel F, Sjöberg RM, Ejeskär K, Krona C, Martinsson T., Free PMC Article | 01/21/2010 |
| plays an important and P53-independent role in maintaining chromosome stability and suppressing tumor development | Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.
Yan B, Wang H, Wang H, Zhuo D, Li F, Kon T, Dewhirst M, Li CY. | 01/21/2010 |