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    DEFB1 defensin beta 1 [ Homo sapiens (human) ]

    Gene ID: 1672, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Polymorphic variation of the DEFB1 gene might contribute to the development of ankylosing spondylitis: a preliminary study.

    Polymorphic variation of the DEFB1 gene might contribute to the development of ankylosing spondylitis: a preliminary study.
    Fernández-Torres J, Zamudio-Cuevas Y, Martínez-Flores K.

    10/23/2024
    Effects of Schumann resonance on the proliferation and migration of normal human epidermal keratinocytes and the expression of DEFB1 and SIRT1.

    Effects of Schumann resonance on the proliferation and migration of normal human epidermal keratinocytes and the expression of DEFB1 and SIRT1.
    Sugiwaki H, Kotani M, Fujita A, Moriwaki S.

    02/6/2024
    Relationship between biofilm-forming microorganisms (BFM: Staphylococcus aureus and Pseudomonas aeruginosa) and DEFB1 gene variants on beta-defensin levels in periprosthetic joint infection (PJI).

    Relationship between biofilm-forming microorganisms (BFM:  Staphylococcus aureus and Pseudomonas aeruginosa) and DEFB1 gene variants on β-defensin levels in periprosthetic joint infection (PJI).
    Fernández-Torres J, Zamudio-Cuevas Y, Martínez-Flores K, Franco-Cendejas R.

    02/1/2024
    Salivary Th17 cytokine, human beta-defensin 1-3, and salivary scavenger and agglutinin levels in Crohn's disease.

    Salivary Th17 cytokine, human β-defensin 1-3, and salivary scavenger and agglutinin levels in Crohn's disease.
    Gürsoy UK, Gürsoy M, Loimaranta V, Rautava J., Free PMC Article

    01/29/2024
    Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients.

    Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients.
    Farag AGA, Shoeib MAA, Labeeb AZ, Sleem AS, Khallaf HMA, Khalifa AS, Elshaib ME, Elnaidany NF, Hanout HMA., Free PMC Article

    02/27/2023
    Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.

    Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.
    Ma F, He H, Chen S, Yu X, Liu Q, Zeng X., Free PMC Article

    01/11/2023
    beta-defensin 1 Gene Polymorphisms are Associated with Kidney Disease in Northwestern Mexicans with Type 2 Diabetes.

    β-defensin 1 Gene Polymorphisms are Associated with Kidney Disease in Northwestern Mexicans with Type 2 Diabetes.
    Ochoa-Ramirez LA, Rodriguez Millan J, Mendoza Vázquez LF, Díaz-Camacho SP, Verdugo Quiñonez SI, Rojas-Herrera DC, López Castro M, Prado Montes de Oca E, Velarde-Felix JS.

    07/23/2022
    In-silico analysis of non-synonymous single nucleotide polymorphisms in human beta-defensin type 1 gene reveals their impact on protein-ligand binding sites.

    In-silico analysis of non-synonymous single nucleotide polymorphisms in human β-defensin type 1 gene reveals their impact on protein-ligand binding sites.
    Fareed MM, Ullah S, Aziz S, Johnsen TA, Shityakov S.

    06/11/2022
    Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays.

    Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays.
    Jagender Singh JK, Vaithilingam RD, Ng CC, Baharuddin NA, Hasnur Safii S, Rahman MT.

    03/19/2022
    An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children.

    An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children.
    Wu L, Li Z, Zhou J, Ma B, Yu F, Zheng X, Hu X, Ma Z, Su X.

    02/26/2022
    Cervicovaginal levels of human beta defensins during bacterial vaginosis.

    Cervicovaginal levels of human beta defensins during bacterial vaginosis.
    Noda-Nicolau NM, Silva MC, Bento GFC, Ferreira JSB, Novak J, Morales JAP, Tronco JA, Bolpetti AN, Pinto GVS, Polettini J, Marconi C, Silva MGD., Free PMC Article

    01/8/2022
    Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population.

    Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population.
    Almutairi M, Almutairi B, Almutairi M, Parine NR, Alrefaei A, Alanazi M, Semlali A., Free PMC Article

    09/4/2021
    DEFB1 gene polymorphisms modify vitiligo extent and response to NB-UVB phototherapy.

    DEFB1 gene polymorphisms modify vitiligo extent and response to NB-UVB phototherapy.
    Salem RM, Abdelrahman AMN, Abd El-Kareem HM, Seif M.

    07/17/2021
    Regulatory SNP rs5743417 impairs constitutive expression of human beta-defensin 1 and has high frequency in Africans and Afro-Americans.

    Regulatory SNP rs5743417 impairs constitutive expression of human β-defensin 1 and has high frequency in Africans and Afro-Americans.
    Cruz Díaz LA, Gutiérrez Ortega A, Chávez Álvarez RDC, Velarde Félix JS, Prado Montes de Oca E.

    06/12/2021
    Relative quantification of human betadefensins gene expression in pterygium and normal conjunctiva samples.

    Relative quantification of human β‑defensins gene expression in pterygium and normal conjunctiva samples.
    Abubakar SA, Isa MM, Omar N, Tan SW.

    05/15/2021
    Beta-defensin 1 gene polymorphisms in the pathologies of the oral cavity-Data from meta-analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362.

    Beta-defensin 1 gene polymorphisms in the pathologies of the oral cavity-Data from meta-analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362.
    Ślebioda Z, Woźniak T, Dorocka-Bobkowska B, Woźniewicz M, Kowalska A.

    02/27/2021
    Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis.

    Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis.
    Hatipoğlu Ö, Saydam F.

    02/2/2021
    Association of systemic beta-defensin-1 and -20G/A DEFB1 gene polymorphism with Behcet's disease.

    Association of systemic beta-defensin-1 and -20G/A DEFB1 gene polymorphism with Behçet's disease.
    Kallel A, Ben Salem T, Hammami MB, Said F, Jemaa R, Houman MH, Feki M.

    09/19/2020
    Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus.

    Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus.
    Yilmaz D, Topcu AO, Akcay EU, Altındis M, Gursoy UK.

    08/13/2020
    the DEFB1-G1654A polymorphism may be a genetic susceptibility factor for periodontitis

    Association between DEFB1 polymorphisms and periodontitis: a meta-analysis.
    Zhong S, Wang C, Gao R, Shu S, Shu C.

    05/23/2020
    High hBD-1 was detected at presentation in patients with acute-on-chronic liver failure (ACLF) who died during follow-up period. hBD-1 is an accurate predictor of short-term mortality in patients with ACLF.

    Human beta-defensin-1 is a highly predictive marker of mortality in patients with acute-on-chronic liver failure.
    Mani I, Alexopoulou A, Vasilieva L, Hadziyannis E, Agiasotelli D, Bei M, Alexopoulos T, Dourakis SP.

    02/15/2020
    this meta-analysis demonstrated that gene polymorphism of DEFB1 but not of CD14 might be involved in periodontitis risk [meta-analysis]

    Association between Periodontitis and Gene polymorphisms of hBD-1 and CD14: a meta-analysis.
    Chen C, Fan X, Yu S, Liu P, Pan Y, Lin L, Li C.

    01/11/2020
    DEFB1 polymorphisms were significantly associated with decreased risk of HIV-1 infection acquisition in the studied Zambian population suggesting that they may play a role in HIV-1 mother-to-child transmission.

    DEFB1 polymorphisms and HIV-1 mother-to-child transmission in Zambian population.
    Zupin L, Polesello V, Segat L, Kamada AJ, Kuhn L, Crovella S., Free PMC Article

    12/28/2019
    The role of the tested single nucleotide polymorphisms of the beta-defensin 1 gene in the etiology of recurrent aphthous stomatitis has not been confirmed.

    Beta-defensin 1 gene polymorphisms at 5' untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis.
    Kowalska A, Ślebioda Z, Woźniak T, Zasadziński R, Daszkowska M, Dorocka-Bobkowska B.

    12/21/2019
    Role and function of the EGFR-ERK-MYC axis as a repressor of HBD1 expression and suppression observed in colorectal cancer.

    Expression of the human antimicrobial peptide β-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells.
    Bonamy C, Sechet E, Amiot A, Alam A, Mourez M, Fraisse L, Sansonetti PJ, Sperandio B., Free PMC Article

    12/7/2019
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