| Human Intestinal Defensin 5 Ameliorates the Sensitization of Colonic Cancer Cells to 5-Fluorouracil. | Human Intestinal Defensin 5 Ameliorates the Sensitization of Colonic Cancer Cells to 5-Fluorouracil.
Panjeta A, Kaur K, Sharma R, Verma I, Preet S. | 03/11/2024 |
| The Function and Modification of Human Defensin 5. | The Function and Modification of Human Defensin 5.
Chang XY, Zhang MW, Zhang LJ, Chai LQ. | 12/28/2023 |
| Reduced DEFA5 Expression and STAT3 Activation Underlie the Submucosal Invasion of Early Gastric Cancers. | Reduced DEFA5 Expression and STAT3 Activation Underlie the Submucosal Invasion of Early Gastric Cancers.
Nagao S, Takahashi Y, Denda T, Tanaka Y, Miura Y, Mizutani H, Ohki D, Sakaguchi Y, Yakabi S, Tsuji Y, Niimi K, Kakushima N, Yamamichi N, Ota Y, Koike K, Fujishiro M., Free PMC Article | 12/15/2023 |
| Association between alpha-defensin 5 and the expression and function of P-glycoprotein in differentiated intestinal Caco-2 cells. | Association between α-defensin 5 and the expression and function of P-glycoprotein in differentiated intestinal Caco-2 cells.
Yasuda G, Kubota A, Okamoto K, Narumi K, Furugen A, Kato I, Mori A, Saito Y, Satoh T, Takahashi-Suzuki N, Iseki K, Kobayashi M. | 10/5/2023 |
| 3' untranslated region variants in DEFA5 gene associated with susceptibility to IgA nephropathy in the Chinese Han population. | 3' untranslated region variants in DEFA5 gene associated with susceptibility to IgA nephropathy in the Chinese Han population.
Peng H, Fan P, Hong Y, He J, Zeng X, Xu F, Zhao Y, Jin T. | 02/4/2023 |
| Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study. | Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study.
Shimizu Y, Nakamura K, Kikuchi M, Ukawa S, Nakamura K, Okada E, Imae A, Nakagawa T, Yamamura R, Tamakoshi A, Ayabe T., Free PMC Article | 06/11/2022 |
| Human alpha-defensin 5 suppressed colon cancer growth by targeting PI3K pathway. | Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway.
Qiao Q, Bai R, Song W, Gao H, Zhang M, Lu J, Hong M, Zhang X, Sun P, Zhang Q, Zhao P. | 11/27/2021 |
| Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. | Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease.
Rana T, Korolkova OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Hui N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE., Free PMC Article | 08/28/2021 |
| The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1. | The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1.
Wu Z, Ding Z, Cheng B, Cui Z., Free PMC Article | 03/20/2021 |
| An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease. | An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease.
Rashidi A, Herman A, Gomes ALC, Peled JU, Jenq RR, Brereton DG, Staley C, Blazar BR, Weisdorf DJ., Free PMC Article | 02/2/2021 |
| Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy. | Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy.
Feng S, Zhong Z, Fan J, Li X, Shi D, Jiang L., Free PMC Article | 10/31/2020 |
| Here, the authors report that HD5 greatly promoted phagocytosis of Shigella by macrophages by targeting the bacteria to enhance bacterium-to-cell contacts in a structure- and sequence-dependent fashion. | Human Enteric Defensin 5 Promotes Shigella Infection of Macrophages.
Xu D, Liao C, Xiao J, Fang K, Zhang W, Yuan W, Lu W., Free PMC Article | 01/25/2020 |
| DEFA5 rs4415345 and rs4610776 were associated with altered incidence of aGVHD grade II-IV | Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples.
Rashidi A, Shanley R, Yohe SL, Thyagarajan B, Curtsinger J, Anasetti C, Waller EK, Scott BL, Blazar BR, Weisdorf DJ., Free PMC Article | 07/20/2019 |
| this study demonstrates that age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis | Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis.
Haberman Y, Schirmer M, Dexheimer PJ, Karns R, Braun T, Kim MO, Walters TD, Baldassano RN, Noe JD, Rosh J, Markowitz J, Crandall WV, Mack DR, Griffiths AM, Heyman MB, Baker SS, Kellermayer R, Moulton D, Patel AS, Gulati AS, Steiner SJ, LeLeiko N, Otley A, Oliva-Hemker M, Ziring D, Kirschner BS, Keljo DJ, Guthery SL, Cohen SA, Snapper S, Evans J, Dubinsky M, Aronow B, Hyams JS, Kugathasan S, Huttenhower C, Xavier RJ, Denson LA., Free PMC Article | 06/29/2019 |
| In contrast to oxidized peptides, some reduced defensins exhibit increased vulnerability to proteolytic degradation. In this report, we investigated the susceptibility of Paneth-cell-specific human alpha-defensin 5 (HD-5) and -6 (HD-6) to intestinal proteases using natural human duodenal fluid | Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments.
Ehmann D, Wendler J, Koeninger L, Larsen IS, Klag T, Berger J, Marette A, Schaller M, Stange EF, Malek NP, Jensen BAH, Wehkamp J., Free PMC Article | 05/11/2019 |
| Plasma alpha-Defs 1-3 concentrations correlate with the degree of inflammation and appear to be specific biomarkers of ileal-Crohn's disease at diagnosis. Ileal alpha-Def 5 expression is down-regulated permanently by methylation. | Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility.
Cerrillo E, Moret I, Iborra M, Ramos D, Busó E, Tortosa L, Sáez-González E, Nos P, Beltrán B., Free PMC Article | 03/30/2019 |
| The binding mechanisms of HD5 on lipopolysaccharide in comparison to a bare DMPC lipid membrane was studied using molecular dynamics (MD) simulations. | The adsorption of human defensin 5 on bacterial membranes: simulation studies.
Awang T, Pongprayoon P. | 12/22/2018 |
| Bifidobacterium infantis NLS super strain decreases Paneth cell counts and expression of alpha-defensin-5 in celiac disease. | Bifidobacterium infantis NLS Super Strain Reduces the Expression of α-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients.
Pinto-Sánchez MI, Smecuol EC, Temprano MP, Sugai E, González A, Moreno ML, Huang X, Bercik P, Cabanne A, Vázquez H, Niveloni S, Mazure R, Mauriño E, Verdú EF, Bai JC. | 05/26/2018 |
| Human alpha-Defensin-5 is a potential candidate biomarker to molecularly differentiate Crohn's colitis from ulcerative colitis, to our knowledge. These data give us both a potential diagnostic marker in Human alpha-Defensin-5 and insight to develop future mechanistic studies to better understand crypt biology in Crohn's colitis. | Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.
Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE., Free PMC Article | 10/21/2017 |
| Different dynamics and pathway of disulfide bonds reduction has been demonstrated for two human defensins, HD5 and HBD-3. | Different dynamics and pathway of disulfide bonds reduction of two human defensins, a molecular dynamics simulation study.
Zhang L. | 07/29/2017 |
| These data support capsid stabilization and redirection to the lysosome during infection as a general antiviral mechanism of alpha-defensins against nonenveloped viruses. | α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome.
Wiens ME, Smith JG., Free PMC Article | 07/1/2017 |
| Human adenovirus 3 produces large amounts of penton-dodecahedra (PtDd), virus-like particles, during replication, which also function in blocking of HD5. | Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy.
Vragniau C, Hübner JM, Beidler P, Gil S, Saydaminova K, Lu ZZ, Yumul R, Wang H, Richter M, Sova P, Drescher C, Fender P, Lieber A., Free PMC Article | 05/20/2017 |
| no biologic differences between wild-type HD5 and its variants were observed on HD5 antibacterial activity against Escherichia coli | Prediction of the impact of coding missense and nonsense single nucleotide polymorphisms on HD5 and HBD1 antibacterial activity against Escherichia coli.
Porto WF, Nolasco DO, Pires ÁS, Pereira RW, Franco OL, Alencar SA. | 04/8/2017 |
| a moderately active linear peptide derived from the alpha-defensin HD5 can be engineered to enhance antimicrobial activity almost comparable to the native peptide. | Antimicrobial activity of human α-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs.
Mathew B, Nagaraj R. | 06/28/2016 |
| The study used ion mobility coupled to mass spectrometry to track the structural changes in HD-5 upon disulfide bond reduction. | Conformational landscape and pathway of disulfide bond reduction of human alpha defensin.
Snijder J, van de Waterbeemd M, Glover MS, Shi L, Clemmer DE, Heck AJ., Free PMC Article | 01/16/2016 |