| Unveiling the DHX15-G-patch interplay in retroviral RNA packaging. | Unveiling the DHX15-G-patch interplay in retroviral RNA packaging.
Dostálková A, Křížová I, Junková P, Racková J, Kapisheva M, Novotný R, Danda M, Zvonařová K, Šinkovec L, Večerková K, Bednářová L, Ruml T, Rumlová M., Free PMC Article | 10/2/2024 |
| GPATCH4 regulates rRNA and snRNA 2'-O-methylation in both DHX15-dependent and DHX15-independent manners. | GPATCH4 regulates rRNA and snRNA 2'-O-methylation in both DHX15-dependent and DHX15-independent manners.
Kanwal N, Krogh N, Memet I, Lemus-Diaz N, Thomé CC, Welp LM, Mizi A, Hackert P, Papantonis A, Urlaub H, Nielsen H, Bohnsack KE, Bohnsack MT., Free PMC Article | 03/1/2024 |
| Splicing quality control mediated by DHX15 and its G-patch activator SUGP1. | Splicing quality control mediated by DHX15 and its G-patch activator SUGP1.
Feng Q, Krick K, Chu J, Burge CB., Free PMC Article | 11/10/2023 |
| Relationship between DHX15 expression and survival in colorectal cancer. | Relationship between DHX15 expression and survival in colorectal cancer.
Fan L, Guo X, Zhang J, Wang Y, Wang J, Li Y. | 05/31/2023 |
| DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. | DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Zhang J, Huang J, Xu K, Xing P, Huang Y, Liu Z, Tong L, Manley JL., Free PMC Article | 12/17/2022 |
| Prp43/DHX15 exemplify RNA helicase multifunctionality in the gene expression network. | Prp43/DHX15 exemplify RNA helicase multifunctionality in the gene expression network.
Bohnsack KE, Kanwal N, Bohnsack MT., Free PMC Article | 11/19/2022 |
| DHX15 is required to control RNA virus-induced intestinal inflammation. | DHX15 is required to control RNA virus-induced intestinal inflammation.
Xing J, Zhou X, Fang M, Zhang E, Minze LJ, Zhang Z., Free PMC Article | 02/12/2022 |
| Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway. | Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway.
Cai Y, Wang J, Jin D, Liu Q, Chen X, Pan L, Li Y, Wang X, Qian F, Wang J, Zhong TP, Wang S., Free PMC Article | 09/18/2021 |
| RNA affinity, helicase, and ATPase activity of DHX15 are increased when the G-patch motif of NKRF binds in an extended conformation across the helicase surface | Structural basis for DEAH-helicase activation by G-patch proteins.
Studer MK, Ivanović L, Weber ME, Marti S, Jonas S., Free PMC Article | 07/18/2020 |
| The DHX15 selectively binds PAMP RNA to promote RIG-I ATP hydrolysis and signaling activation in response to viral RNA. The results define DHX15 as a coreceptor required for RLR innate immune responses to control RNA virus infection. | DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection.
Pattabhi S, Knoll ML, Gale M , Jr, Loo YM., Free PMC Article | 06/6/2020 |
| these findings demonstrate, for the first time, that DHX15 is significantly upregulated in hepatocellular carcinoma and its high expression was correlated with poor prognosis, suggesting its pivotal role in the progression of hepatocellular carcinoma | Overexpression and clinical relevance of the RNA helicase DHX15 in hepatocellular carcinoma.
Xie C, Liao H, Zhang C, Zhang S. | 11/16/2019 |
| ETS1 and SP1 regulated DHX15 expression in acute lymphoblastic leukaemia. | ETS1 and SP1 drive DHX15 expression in acute lymphoblastic leukaemia.
Chen XL, Cai YH, Liu Q, Pan LL, Shi SL, Liu XL, Chen Y, Li JG, Wang J, Li Y, Li XF, Wang SY., Free PMC Article | 10/26/2019 |
| CMTr1 binds ATP-dependent RNA DHX15 helicase and that this interaction, mediated by the G-patch domain of CMTr1, has an advantageous effect on CMTr1 activity towards highly structured RNA substrates. | Human RNA cap1 methyltransferase CMTr1 cooperates with RNA helicase DHX15 to modify RNAs with highly structured 5' termini.
Toczydlowska-Socha D, Zielinska MM, Kurkowska M, Astha, Almeida CF, Stefaniak F, Purta E, Bujnicki JM., Free PMC Article | 08/31/2019 |
| DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression. | DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor.
Jing Y, Nguyen MM, Wang D, Pascal LE, Guo W, Xu Y, Ai J, Deng FM, Masoodi KZ, Yu X, Zhang J, Nelson JB, Xia S, Wang Z., Free PMC Article | 10/13/2018 |
| The crystal structure of human DHX15 reveals a domain organization of the mammalian DEAH/RHA family. | The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.
Murakami K, Nakano K, Shimizu T, Ohto U., Free PMC Article | 12/9/2017 |
| Loss of DHX15 expression is associated with glioma. | RNA helicase DHX15 acts as a tumour suppressor in glioma.
Ito S, Koso H, Sakamoto K, Watanabe S., Free PMC Article | 11/11/2017 |
| depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. | The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.
Memet I, Doebele C, Sloan KE, Bohnsack MT., Free PMC Article | 09/23/2017 |
| Mutation in DHX15 is associated with core-binding factor acute myeloid leukemia. | The genomic landscape of core-binding factor acute myeloid leukemias.
Faber ZJ, Chen X, Gedman AL, Boggs K, Cheng J, Ma J, Radtke I, Chao JR, Walsh MP, Song G, Andersson AK, Dang J, Dong L, Liu Y, Huether R, Cai Z, Mulder H, Wu G, Edmonson M, Rusch M, Qu C, Li Y, Vadodaria B, Wang J, Hedlund E, Cao X, Yergeau D, Nakitandwe J, Pounds SB, Shurtleff S, Fulton RS, Fulton LL, Easton J, Parganas E, Pui CH, Rubnitz JE, Ding L, Mardis ER, Wilson RK, Gruber TA, Mullighan CG, Schlenk RF, Paschka P, Döhner K, Döhner H, Bullinger L, Zhang J, Klco JM, Downing JR., Free PMC Article | 09/9/2017 |
| Data indicate that DEAH-box RNA helicase DHX15/PRP43 stimulates the NF-kappaB and MAPK pathways downstream of virus-induced signaling adapter protein MAVS and contributes to MAVS-mediated cytokine production and apoptosis. | The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.
Mosallanejad K, Sekine Y, Ishikura-Kinoshita S, Kumagai K, Nagano T, Matsuzawa A, Takeda K, Naguro I, Ichijo H. | 02/21/2015 |
| The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. | The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis.
Chen YL, Capeyrou R, Humbert O, Mouffok S, Kadri YA, Lebaron S, Henras AK, Henry Y., Free PMC Article | 08/23/2014 |
| Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. | Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity.
Niu Z, Jin W, Zhang L, Li X. | 06/2/2012 |