| Furthermore, Ly49/MHC-I interactions are diffusion-controlled and enthalpy-driven. | Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules.
Romasanta PN, Curto LM, Sarratea MB, Noli Truant S, Antonoglou MB, Fernández Lynch MJ, Delfino JM, Mariuzza RA, Fernández MM, Malchiodi EL. | 06/10/2017 |
| Ly49H has a role in antiviral activity. | Targeting of a natural killer cell receptor family by a viral immunoevasin.
Berry R, Ng N, Saunders PM, Vivian JP, Lin J, Deuss FA, Corbett AJ, Forbes CA, Widjaja JM, Sullivan LC, McAlister AD, Perugini MA, Call MJ, Scalzo AA, Degli-Esposti MA, Coudert JD, Beddoe T, Brooks AG, Rossjohn J. | 11/16/2013 |
| Signaling through the Ly49H receptor is necessary to induce transient Ly49H-mediated natural killer (NK) cell tolerance during chronic viral infection. | Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible.
Bolanos FD, Tripathy SK., Free PMC Article | 05/21/2011 |
| m157 gene(G1F)-Ly49C interactions cause no apparent attenuating effect on clearance of murine cytomegalovirus from natural killer (NK) cells. | Functional consequences of natural sequence variation of murine cytomegalovirus m157 for Ly49 receptor specificity and NK cell activation.
Corbett AJ, Coudert JD, Forbes CA, Scalzo AA. | 03/12/2011 |
| Ly49H-regulated NK-cell control of murine CMV infection is dependent on pfp-mediated cytolysis. | The roles of interferon-gamma and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activity.
Sumaria N, van Dommelen SL, Andoniou CE, Smyth MJ, Scalzo AA, Degli-Esposti MA. | 01/21/2010 |
| NK cell expansion is increased through an Ly49H-dependent pathway to promote alternative beneficial effects. | Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection.
Lee SH, Kim KS, Fodil-Cornu N, Vidal SM, Biron CA., Free PMC Article | 01/21/2010 |
| Optimal natural killer cell-mediated immunity to cytomegalovirus depends on Ly49H signaling through DAP10 and DAP12. | Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.
Orr MT, Sun JC, Hesslein DG, Arase H, Phillips JH, Takai T, Lanier LL., Free PMC Article | 01/21/2010 |
| these data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells. | DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
Tassi I, Le Friec G, Gilfillan S, Takai T, Yokoyama WM, Colonna M., Free PMC Article | 01/21/2010 |
| Ly49H-positive natural killer (NK) cells contain a systemic production of cytokines that may contribute to murine cytomegalovirus-induced pathology and play a central role in maintaining normal spleen cell microarchitecture. | Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.
Fodil-Cornu N, Lee SH, Belanger S, Makrigiannis AP, Biron CA, Buller RM, Vidal SM., Free PMC Article | 01/21/2010 |
| Ly49h is necessary for genetic resistance to murine cytomegalovirus. | Ly49h is necessary for genetic resistance to murine cytomegalovirus.
Cheng TP, French AR, Plougastel BF, Pingel JT, Orihuela MM, Buller ML, Yokoyama WM., Free PMC Article | 01/21/2010 |
| transgenic mice were more susceptible to MCMV infection and were unable to reject m157-Tg bone marrow, suggesting defects in Ly49H(+) NK cells | Continuous engagement of a self-specific activation receptor induces NK cell tolerance.
Tripathy SK, Keyel PA, Yang L, Pingel JT, Cheng TP, Schneeberger A, Yokoyama WM., Free PMC Article | 01/21/2010 |
| m157 mutations are predicted to alter the conformation of a putative m157 interface with Ly49H, one that relies on the position of a critical alpha0 helix of m157 | Characterization of murine cytomegalovirus m157 from infected cells and identification of critical residues mediating recognition by the NK cell receptor Ly49H.
Davis AH, Guseva NV, Ball BL, Heusel JW., Free PMC Article | 01/21/2010 |
| In mouse cytomegalovirus(MCMV)-resistant mice, the viral m157 protein engages a related activating receptor (Ly49H) and confers host protection | Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.
Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL. | 01/21/2010 |
| Natural killer cells in New Zealand White mice apparently use a Cmv1-independent mechanism controlled through multiple genes to limit murine cytomegalovirus infection. | Cmv1-independent antiviral role of NK cells revealed in murine cytomegalovirus-infected New Zealand White mice.
Rodriguez M, Sabastian P, Clark P, Brown MG. | 01/21/2010 |
| Genetic control of innate immune responses against cytomegalovirus can be attributed to a single genetic locus termed Cmv1. | Genetic control of innate immune responses against cytomegalovirus: MCMV meets its match.
Webb JR, Lee SH, Vidal SM. | 01/21/2010 |