| Most of the natural killer cell p46-related protein (NKp46) and NK cell Lectin-like receptor subfamily A (Ly49A) molecules were restricted to microdomains; however, individual NKp46 molecules resided in these domains for shorter periods and diffused faster on the surface of educated, compared to hyporesponsive, NK cells. | Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A.
Staaf E, Hedde PN, Bagawath Singh S, Piguet J, Gratton E, Johansson S., Free PMC Article | 09/21/2019 |
| study found the receptor Ly49A bound the MHC class I molecule H2-M3 with an affinity similar to its affinity for H-2D(d); specific recognition of H2-M3 by Ly49A regulated 'licensing' of NK cells and mediated 'missing-self' recognition of H2-M3-deficient bone marrow | Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.
Andrews DM, Sullivan LC, Baschuk N, Chan CJ, Berry R, Cotterell CL, Lin J, Halse H, Watt SV, Poursine-Laurent J, Wang CR, Scalzo AA, Yokoyama WM, Rossjohn J, Brooks AG, Smyth MJ., Free PMC Article | 01/26/2013 |
| The difference in frequency of Ly49A-specific natural killer (NK) cells between H2-Dd+/+ and H2-Dd+/2 mice is reflected by a skewed balance between proliferation and apoptosis in this subset. | Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.
Brodin P, Lakshmikanth T, Kärre K, Höglund P. | 06/12/2012 |
| Overexpression of Ly49A enhanced the tumor killing activity of mouse lymphocytes. | [In vitro study of the killing activities on H-2(d) murine normal and tumor cells by Ly49A gene transfected lymphocytes].
Li Y, Guo K, Chen H, Li J, Wang F, Xie K, Wei Y, Huang J, Ren D. | 05/31/2010 |
| The membrane proximal nonligand binding ecto-domain (the stalk region) of Ly49A is critical to ligand binding and signaling. | Essential role of the Ly49A stalk region for immunological synapse formation and signaling.
Ito D, Iizuka YM, Katepalli MP, Iizuka K., Free PMC Article | 01/21/2010 |
| Ly49A blocks Zap70, extracellular signal-regulated kinase 1/2 and c-Jun activation but leaves unique components of the CD28 signaling pathway intact. | Engagement of transgenic Ly49A inhibits mouse CD4 cell activation by disrupting T cell receptor, but not CD28, signaling.
Leavenworth JW, Pauza ME. | 01/21/2010 |
| The association with MHC-I in cis sequestered wild-type Ly49A, and this was found to relieve NK cells from a suppressive effect of unengaged Ly49A | A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.
Chalifour A, Scarpellino L, Back J, Brodin P, Devèvre E, Gros F, Lévy F, Leclercq G, Höglund P, Beermann F, Held W. | 01/21/2010 |
| DNA methylation and the histone acetylation state of the Pro-2 promoter region of Ly49a are strictly linked with Ly49a expression status. | Evidence for epigenetic maintenance of Ly49a monoallelic gene expression.
Rouhi A, Gagnier L, Takei F, Mager DL. | 01/21/2010 |
| the NK cells' own MHC-I significantly masks the Ly49A and Ly49C, but not the Ly49I receptor | Interactions of Ly49 family receptors with MHC class I ligands in trans and cis.
Scarpellino L, Oeschger F, Guillaume P, Coudert JD, Lévy F, Leclercq G, Held W. | 01/21/2010 |
| H-2Dd cis ligand has a role in Ly49A localization to the site of NK cell/target cell contact | Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.
Back J, Chalifour A, Scarpellino L, Held W., Free PMC Article | 01/21/2010 |
| Ly49A engagement on T cells dramatically limits T-cell activation and the resultant lymphoproliferative disorder that occurs in CTLA-4-deficient mice. | The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor.
Chambers CA, Kang J, Wu Y, Held W, Raulet DH, Allison JP. | 01/21/2010 |
| The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment. | A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
Lowin-Kropf B, Kunz B, Schneider P, Held W. | 01/21/2010 |
| The role of an exposed loop in the alpha2 domain in the mouse MHC class I H-2Dd molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A. | The role of an exposed loop in the alpha2 domain in the mouse MHC class I H-2Dd molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A.
Waldenström M, Achour A, Michaelsson J, Rölle A, Kärre K. | 01/21/2010 |
| X-ray structure of Ly49A (Klra1 encoded NK receptor) in complex with MHC-I ligand, H-2Dd. | Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand.
Tormo J, Natarajan K, Margulies DH, Mariuzza RA. | 03/7/2003 |