| Voltage-dependent potassium channel Kv4.2 alleviates the ischemic stroke impairments through activating neurogenesis. | Voltage-dependent potassium channel Kv4.2 alleviates the ischemic stroke impairments through activating neurogenesis.
Xiao F, Zhang X, Ni P, Yu H, Gao Q, Li M, Huo P, Wei Z, Wang S, Zhang Y, Zhao R, Li A, Li Z, Li Y, Cheng H, Du L, Ren S, Yu Q, Liu Y, Zhao Y. | 02/26/2022 |
| The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice. | The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.
Tiwari D, Schaefer TL, Schroeder-Carter LM, Krzeski JC, Bunk AT, Parkins EV, Snider A, Danzer R, Williams MT, Vorhees CV, Danzer SC, Gross C., Free PMC Article | 03/13/2021 |
| Study uncovers increased levels of active GSK3beta in the nucleus accumbens (NAc) of mice with a depressive-like phenotype induced by chronic stress. Increased levels of active GSK3beta within the NAc of these mice lead to altered synaptic plasticity in medium spiny neurons through phosphorylation of the Kv4.2 subunit uncovering molecular mechanism of underlying depression-like behaviors. | Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels.
Aceto G, Colussi C, Leone L, Fusco S, Rinaudo M, Scala F, Green TA, Laezza F, D'Ascenzo M, Grassi C., Free PMC Article | 07/25/2020 |
| activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr(607)-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex. | Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility.
Hu JH, Malloy C, Tabor GT, Gutzmann JJ, Liu Y, Abebe D, Karlsson RM, Durell S, Cameron HA, Hoffman DA., Free PMC Article | 07/18/2020 |
| Results identify the functional interaction between GSK3beta and Kv4.2 channel as a novel mechanism for long-term depression modulation providing exciting insight into the understanding of GSK3beta role in synaptic plasticity. | GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels.
Aceto G, Re A, Mattera A, Leone L, Colussi C, Rinaudo M, Scala F, Gironi K, Barbati SA, Fusco S, Green T, Laezza F, D'Ascenzo M, Grassi C., Free PMC Article | 07/18/2020 |
| Kv4 interacting dynamically with persistent sodium currents is a key determinant of the irregular firing behaviour of Kiss1(Arc) neurons. | Kv4.2 channel activity controls intrinsic firing dynamics of arcuate kisspeptin neurons.
Mendonça PRF, Kyle V, Yeo SH, Colledge WH, Robinson HPC., Free PMC Article | 08/24/2019 |
| we are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting. | Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes.
Vysotskaya Z, Chidipi B, Rodgers JL, Tang X, Samal E, Kolliputi N, Mohapatra S, Bennett ES, Panguluri SK. | 02/23/2019 |
| The results reveal an important role for miR-324-5p-mediated silencing of Kv4.2 in seizure onset. | MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset.
Gross C, Yao X, Engel T, Tiwari D, Xing L, Rowley S, Danielson SW, Thomas KT, Jimenez-Mateos EM, Schroeder LM, Pun RYK, Danzer SC, Henshall DC, Bassell GJ., Free PMC Article | 11/18/2017 |
| Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. | Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.
Yao JJ, Zhao QR, Liu DD, Chow CW, Mei YA., Free PMC Article | 05/7/2017 |
| Result suggests that the memory type supported by neurons may depend critically on the phosphorylation of specific K+ channels at single residues. | Phosphorylation of K+ channels at single residues regulates memory formation.
Vernon J, Irvine EE, Peters M, Jeyabalan J, Giese KP., Free PMC Article | 12/17/2016 |
| Data show that suprachiasmatic nucleus (SCN) explants from potassium channel Kv1.4(-/-)period2 protein Per2(Luc) and potassium channel Kv4.2(-/-) period2 protein Per2(Luc) mice have significantly shorter circadian periods in PER2 rhythms. | IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.
Granados-Fuentes D, Hermanstyne TO, Carrasquillo Y, Nerbonne JM, Herzog ED., Free PMC Article | 06/28/2016 |
| Data show that potassium channel Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-). | Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.
Liu J, Kim KH, Morales MJ, Heximer SP, Hui CC, Backx PH., Free PMC Article | 05/7/2016 |
| This study demonstrated that Dendritic hyperexcitability induced by Kv4.2 deficiency exacerbated behavioral deficits and increased epileptiform activity amyloid protein precursor mutation mice. | Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease.
Hall AM, Throesch BT, Buckingham SC, Markwardt SJ, Peng Y, Wang Q, Hoffman DA, Roberson ED., Free PMC Article | 06/20/2015 |
| Real-time RT-PCR and Western blotting revealed that Kv4.2 expression was downregulated in both BSO-treated groups, whereas KChIP2 expression was downregulated only in the H/M-Sod2(+/-)+BSO group (P<0.05). | Cardiomyocyte-derived mitochondrial superoxide causes myocardial electrical remodeling by downregulating potassium channels and related molecules.
Kurokawa S, Niwano S, Niwano H, Murakami M, Ishikawa S, Masaki Y, Tamaki H, Toda T, Noda Y, Shimizu T, Izumi T, Ako J. | 04/4/2015 |
| WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude | The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D., Free PMC Article | 02/22/2014 |
| MiR-301a may be a central regulator for the expression of Kv4.2 in diabetes. | MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators.
Panguluri SK, Tur J, Chapalamadugu KC, Katnik C, Cuevas J, Tipparaju SM., Free PMC Article | 10/26/2013 |
| The experiments here demonstrate that Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons. | A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.
Carrasquillo Y, Burkhalter A, Nerbonne JM., Free PMC Article | 01/12/2013 |
| Kv4.2 regulation of excitability determines synaptic maturation site in CA1 hippocampal pyramidal neurons. | Dynamic regulation of synaptic maturation state by voltage-gated A-type K+ channels in CA1 hippocampal pyramidal neurons.
Kim E, Hoffman DA., Free PMC Article | 01/5/2013 |
| Kv1.4- and Kv4.2-encoded I(A) channels regulate the intrinsic excitability of SCN neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN neuron firing and locomotor behavior. | I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.
Granados-Fuentes D, Norris AJ, Carrasquillo Y, Nerbonne JM, Herzog ED., Free PMC Article | 10/27/2012 |
| The combined down-regulation of Kv4.2, Kv1.5 and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model. | Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.
Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, Nishizawa H, Chugun A, Sakurai T, Daida H, Morimoto S, Kurebayashi N., Free PMC Article | 09/1/2012 |
| our findings suggest an important role for Kv4.2 channels in hippocampal-dependent learning and memory | Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits.
Lugo JN, Brewster AL, Spencer CM, Anderson AE., Free PMC Article | 08/18/2012 |
| The results presented here identify Navbeta1 as a component of native neuronal Kv4.2-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability. | The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.
Marionneau C, Carrasquillo Y, Norris AJ, Townsend RR, Isom LL, Link AJ, Nerbonne JM., Free PMC Article | 06/30/2012 |
| In the presence of DPP6 or DPP10, cell surface Kv4.2 protein expression is selectively increased. | Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.
Foeger NC, Norris AJ, Wren LM, Nerbonne JM., Free PMC Article | 06/16/2012 |
| For the other type of synaptic plasticity, long-term depression, the threshold was significantly increased in Kv4.2-/- mice | Dendritic mechanisms controlling the threshold and timing requirement of synaptic plasticity.
Zhao C, Wang L, Netoff T, Yuan LL. | 04/7/2012 |
| we tested Kv4.2 knockout mice in the Morris water maze to assess their spatial reference acquisition and recall abilities | Spatial learning deficits in mice lacking A-type K(+) channel subunits.
Lockridge A, Yuan LL. | 02/11/2012 |