Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K(+) channels. | Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K(+) channels. Stevens SR, Longley CM, Ogawa Y, Teliska LH, Arumanayagam AS, Nair S, Oses-Prieto JA, Burlingame AL, Cykowski MD, Xue M, Rasband MN., Free PMC Article | 10/9/2021 |
Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation. | Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation. Yasuda T, Cuny H, Adams DJ., Free PMC Article | 12/7/2013 |
The resting (closed) Kv3.1 channel conformation forms the high-affinity state for gambierol. | The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ., Free PMC Article | 11/23/2013 |
high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail. | Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels. Barry J, Xu M, Gu Y, Dangel AW, Jukkola P, Shrestha C, Gu C., Free PMC Article | 11/2/2013 |
Although all Kv3 transcripts were significantly expressed at embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 subunit proteins were present, suggesting a novel role for Kv3 channels at this developmental stage. | Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. Boda E, Hoxha E, Pini A, Montarolo F, Tempia F. | 03/2/2013 |
Block of Kv3.1 channels hinders spike repolarization and severely depresses evoked fast firing in deep cerebellar nuclear neurons. | BK and Kv3.1 potassium channels control different aspects of deep cerebellar nuclear neurons action potentials and spiking activity. Pedroarena CM. | 08/18/2012 |
Mice lacking both Kcnc1 and Kcnc2 genes fail to express the Kv3.1 and Kv3.2 channels in in the suprachiasmatic nucleus. | Fast delayed rectifier potassium current: critical for input and output of the circadian system. Kudo T, Loh DH, Kuljis D, Constance C, Colwell CS., Free PMC Article | 06/25/2011 |
These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels. | Sound stimulation modulates high-threshold K(+) currents in mouse auditory brainstem neurons. Leão KE, Leão RN, Deardorff AS, Garrett A, Fyffe R, Walmsley B., Free PMC Article | 03/5/2011 |
As Kcnc1, but not Kcnc3, alleles are lost, mutant mice exhibit increasing gait ataxia accompanied by spike broadening and deceleration in deep cerebellar nuclei. neurons. | Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1. Hurlock EC, Bose M, Pierce G, Joho RH., Free PMC Article | 02/1/2010 |
Kv3.1 expressed in both GAD- and GAD+ cells, albeit at different densities and distribution. They likely contribute to the distinct biophysical properties of both GAD- and GAD+ neurons in the dentate nucleus. | Subcellular localization of the voltage-gated potassium channels Kv3.1b and Kv3.3 in the cerebellar dentate nucleus of glutamic acid decarboxylase 67-green fluorescent protein transgenic mice. Alonso-Espinaco V, Elezgarai I, Díez-García J, Puente N, Knöpfel T, Grandes P. | 01/21/2010 |
results support the hypothesis that altered electrophysiological properties of TRN neurons contribute to the reduced EEG power at slow frequencies in the thalamocortical network of Kv3-deficient mice. | Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo. Espinosa F, Torres-Vega MA, Marks GA, Joho RH., Free PMC Article | 01/21/2010 |
K(V)3.1 K(+) current accounts for significant component of total K(+) current in oligodendrocyte lineage and, in association with OSP/claudin-11, plays significant role in OPC proliferation and migration and myelination of axons. | K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development. Tiwari-Woodruff S, Beltran-Parrazal L, Charles A, Keck T, Vu T, Bronstein J. | 01/21/2010 |
Starburst amacrine cells have large outward currents which are mediated in part by the Kv3.1 channel. | A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina. Ozaita A, Petit-Jacques J, Völgyi B, Ho CS, Joho RH, Bloomfield SA, Rudy B., Free PMC Article | 01/21/2010 |
Motor deficits and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in Kv3.1 knockout mice. | Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in mice lacking potassium channels Kv3.1 and Kv3.3. Matsukawa H, Wolf AM, Matsushita S, Joho RH, Knöpfel T., Free PMC Article | 01/21/2010 |
two voltage-gated potassium channels, Kv3.1 and Kv3.3, control sleep in wild-type and Kv3-mutant mice | Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms. Joho RH, Marks GA, Espinosa F. | 01/21/2010 |
NCS-1 is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium. | Modulation of Kv4-encoded K(+) currents in the mammalian myocardium by neuronal calcium sensor-1. Guo W, Malin SA, Johns DC, Jeromin A, Nerbonne JM. | 01/21/2010 |
interaction with CALP/KCHIP4 | Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. | 01/21/2010 |
Kv4.3, in association with K(+) channel-interacting proteins, is the major molecular determinant of A-type potassium current in murine colonic myocytes. | Contribution of Kv4 channels toward the A-type potassium current in murine colonic myocytes. Amberg GC, Koh SD, Hatton WJ, Murray KJ, Monaghan K, Horowitz B, Sanders KM., Free PMC Article | 01/21/2010 |
Double mutant Kv3.1/Kv3.3-deficient mice are constitutively hyperactive. Increased ambulatory and stereotypic activity in conjunction with sleep loss was seen in Kv3.1-single mutants but not in Kv3.3-single mutants. | Increased motor drive and sleep loss in mice lacking Kv3-type potassium channels. Espinosa F, Marks G, Heintz N, Joho RH. | 01/21/2010 |
Calcineurin and NFATc3 constitute a Ca(2+)-driven signaling module that contributes to the nonuniform distribution of Kv4 expression, and hence Ito function, in the mouse left ventricle. | Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart. Rossow CF, Dilly KW, Santana LF. | 01/21/2010 |
all Renshaw cells expressed Kv3.1b weakly from postnatal day 14, and strongly at postnatal day 21. | Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells. Song ZM, Hu J, Rudy B, Redman SJ. | 01/21/2010 |
Ongoing activity in auditory brainstem neurons is necessary for the maintenance of Kv3.1 tonotopicity through the CREB pathway | Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice. von Hehn CA, Bhattacharjee A, Kaczmarek LK., Free PMC Article | 01/21/2010 |
Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. | Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. Macica CM, von Hehn CA, Wang LY, Ho CS, Yokoyama S, Joho RH, Kaczmarek LK., Free PMC Article | 01/21/2010 |