| Knockout of integrin alphavbeta6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages. | Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages.
Zhu C, Zheng R, Han X, Tang Z, Li F, Hu X, Lin R, Shen J, Pei Q, Wang R, Wei G, Peng Z, Chen W, Liang Z, Zhou Y., Free PMC Article | 06/14/2024 |
| Integrin alphavbeta3 Limits Cytokine Production by Plasmacytoid Dendritic Cells and Restricts TLR-Driven Autoimmunity. | Integrin αvβ3 Limits Cytokine Production by Plasmacytoid Dendritic Cells and Restricts TLR-Driven Autoimmunity.
Lorant AK, Yoshida AE, Gilbertson EA, Chu T, Stefani C, Acharya M, Hamerman JA, Lacy-Hulbert A., | 05/28/2024 |
| Integrin alphaV mediated activation of myofibroblast via mechanoparacrine of transforming growth factor beta1 in promoting fibrous scar formation after myocardial infarction. | Integrin αV mediated activation of myofibroblast via mechanoparacrine of transforming growth factor β1 in promoting fibrous scar formation after myocardial infarction.
Chen YW, Cheng PP, Yin YF, Cai H, Chen JZ, Feng MH, Guo W, Zhao P, Zhang C, Shan XL, Chen HH, Guo S, Lu Y, Xu M. | 01/11/2024 |
| Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression. | Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression.
Zhong L, Zhao J, Huang L, Liu Y, Pang X, Zhan K, Li S, Xue Q, Pan X, Deng L., Free PMC Article | 07/7/2023 |
| Milk osteopontin promotes intestinal development by up-regulating the expression of integrin alphavbeta3 and CD44. | Milk osteopontin promotes intestinal development by up-regulating the expression of integrin αvβ3 and CD44.
Jiang R, Lo J, Prell C, Lönnerdal B. | 05/28/2023 |
| Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin alphaV/beta5 in Parkinson's Disease. | Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease.
Tang C, Liu M, Zhou Z, Li H, Yang C, Yang L, Xiang J., Free PMC Article | 05/19/2023 |
| alphaVbeta3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells. | αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells.
Reis VPD, Keller M, Schmidt K, Ulrich RG, Groschup MH., Free PMC Article | 02/19/2022 |
| Integrin alphavbeta8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. | Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D., Free PMC Article | 02/12/2022 |
| Regulatory T cells promote cancer immune-escape through integrin alphavbeta8-mediated TGF-beta activation. | Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Lainé A, Labiad O, Hernandez-Vargas H, This S, Sanlaville A, Léon S, Dalle S, Sheppard D, Travis MA, Paidassi H, Marie JC., Free PMC Article | 01/1/2022 |
| Autoregulation of insulin receptor signaling through MFGE8 and the alphavbeta5 integrin. | Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
Datta R, Lizama CO, Soltani AK, Mckleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K., Free PMC Article | 12/4/2021 |
| alphaV Integrin Expression and Localization in Male Germ Cells. | αV Integrin Expression and Localization in Male Germ Cells.
Palenikova V, Frolikova M, Valaskova E, Postlerova P, Komrskova K., Free PMC Article | 10/23/2021 |
| Discovery of a new class of integrin antibodies for fibrosis. | Discovery of a new class of integrin antibodies for fibrosis.
Zhang J, Wang T, Saigal A, Johnson J, Morrisson J, Tabrizifard S, Hollingsworth SA, Eddins MJ, Mao W, O'Neill K, Garcia-Calvo M, Carballo-Jane E, Liu D, Ham T, Zhou Q, Dong W, Meng HW, Hicks J, Cai TQ, Akiyama T, Pinto S, Cheng AC, Greshock T, Marquis JC, Ren Z, Talukdar S, Shaheen HH, Handa M., Free PMC Article | 09/25/2021 |
| The Periostin/Integrin-alphav Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver. | The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.
Biswas A, Roy IM, Babu PC, Manesia J, Schouteden S, Vijayakurup V, Anto RJ, Huelsken J, Lacy-Hulbert A, Verfaillie CM, Khurana S., Free PMC Article | 06/5/2021 |
| Differential expression of alphaVbeta3 and alphaVbeta6 integrins in prostate cancer progression. | Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression.
Quaglia F, Krishn SR, Wang Y, Goodrich DW, McCue P, Kossenkov AV, Mandigo AC, Knudsen KE, Weinreb PH, Corey E, Kelly WK, Languino LR., Free PMC Article | 05/15/2021 |
| Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex. | Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex.
Wang P, Ye Y., Free PMC Article | 01/16/2021 |
| Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin alphav and TGF-beta activation. | Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation.
Zhang A, Paidassi H, Lacy-Hulbert A, Savill J., Free PMC Article | 09/12/2020 |
| the decline of estradiol and progesterone downregulates the expression of alphav and beta3 integrins which were influenced by chlorpyrifos exposure | Chlorpyrifos effects on integrin alpha v and beta 3 in implantation window phase.
Gheibi P, Eftekhari Z, Doroud D, Parivar K. | 08/1/2020 |
| These data identify novel roles for alphaVbeta8 and TGFbeta signaling in coordinating microgliogenesis with brain development and implicate abnormally programmed microglia or their products in human neurodevelopmental disorders that share this neuropathology. | Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction.
Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D., Free PMC Article | 05/9/2020 |
| Study demonstrated that pathophysiologically relevant augmentation of alphavbeta3 integrin engagement through loss of Thy-1 surface expression leads to enhanced fibroblast activation, strain stiffening of provisional extracellular matrix, and progression of fibrosis in an in vivo mouse model of lung fibrosis, which would otherwise resolve. | αvβ3 Integrin drives fibroblast contraction and strain stiffening of soft provisional matrix during progressive fibrosis.
Fiore VF, Wong SS, Tran C, Tan C, Xu W, Sulchek T, White ES, Hagood JS, Barker TH., Free PMC Article | 01/11/2020 |
| identified a mechanism of regulation of germinal center (GC) B cell TLR signaling, mediated by alphav integrins and noncanonical autophagy. B cell-specific alphav-KO mice show that loss of alphav-mediated TLR regulation increased GC B cell expansion, somatic hypermutation, class switching, and generation of long-lived plasma cells after immunization with virus-like particles (VLPs) or antigens associated with TLR ligan... | αv Integrins regulate germinal center B cell responses through noncanonical autophagy.
Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, Stuart LM, Orr MT, Rawlings DJ, Jackson SW, Lacy-Hulbert A, Acharya M., Free PMC Article | 09/28/2019 |
| The results of this study indicated that alphavbeta5 integrin, as the very receptor of Vitronectin, is responsible for the progress of the initial differentiation stage in mouse cerebellar granule cellss | αvβ5 integrin mediates the effect of vitronectin on the initial stage of differentiation in mouse cerebellar granule cell precursors.
Abe A, Hashimoto K, Akiyama A, Iida M, Ikeda N, Hamano A, Watanabe R, Hayashi Y, Miyamoto Y. | 05/11/2019 |
| alphav deficiency did not impact on the capacity of Treg to suppress proliferation of naive conventional T cells in vitro as well as in vivo | A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation.
Mair I, Zandee SEJ, Toor IS, Saul L, McPherson RC, Leech MD, Smyth DJ, O'Connor RA, Henderson NC, Anderton SM., Free PMC Article | 03/23/2019 |
| Mice in which alphav integrin is depleted in PDGFRbeta(+) cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis | αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.
Murray IR, Gonzalez ZN, Baily J, Dobie R, Wallace RJ, Mackinnon AC, Smith JR, Greenhalgh SN, Thompson AI, Conroy KP, Griggs DW, Ruminski PG, Gray GA, Singh M, Campbell MA, Kendall TJ, Dai J, Li Y, Iredale JP, Simpson H, Huard J, Péault B, Henderson NC., Free PMC Article | 09/29/2018 |
| Unaffected by Postn, Vav-Itgav(-/-) haematopoietic stem cell proliferate faster in vitro, illustrating the importance of Postn-Itgav interaction. | Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis.
Khurana S, Schouteden S, Manesia JK, Santamaria-Martínez A, Huelsken J, Lacy-Hulbert A, Verfaillie CM., Free PMC Article | 09/8/2018 |
| These results demonstrate that OPN expressed by fatigue-resistant/slow motor neurons is involved in the second-wave neurodegeneration by up-regulating MMP-9 through alphavbeta3 integrin in the mouse model of amyotrophic lateral sclerosis. | Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.
Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H., Free PMC Article | 04/28/2018 |