| The protective roles of integrin alpha4beta7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis. | The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis.
Ryu S, Kim KA, Kim J, Lee DH, Bae YS, Lee H, Kim BC, Kim HY., Free PMC Article | 07/2/2024 |
| Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis. | Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis.
Parte S, Kaur AB, Nimmakayala RK, Ogunleye AO, Chirravuri R, Vengoji R, Leon F, Nallasamy P, Rauth S, Alsafwani ZW, Lele S, Cox JL, Bhat I, Singh S, Batra SK, Ponnusamy MP. | 05/10/2024 |
| LRP12 is an endogenous transmembrane inactivator of alpha4 integrins. | LRP12 is an endogenous transmembrane inactivator of α4 integrins.
Huang M, Lu L, Lin C, Zheng Y, Pan X, Wang S, Chen S, Zhang Y, Liu C, Ge G, Zeng YA, Chen J. | 10/13/2023 |
| Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow. | Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
Kamioka Y, Ueda Y, Kondo N, Tokuhiro K, Ikeda Y, Bergmeier W, Kinashi T., Free PMC Article | 10/12/2023 |
| Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and alpha4beta7 Integrin and Direct Their Migration In Vitro. | Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro.
Manhas KR, Marshall PA, Wagner CE, Jurutka PW, Mancenido MV, Debray HZ, Blattman JN., Free PMC Article | 03/5/2022 |
| Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease. | Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T., Free PMC Article | 03/5/2022 |
| Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival. | Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival.
Hathi D, Chanswangphuwana C, Cho N, Fontana F, Maji D, Ritchey J, O'Neal J, Ghai A, Duncan K, Akers WJ, Fiala M, Vij R, DiPersio JF, Rettig M, Shokeen M., Free PMC Article | 02/26/2022 |
| VCAM1-alpha4beta1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells. | VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.
Abe K, Kon S, Kameyama H, Zhang J, Morohashi KI, Shimamura K, Abe SI., Free PMC Article | 12/11/2021 |
| Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the alpha4-Integrin Deficient NOD Mouse. | Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the α4-Integrin Deficient NOD Mouse.
Oulghazi S, Wegner SK, Spohn G, Müller N, Harenkamp S, Stenzinger A, Papayannopoulou T, Bonig H., Free PMC Article | 07/10/2021 |
| Integrin alpha4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation. | Integrin α4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation.
Hashimoto D, Semba S, Tsuda M, Kurokawa T, Kitamura N, Yasuda K, Gong JP, Tanaka S. | 01/16/2021 |
| The results demonstrate that circulating plasmacytoid dendritic cells are actively recruited into the CNS during acute experimental autoimmune encephalomyelitis through a mechanism largely dependent on CD49d/CD29-integrins. | CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation.
Garnier A, Laffont S, Garnier L, Kaba E, Deutsch U, Engelhardt B, Guéry JC. | 05/30/2020 |
| inhibition of FAK activity may reduce VCAM-1 expression within lymph nodes and thus reduce metastasis of alpha4 integrin-expressing melanoma to lymph nodes. | FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression.
Jeong K, Murphy JM, Rodriguez YAR, Kim JS, Ahn EE, Lim SS., Free PMC Article | 11/9/2019 |
| results establish ROS-elicited glutathionylation and its modulation by Grx1 as pivotal regulatory mechanisms controlling alpha4 integrin affinity and neutrophil mobilization from the bone marrow under physiological conditions. | Glutaredoxin 1 up-regulates deglutathionylation of α4 integrin and thereby restricts neutrophil mobilization from bone marrow.
You Y, Chen J, Zhu F, Xu Q, Han L, Gao X, Zhang X, Luo HR, Miao J, Sun X, Ren H, Du Y, Guo L, Wang X, Wang Y, Chen S, Huang N, Li J., Free PMC Article | 05/4/2019 |
| the data suggest that CXCR3 and the integrin alpha4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after Murine Cytomegalovirus infection. | The Chemokine Receptor CXCR3 Promotes CD8(+) T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection.
Caldeira-Dantas S, Furmanak T, Smith C, Quinn M, Teos LY, Ertel A, Kurup D, Tandon M, Alevizos I, Snyder CM., Free PMC Article | 10/6/2018 |
| As blockade of PI3Kgamma or integrin alpha4 prevents accumulation of myeloid-derived suppressor cells and reduces myeloid cell expression of immunosuppressive factors that stimulate tumor immune escape, these results highlight PI3Kgamma and integrin alpha4 as targets for the design of cancer therapeutics. | PI3Kγ Activates Integrin α(4) and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.
Foubert P, Kaneda MM, Varner JA., Free PMC Article | 06/30/2018 |
| integrin alpha4beta1 mediates the inhibitory effect of oncofetal Fibronectin both in vitro as well as in vivo. | An O-Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin.
Sens C, Altrock E, Rau K, Klemis V, von Au A, Pettera S, Uebel S, Damm T, Tiwari S, Moser M, Nakchbandi IA. | 01/13/2018 |
| investigation of the role of alpha4 integrin and the therapeutic effect of HCA3551, a newly synthesized orally active small molecule alpha4 integrin antagonist, in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease | The role of α4 integrin in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease: an infectious animal model for multiple sclerosis (MS).
Hirano Y, Kobayashi K, Tomiki H, Inaba Y, Ichikawa M, Kim BS, Koh CS., Free PMC Article | 11/4/2017 |
| AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD. | Blockade of αEβ7 integrin suppresses accumulation of CD8(+) and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.
Zundler S, Schillinger D, Fischer A, Atreya R, López-Posadas R, Watson A, Neufert C, Atreya I, Neurath MF. | 10/21/2017 |
| Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respectively; expression of the latter was upregulated in obesity. | A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity.
Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T., Free PMC Article | 08/19/2017 |
| uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology | Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis.
Glatigny S, Wagner CA, Bettelli E., Free PMC Article | 07/29/2017 |
| Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking. | Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.
Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W., Free PMC Article | 07/15/2017 |
| this study shows that alpha4beta1 integrin mediates memory CD8+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus | α(4) β(1) integrin promotes accumulation of tissue-resident memory CD8(+) T cells in salivary glands.
Woyciechowski S, Hofmann M, Pircher H. | 07/8/2017 |
| The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon. | β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.
Schippers A, Muschaweck M, Clahsen T, Tautorat S, Grieb L, Tenbrock K, Gaßler N, Wagner N., Free PMC Article | 12/17/2016 |
| Integrin a4b7 is essential for suppression of experimental colitis as it regulates the colonic Treg cell population and innate immunity. | Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity.
Zhang HL, Zheng YJ, Pan YD, Xie C, Sun H, Zhang YH, Yuan MY, Song BL, Chen JF. | 12/17/2016 |
| These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1. | Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.
Kanemaru K, Noguchi E, Tokunaga T, Nagai K, Hiroyama T, Nakamura Y, Tahara-Hanaoka S, Shibuya A., Free PMC Article | 07/2/2016 |