| Dopachrome tautomerase is a retinoblastoma-specific gene, and its proximal promoter is preferentially active in human retinoblastoma cells. | Dopachrome tautomerase is a retinoblastoma-specific gene, and its proximal promoter is preferentially active in human retinoblastoma cells.
Moolsuwan K, Permpoon T, Sae-Lee C, Uiprasertkul M, Boonyaratanakornkit V, Yenchitsomanus PT, Poungvarin N, Atchaneeyasakul LO., Free PMC Article | 10/29/2022 |
| Protein Biochemistry and Molecular Modeling of the Intra-Melanosomal Domain of Human Recombinant Tyrp2 Protein and OCA8-Related Mutant Variants. | Protein Biochemistry and Molecular Modeling of the Intra-Melanosomal Domain of Human Recombinant Tyrp2 Protein and OCA8-Related Mutant Variants.
Dolinska MB, Woods T, Osuna I, Sergeev YV., Free PMC Article | 03/12/2022 |
| Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies. | Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
Zhang J, Yu R, Guo X, Zou Y, Chen S, Zhou K, Chen Y, Li Y, Gao S, Wu Y., Free PMC Article | 11/27/2021 |
| Biallelic mutations in L-dopachrome tautomerase (DCT) cause infantile nystagmus and oculocutaneous albinism. | Biallelic mutations in L-dopachrome tautomerase (DCT) cause infantile nystagmus and oculocutaneous albinism.
Volk AE, Hedergott A, Preising M, Rading S, Fricke J, Herkenrath P, Nürnberg P, Altmüller J, von Ameln S, Lorenz B, Neugebauer A, Karsak M, Kubisch C. | 07/17/2021 |
| Evaluation of the effect of narrow band-ultraviolet B on the expression of tyrosinase, TYRP-1, and TYRP-2 mRNA in vitiligo skin and their correlations with clinical improvement: A retrospective study. | Evaluation of the effect of narrow band-ultraviolet B on the expression of tyrosinase, TYRP-1, and TYRP-2 mRNA in vitiligo skin and their correlations with clinical improvement: A retrospective study.
Awad SS, Moftah NH, Rashed LA, Touni AA, Telep RAA. | 06/5/2021 |
| TGF-beta and GLI2-specific TRP2 repression in melanoma cells involves direct mechanisms that occur in addition to MITF downregulation by TGF-beta and GLI2. Two functional GLI2 binding sites identified within the TRP2 promoter that are critical for TGF-beta and GLI2 responsiveness, one of them overlapping a CREB binding site. GLI2 and CREB competing for the same cis-element is associated with opposite transcriptional ou... | Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor-β and the Kruppel-like transcription factor GLI2.
Pierrat MJ, Marsaud V, Mauviel A, Javelaud D. | 04/4/2020 |
| High DCT expression is associated with progressive multiple sclerosis. | MIF and D-DT are potential disease severity modifiers in male MS subjects.
Benedek G, Meza-Romero R, Jordan K, Zhang Y, Nguyen H, Kent G, Li J, Siu E, Frazer J, Piecychna M, Du X, Sreih A, Leng L, Wiedrick J, Caillier SJ, Offner H, Oksenberg JR, Yadav V, Bourdette D, Bucala R, Vandenbark AA., Free PMC Article | 06/30/2018 |
| High DCT expression is associated with HPV16 Infection. | The Role of DCT in HPV16 Infection of HaCaTs.
Aksoy P, Meneses PI., Free PMC Article | 08/19/2017 |
| Data indicate that the caveolin-1 (CAV1) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent. | Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression.
Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CVA, Negroiu G., Free PMC Article | 12/17/2016 |
| The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes. | DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability.
Ainger SA, Yong XL, Wong SS, Skalamera D, Gabrielli B, Leonard JH, Sturm RA. | 08/1/2015 |
| Report dopachrome tautomerase expression in mealanocytic tumors. | Value of dopachrome tautomerase detection in the assessment of melanocytic tumors.
Filimon A, Zurac SA, Milac AL, Sima LE, Petrescu SM, Negroiu G. | 01/3/2015 |
| The results suggested that the miRNAs may be involved in MITF regulation of TYR, TYRP1 and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease. | The changes of microRNA expression profiles and tyrosinase related proteins in MITF knocked down melanocytes.
Wang P, Li Y, Hong W, Zhen J, Ren J, Li Z, Xu A. | 03/2/2013 |
| Data suggest that macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK in LKB1 wild type and LKB1 mutant non-small cell lung carcinomas cells. | Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas.
Brock SE, Rendon BE, Yaddanapudi K, Mitchell RA., Free PMC Article | 01/26/2013 |
| human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 pathway | HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.
Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO., Free PMC Article | 07/19/2010 |
| Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population. | [Association study of Trp2 allele polymorphism with degenerative disc disease in a Chinese Han nationality].
Song HF, Wu ZH, Fei Q, Yan JZ, Liu Z, Zhang JG, Li SG, Qiu GX, Song HF, Wu ZH, Fei Q, Yan JZ, Liu Z, Zhang JG, Li SG, Qiu GX. | 06/14/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articles[Association study of Trp2 allele polymorphism with degenerative disc disease in a Chinese Han nationality].
Song HF, Wu ZH, Fei Q, Yan JZ, Liu Z, Zhang JG, Li SG, Qiu GX, Song HF, Wu ZH, Fei Q, Yan JZ, Liu Z, Zhang JG, Li SG, Qiu GX. Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation.
Edwards M, Bigham A, Tan J, Li S, Gozdzik A, Ross K, Jin L, Parra EJ. | 04/7/2010 |
| Expression profiling demonstrated that the DCT-expressing cell population expressed adrenergic and muscarinic receptors and displayed transcriptional profiles distinct from dermal melanocytes | Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.
Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA, Patel VV., Free PMC Article | 01/21/2010 |
| Tyrosinase-, gp100-, or TRP-2-specific CD8(+) T cells could not be identified in the peripheral blood of individuals with vitiligo [TRP-2]. | Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients.
Adams S, Lowes MA, O'Neill DW, Schachterle S, Romero P, Bhardwaj N. | 01/21/2010 |
| tyrosinase-related protein 2 (TRP-2) transcript is not detected in the peripheral blood mononuclear cells (PBMC) of vitiligo patients | Absence of tyrosinase-related protein-2/dopachrome tautomerase transcripts in PBMCs from vitiligo patients.
Bam M, Bagchi T. | 01/21/2010 |
| TRP-2 acts on quinone metabolites other than DOPAchrome, e.g., in the catecholamine pathway, and limits their deleterious effects. | TRP-2 expression protects HEK cells from dopamine- and hydroquinone-induced toxicity.
Michard Q, Commo S, Rocchetti J, El Houari F, Alleaume AM, Wakamatsu K, Ito S, Bernard BA. | 01/21/2010 |
| we studied a possible role of dopachrome tautomerase in the oxidative stress response in the amelanotic WM35 melanoma cell line. | TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress.
Michard Q, Commo S, Belaidi JP, Alleaume AM, Michelet JF, Daronnat E, Eilstein J, Duche D, Marrot L, Bernard BA. | 01/21/2010 |
| We observe strong evidence for positive selection for DCT in Asians | Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans.
Alonso S, Izagirre N, Smith-Zubiaga I, Gardeazabal J, Díaz-Ramón JL, Díaz-Pérez JL, Zelenika D, Boyano MD, Smit N, de la Rúa C., Free PMC Article | 01/21/2010 |
| Anemonin, an active compound of C. crassifolia, inhibits melanin synthesis by inhibiting the transcription of the genes encoding TYR, TRP1, and TRP2. | Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes.
Huang YH, Lee TH, Chan KJ, Hsu FL, Wu YC, Lee MH. | 01/21/2010 |
| Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients. | Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.
Paschen A, Jing W, Drexler I, Klemm M, Song M, Müller-Berghaus J, Nguyen XD, Osen W, Stevanovic S, Sutter G, Schadendorf D. | 01/21/2010 |
| Data suggest that OTX2 may regulate retinal pigment epithelium (RPE)-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE. | OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium.
Takeda K, Yokoyama S, Yasumoto Ki, Saito H, Udono T, Takahashi K, Shibahara S. | 01/21/2010 |