| Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the Pathogenesis of Placenta Accreta Spectrum: A Case-control Study. | Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the Pathogenesis of Placenta Accreta Spectrum: A Case-control Study.
Badary DM, Elsaied H, Abdel-Fadeil MR, Ali MK, Abou-Taleb H, Iraqy HM. | 10/28/2024 |
| NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer. | NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer.
Márquez-González RM, Saucedo-Sariñana AM, de Jesús Tovar-Jacome C, Barros-Núñez P, Gallegos-Arreola MP, Orozco-Gutiérrez MH, Mariscal-Ramírez I, Pineda-Razo TD, Alcaraz-Wong AA, Marín-Contreras ME, Rosales-Reynoso MA. | 04/2/2024 |
| Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer. | Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer.
Serwer T, Wahid M, Imtiaz F, Memon AS. | 03/4/2024 |
| An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease. | An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease.
Hua Y, Han W, Zhou L, Gao J, Zhao J, Song N, Hu B, Yao Q, Liu Y, Xu D, Lu Y, Fan Y., Free PMC Article | 07/7/2023 |
| Mirror movements and callosal dysgenesis in a family with a DCC mutation: Neuropsychological and neuroimaging outcomes. | Mirror movements and callosal dysgenesis in a family with a DCC mutation: Neuropsychological and neuroimaging outcomes.
Knight JL, Barker MS, Edwards TJ, Barnby JM, Richards LJ, Robinson GA. | 04/4/2023 |
| Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children. | Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children.
Restrepo-Lozano JM, Pokhvisneva I, Wang Z, Patel S, Meaney MJ, Silveira PP, Flores C., Free PMC Article | 06/11/2022 |
| Genetic Susceptibility of DCC Gene in Gallbladder Cancer in Kashmir and Meta-Analysis. | Genetic Susceptibility of DCC Gene in Gallbladder Cancer in Kashmir and Meta-Analysis.
Malik MA, Malik SA, Haq MG, Bangri SA, Ahmad SZ, Shah OJ, Shah ZA. | 04/23/2022 |
| Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study. | Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study.
Inderjeet K, Adole PS, Vinod KV, Pillai AA., Free PMC Article | 03/5/2022 |
| DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. | DCC gene network in the prefrontal cortex is associated with total brain volume in childhood.
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA., Free PMC Article | 10/30/2021 |
| Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. | Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.
Jasmin M, Ahn EH, Voutilainen MH, Fombonne J, Guix C, Viljakainen T, Kang SS, Yu LY, Saarma M, Mehlen P, Ye K., Free PMC Article | 10/9/2021 |
| A novel homozygous frameshift mutation in the DCC gene in a Pakistani family with autosomal recessive horizontal gaze palsy with progressive scoliosis-2 with impaired intellectual development. | A novel homozygous frameshift mutation in the DCC gene in a Pakistani family with autosomal recessive horizontal gaze palsy with progressive scoliosis-2 with impaired intellectual development.
Zaka A, Shahzad S, Rao HZ, Hashim Y, Basit S. | 07/10/2021 |
| A novel heterozygous loss-of-function DCC Netrin 1 receptor variant in prenatal agenesis of corpus callosum and review of the literature. | A novel heterozygous loss-of-function DCC Netrin 1 receptor variant in prenatal agenesis of corpus callosum and review of the literature.
Sagi-Dain L, Kurolap A, Ilivitzki A, Mory A, Paperna T, Regeneron Genetics Center, Kedar R, Gonzaga-Jauregui C, Peleg A, Baris Feldman H. | 01/2/2021 |
| Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder. | Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder.
Li Y, Qiu S, Zhong W, Li Y, Liu Y, Cheng Y, Liu Y. | 12/26/2020 |
| Callosal agenesis and congenital mirror movements: outcomes associated with DCC mutations. | Callosal agenesis and congenital mirror movements: outcomes associated with DCC mutations.
Spencer-Smith M, Knight JL, Lacaze E, Irc5 Consortium, Depienne C, Lockhart PJ, Richards LJ, Heron D, Leventer RJ, Robinson GA. | 10/31/2020 |
| Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression. | Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression.
Boussouar A, Tortereau A, Manceau A, Paradisi A, Gadot N, Vial J, Neves D, Larue L, Battistella M, Leboeuf C, Lebbé C, Janin A, Mehlen P. | 08/22/2020 |
| Study provides evidence that a functional SNP rs12607853 in a putative miRNA binding site in the DCC 3 '-UTR may act by affecting the binding of hsa-miR-422a. This SNP-modified posttranscriptional gene regulation represents a potential pathogenic mechanism of opioid addiction. | microRNA-422a Inhibits DCC Expression in a Manner Dependent on SNP rs12607853.
Li Y, Shi X, Cai X, Zhu Y, Chen Y, Lai J. | 04/25/2020 |
| humans with DCC mutations exhibit sensory mirroring suggesting a deficit in nociceptive topognosis | DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans.
da Silva RV, Johannssen HC, Wyss MT, Roome RB, Bourojeni FB, Stifani N, Marsh APL, Ryan MM, Lockhart PJ, Leventer RJ, Richards LJ, Rosenblatt B, Srour M, Weber B, Zeilhofer HU, Kania A. | 06/1/2019 |
| The results suggest that netrin-1 promotes glioma cell proliferation by activating NF-kappaB signaling via UNC5A. | Netrin-1 promotes glioma growth by activating NF-κB via UNC5A.
Chen JY, He XX, Ma C, Wu XM, Wan XL, Xing ZK, Pei QQ, Dong XP, Liu DX, Xiong WC, Zhu XJ., Free PMC Article | 01/19/2019 |
| This study implicates DCC and NTN1 mutations in the pathophysiology of CHH consistent with the role of these two genes in the ontogeny of GnRH neurons in mice. | DCC/NTN1 complex mutations in patients with congenital hypogonadotropic hypogonadism impair GnRH neuron development.
Bouilly J, Messina A, Papadakis G, Cassatella D, Xu C, Acierno JS, Tata B, Sykiotis G, Santini S, Sidis Y, Elowe-Gruau E, Phan-Hug F, Hauschild M, Bouloux PM, Quinton R, Lang-Muritano M, Favre L, Marino L, Giacobini P, Dwyer AA, Niederländer NJ, Pitteloud N. | 01/5/2019 |
| Based on the variable expressivity and incomplete penetrance present in heterozygous carriers of a DCC variant, classification and clinical interpretation of missense variants is challenging in the absence of evidence of pathogenicity originated from functional studies | Novel DCC variants in congenital mirror movements and evaluation of disease-associated missense variants.
Bierhals T, Korenke GC, Baethmann M, Marín LL, Staudt M, Kutsche K. | 09/29/2018 |
| Study results indicate that DCC controls corticospinal tract midline crossing in both humans and mice, and that this process is non cell-autonomous in mice. | Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline.
Welniarz Q, Morel MP, Pourchet O, Gallea C, Lamy JC, Cincotta M, Doulazmi M, Belle M, Méneret A, Trouillard O, Ruiz M, Brochard V, Meunier S, Trembleau A, Vidailhet M, Chédotal A, Dusart I, Roze E., Free PMC Article | 09/1/2018 |
| rs2229080 and rs7504990 polymorphisms in DCC might be related with breast cancer susceptibility in Chinese women. | Genetic association of deleted in colorectal carcinoma variants with breast cancer risk: A case-control study.
Liu X, Wang X, Fu SW, Wang M, Kang H, Guan H, Zhang S, Ma X, Lin S, Liu K, Feng Y, Dai C, Dai Z., Free PMC Article | 12/30/2017 |
| Somatic DCC mutations are associated with metastatic NUT midline carcinoma. | Uncommon somatic mutations in metastatic NUT midline carcinoma.
Cavalieri S, Stathis A, Fabbri A, Sonzogni A, Perrone F, Tamborini E, Pelosi G, de Braud F, Platania M. | 12/9/2017 |
| Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. | TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.
Plooster M, Menon S, Winkle CC, Urbina FL, Monkiewicz C, Phend KD, Weinberg RJ, Gupton SL., Free PMC Article | 11/18/2017 |
| Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. | Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer.
Forrest CM, McNair K, Vincenten MC, Darlington LG, Stone TW., Free PMC Article | 09/30/2017 |