| The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis. | The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis.
Hironaka T, Takizawa N, Yamauchi Y, Horii Y, Nakaya M., Free PMC Article | 03/31/2023 |
| Drebrin promotes lung adenocarcinoma cell migration through inducing integrin beta1 endocytosis. | Drebrin promotes lung adenocarcinoma cell migration through inducing integrin β1 endocytosis.
Yu Q, Tang F, Cao F, Tan X, Weng L, Sun L. | 10/15/2022 |
| Effects of neuronal drebrin on actin dynamics. | Effects of neuronal drebrin on actin dynamics.
Grintsevich EE. | 01/29/2022 |
| Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia. | Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia.
Maki H, Yoshimi A, Shimada T, Arai S, Morita K, Kamikubo Y, Ikegawa M, Kurokawa M. | 04/24/2021 |
| Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis. | Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis.
Dombroski TCD, Peixoto-Santos JE, Maciel K, Baqui MMA, Velasco TR, Sakamoto AC, Assirati JA, Carlotti CG, Machado HR, Sousa GK, Hanamura K, Leite JP, Costa da Costa J, Palmini AL, Paglioli E, Neder L, Spreafico R, Shirao T, Garbelli R, Martins AR. | 01/23/2021 |
| TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma. | TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
Guoren Z, Zhaohui F, Wei Z, Mei W, Yuan W, Lin S, Xiaoyue X, Xiaomei Z, Bo S., Free PMC Article | 01/9/2021 |
| we show that drebrin and hCDC14A regulate the recruitment of the actin organizer Arp2 to centrosomes. In addition, during ciliogenesis hCDC14A also regulates endocytosis and targeting of myosin Va vesicles to the basal body in a drebrin-independent manner, indicating that it impacts primary cilia formation in a multilayered manner. | The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.
Uddin B, Partscht P, Chen NP, Neuner A, Weiß M, Hardt R, Jafarpour A, Heßling B, Ruppert T, Lorenz H, Pereira G, Schiebel E., Free PMC Article | 08/17/2019 |
| Study results showed that the vincristine resistant colon cancer cell line has reduced DBN1 expression which may be related to changes in the drug-target sites. | Downregulation of DBN1 is related to vincristine resistance in colon cancer cells.
Han Z, Huang H, Zhang T. | 08/3/2019 |
| Drebrin may regulate activities of epigenetic reader ZMYND8 via its cytoplasmic sequestration. | The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.
Yao N, Li J, Liu H, Wan J, Liu W, Zhang M. | 07/28/2018 |
| Inhibition of cortactin or dynamin-2 abrogated the increased virus entry observed in DBN1-deficient cells, suggesting that DBN1 suppresses dynamin-mediated endocytosis via interaction with cortactin. | Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.
Li B, Ding S, Feng N, Mooney N, Ooi YS, Ren L, Diep J, Kelly MR, Yasukawa LL, Patton JT, Yamazaki H, Shirao T, Jackson PK, Greenberg HB., Free PMC Article | 04/28/2018 |
| Lack of drebrin leads to the dysfunction of cell-cell communication, resulting in aberrant migration of metastatic cancer cells, aberrant synaptic function in dementia, and rupture of endothelial integrity. | General Introduction to Drebrin.
Shirao T, Sekino Y. | 12/2/2017 |
| these results contribute to the current understanding of cell-cell junction regulation, introducing a new function of drebrin as a stabilizer of endothelial integrity. | Drebrin's Role in the Maintenance of Endothelial Integrity.
Rehm K, Linder S. | 12/2/2017 |
| drebrin has to be added to the list of actin-binding proteins regulating actin dynamics of mesangial cell processes and foot processes of podocytes. It will be important to determine its role in hereditary and acquired glomerulopathies. | Drebrin in Renal Glomeruli.
Ludwig-Peitsch WK. | 12/2/2017 |
| Upregulation of drebrin was noted in several types of cancers, e.g., basal cell carcinomas for which it may serve as marker, liver metastases of colon carcinomas, and bladder cancer, suggesting that it is involved in regulating actin dynamics during tumor development, progression, and metastasis. | Drebrin at Junctional Plaques.
Ludwig-Peitsch WK. | 12/2/2017 |
| Our work has shown that the immunosuppressant compound BTP2, which blocks Ca(2+) influx into cells, interacts with the actin-reorganizing protein, drebrin. Here we review the role of drebrin in the regulation of calcium signaling, with a focus on immune cells. | Drebrin Regulation of Calcium Signaling in Immune Cells.
Pabon J, Law MK, August A. | 12/2/2017 |
| through its interaction with CXCR4 and the actin cytoskeleton, drebrin regulates T cell activation. CD4(+) T cells are one of the main targets for the human immunodeficiency virus (HIV)-1. | Role of Drebrin at the Immunological Synapse.
Rocha-Perugini V, Gordon-Alonso M, Sánchez-Madrid F., Free PMC Article | 12/2/2017 |
| further studies on drebrin and its binding proteins will be of great importance to elucidate the pathologies of various diseases and may contribute to their medical treatment and diagnostics development. | Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain.
Yamazaki H, Shirao T. | 12/2/2017 |
| Taking into account that connexin-43 (Cx43) (together with Cx30) is heavily expressed in astrocytes and that drebrin supports cell-cell contacts, the understanding of details of how brain cells live and die reveals molecular pathology involved in neurodegeneration, Alzheimer's disease (AD), other cognitive disorders, and aging | Drebrins and Connexins: A Biomedical Perspective.
Majoul IV, Ernesti JS, Butkevich EV, Duden R. | 12/2/2017 |
| These observations indicate that drebrin loss in dendritic spines occurs at the prodromal stage of Alzheimer's disease (AD), before the density and morphology of dendritic spines change. Quantitation of drebrin may be a possible tool for diagnosing the prodromal stage of AD, before dementia development in AD. | Drebrin in Alzheimer's Disease.
Ishizuka Y, Hanamura K. | 12/2/2017 |
| One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified. | Phosphorylation of Drebrin and Its Role in Neuritogenesis.
Gordon-Weeks PR. | 12/2/2017 |
| Cancer cell motility and invasion are crucial elements in the metastatic cascade and involve dramatic changes in cellular morphology that are associated with dynamic remodelling of the cytoskeleton. Interestingly, it now appears that drebrin could deliver this role during cancer development. | The Role of Drebrin in Cancer Cell Invasion.
Dart AE, Gordon-Weeks PR. | 12/2/2017 |
| Drebrin reduces SMC activation through its interaction with the actin cytoskeleton but independently of its interaction with Homer scaffolds to prevent neointima formation. | The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.
Stiber JA, Wu JH, Zhang L, Nepliouev I, Zhang ZS, Bryson VG, Brian L, Bentley RC, Gordon-Weeks PR, Rosenberg PB, Freedman NJ., Free PMC Article | 06/24/2017 |
| Exploring the relationship between drebrin and cognitive function may provide insight into the early prevention of cognitive impairment and in the diagnosis and treatment of Alzheimer's disease. | Drebrin and cognitive impairment.
Ma L, Li Y, Wang R. | 07/30/2016 |
| Drebrin is critical for progranulin-dependent activation of the Akt and MAPK pathways and modulates motility, invasion and anchorage-independent growth in bladder neoplasms. | A novel role for drebrin in regulating progranulin bioactivity in bladder cancer.
Xu SQ, Buraschi S, Morcavallo A, Genua M, Shirao T, Peiper SC, Gomella LG, Birbe R, Belfiore A, Iozzo RV, Morrione A., Free PMC Article | 03/5/2016 |
| The study compared the proteome profiles of the human colon adenocarcinoma cell line HCT-116 with its metastatic derivative E1. DBN1 was found to be overexpressed in E1 as compared to HCT-116 cells. | iTRAQ analysis of colorectal cancer cell lines suggests Drebrin (DBN1) is overexpressed during liver metastasis.
Lin Q, Tan HT, Lim TK, Khoo A, Lim KH, Chung MC. | 01/24/2015 |