| IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. | IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation.
Zwicky P, Ingelfinger F, Silva de Melo BM, Ruchti F, Schärli S, Puertas N, Lutz M, Phan TS, Kündig TM, Levesque MP, Maul JT, Schlapbach C, LeibundGut-Landmann S, Mundt S, Becher B. | 03/12/2022 |
| Autocrine TGF-beta1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rbeta2 Downregulation. | Autocrine TGF-β1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rβ2 Downregulation.
Choi G, Na H, Kuen DS, Kim BS, Chung Y., Free PMC Article | 04/13/2021 |
| Morphological and Functional Characterization of IL-12Rbeta2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation. | Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation.
Regoli M, Man A, Gicheva N, Dumont A, Ivory K, Pacini A, Morucci G, Branca JJV, Lucattelli M, Santosuosso U, Narbad A, Gulisano M, Bertelli E, Nicoletti C., Free PMC Article | 08/17/2019 |
| These results provide a new pathway of Th1 response regulation where IL-12 secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells. | Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.
Sela U, Park CG, Park A, Olds P, Wang S, Steinman RM, Fischetti VA., Free PMC Article | 07/2/2016 |
| in neonatal mice, IL-12 uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 differentiation | Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn.
Hoeman CM, Dhakal M, Zaghouani AA, Cascio JA, Wan X, Khairallah MT, Chen W, Zaghouani H., Free PMC Article | 08/31/2013 |
| survival of secondary LVS challenge was not strictly dependent on IL-12Rbeta2 | IL-12Rβ2 is critical for survival of primary Francisella tularensis LVS infection.
Melillo AA, Foreman O, Elkins KL., Free PMC Article | 07/20/2013 |
| Data indicate that delayed induction of the IL-12Rbeta2 receptor component after STAT1 activation helped ensure that Treg cells do not readily complete STAT4-dependent Th1 cell development and lose their ability to suppress effector T cell proliferation. | T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.
Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ., Free PMC Article | 12/22/2012 |
| Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4. | The composition and signaling of the IL-35 receptor are unconventional.
Collison LW, Delgoffe GM, Guy CS, Vignali KM, Chaturvedi V, Fairweather D, Satoskar AR, Garcia KC, Hunter CA, Drake CG, Murray PJ, Vignali DA., Free PMC Article | 06/12/2012 |
| IL-12R-beta2 signaling is essential for Plasmodium berghei ANKA-induced experimental cerebral malaria development | IL-12Rβ2 is essential for the development of experimental cerebral malaria.
Fauconnier M, Palomo J, Bourigault ML, Meme S, Szeremeta F, Beloeil JC, Danneels A, Charron S, Rihet P, Ryffel B, Quesniaux VF. | 03/31/2012 |
| Data show that T(H)1 differentiation was impaired in Il2(-/-) T cells but was restored by IL-12Rbeta2 expression. | Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
Liao W, Lin JX, Wang L, Li P, Leonard WJ., Free PMC Article | 07/23/2011 |
| gamma rays cause a decrease in IFN-gamma, IL-12p70, IL-12 receptor beta2, and STAT4 and an increase in IL-4 in natural killer cells | Chronic effects of single and fractionated γ-irradiation on an impairment of Th1-related immune response.
Park HR, Jo SK, Eom HS. | 07/2/2011 |
| Freshly isolated ex vivo T helper (Th)17 cells display restricted expression from Il12rb2 due to the presence of repressive chromatin remodeling. | Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells.
Bending D, Newland S, Krejcí A, Phillips JM, Bray S, Cooke A. | 05/28/2011 |
| This study delineates a new role of IL-12R beta 1 and IL-12R beta 2 for the expression of iNOS and production of NO in microglia that may participate in the pathogenesis of neuroinflammatory diseases. | IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1.
Jana M, Dasgupta S, Pal U, Pahan K., Free PMC Article | 01/21/2010 |
| Studies established the concept that the IL-12Rbeta2 gene is a gatekeeper from cancer. | Interleukin-12 receptor beta2: from cytokine receptor to gatekeeper gene in human B-cell malignancies.
Pistoia V, Cocco C, Airoldi I. | 01/21/2010 |
| Results show that direct IL-12 receptor signaling to CD8(+) T cells determines the cell fate decision between short-lived effector cells and memory precursor effector cells, which is dependent on pathogen-induced local cytokine milieu. | Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cells.
Keppler SJ, Theil K, Vucikuja S, Aichele P. | 01/21/2010 |
| Data show that the loss of IL-12R engagement does not appear to alter T-cell expansion but leads to their accumulation in secondary lymphoid organs. | IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo.
Gyülvészi G, Haak S, Becher B. | 01/21/2010 |
| IL12p40(2) induces the expression of this IL16 via IL-12Rbeta1 but not IL-12Rbeta2. | IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages.
Jana M, Pahan K., Free PMC Article | 01/21/2010 |
| IL-12Rbeta2 regulates both the number and functional maturity of regulatory T cells by a novel mechanism for the regulation of autoimmune diseases via the IL-12 pathway. | IL-12R beta 2 promotes the development of CD4+CD25+ regulatory T cells.
Zhao Z, Yu S, Fitzgerald DC, Elbehi M, Ciric B, Rostami AM, Zhang GX., Free PMC Article | 01/21/2010 |
| Contribution of IL-12rb2 mediated feedback loop to Th1 cell differentiation. | Contribution of IL-12R mediated feedback loop to Th1 cell differentiation.
Becskei A, Grusby MJ., Free PMC Article | 01/21/2010 |
| T-bet mediates STAT1-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2. | T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells.
Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM. | 01/21/2010 |
| IL-12Rbeta2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response. | IL-12Rbeta2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response.
Chakir H, Campos-Neto A, Mojibian M, Webb JR. | 01/21/2010 |
| Expression of the IL-12 beta 2 receptor is upregulated in both microglia and splenic macrophages. | Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia.
Li J, Gran B, Zhang GX, Ventura ES, Siglienti I, Rostami A, Kamoun M. | 01/21/2010 |
| Contrary to the expectation that the absence of IL-12RB2 would protect from experimental autoimmune encephalitis, IL-12RB2-deficient mice develop earlier and more severe disease, with extensive demyelination and central nervous system inflammation. | Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system.
Zhang GX, Gran B, Yu S, Li J, Siglienti I, Chen X, Kamoun M, Rostami A. | 01/21/2010 |
| expression of GATA-3 in developing Th1 cells suppresses Th1 development through downregulation of Stat4 rather through downregulation of the IL-12Rbeta2 chain | GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet.
Usui T, Nishikomori R, Kitani A, Strober W. | 01/21/2010 |
| By the third week of infection we found decreased IL-12Rbeta2 expression by BABL/c splenocytes, corresponding to their inability to produce interferon-gamma in Brucella recall responses at this time as reported previously. | Treatment of Brucella-susceptible mice with IL-12 increases primary and secondary immunity.
Sathiyaseelan J, Goenka R, Parent M, Benson RM, Murphy EA, Fernandes DM, Foulkes AS, Baldwin CL. | 01/21/2010 |