| Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults. | Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults.
Rinne N, Wikman P, Sahari E, Salmi J, Einarsdóttir E, Kere J, Alho K., Free PMC Article | 04/17/2024 |
| A novel homozygous splice variant in DNAAF4 is associated with asthenozoospermia. | A novel homozygous splice variant in DNAAF4 is associated with asthenozoospermia.
Zhu X, Chen C, Song J, Dong S, Zeng X, Niu Z, Sha Y, Zhang X., Free PMC Article | 11/3/2023 |
| Novel dynein axonemal assembly factor 1 mutations identified using wholeexome sequencing in patients with primary ciliary dyskinesia. | Novel dynein axonemal assembly factor 1 mutations identified using whole‑exome sequencing in patients with primary ciliary dyskinesia.
Zhou L, Li Z, Du C, Chen C, Sun Y, Gu L, Zhou F, Song Y., Free PMC Article | 05/29/2021 |
| that endogenous DYX1C1 localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium | Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.
Tammimies K, Bieder A, Lauter G, Sugiaman-Trapman D, Torchet R, Hokkanen ME, Burghoorn J, Castrén E, Kere J, Tapia-Páez I, Swoboda P., Free PMC Article | 09/9/2017 |
| promoter SNP rs12899331 of DYX1C1 may contribute towards the manifestation of DD. This study supports the association of DYX1C1 with DD in an Indian population | Association of SNPs of DYX1C1 with developmental dyslexia in an Indian population.
Venkatesh SK, Siddaiah A, Padakannaya P, Ramachandra NB. | 08/9/2014 |
| results demonstrate that DYX1C1 can modulate the expression of genes involved in cell migration and nervous system development and associates with a number of cytoskeletal proteins. | Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins.
Tammimies K, Vitezic M, Matsson H, Le Guyader S, Bürglin TR, Ohman T, Strömblad S, Daub CO, Nyman TA, Kere J, Tapia-Páez I. | 05/3/2014 |
| DYX1C1 is required for axonemal dynein assembly and ciliary motility. | DYX1C1 is required for axonemal dynein assembly and ciliary motility.
Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, Köhler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K, UK10K, Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H., Free PMC Article | 11/30/2013 |
| The results of this study do not provide evidence for association between the putatively functional single nucleotide polymorphisms -3G/A and 1249G/T in DYX1C1 and reading disabilities. | A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1.
Tran C, Gagnon F, Wigg KG, Feng Y, Gomez L, Cate-Carter TD, Kerr EN, Field LL, Kaplan BJ, Lovett MW, Barr CL., Free PMC Article | 09/21/2013 |
| Gene-by-environment effects were found between some specified environmental moderators (i.e. maternal smoke during pregnancy, birth weight and socio-economic status) and the DYX1C1-1259C/G marker | An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes.
Mascheretti S, Bureau A, Battaglia M, Simone D, Quadrelli E, Croteau J, Cellino MR, Giorda R, Beri S, Maziade M, Marino C. | 07/6/2013 |
| results suggested that the 931C > T variant in KIAA0319, but not the -3G > A in DYX1C1, was significantly associated with the risk of dyslexia | Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis.
Zou L, Chen W, Shao S, Sun Z, Zhong R, Shi J, Miao X, Song R. | 05/11/2013 |
| DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene. | Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population.
Zhang Y, Li J, Tardif T, Burmeister M, Villafuerte SM, McBride-Chang C, Li H, Shi B, Liang W, Zhang Z, Shu H., Free PMC Article | 03/23/2013 |
| The results of this study found that DYX1C1 gene contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. | Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure.
Darki F, Peyrard-Janvid M, Matsson H, Kere J, Klingberg T. | 03/2/2013 |
| Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia. | Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
Ivliev AE, 't Hoen PA, van Roon-Mom WM, Peters DJ, Sergeeva MG., Free PMC Article | 09/15/2012 |
| the expression of DYX1C1 in breast cancer is associated with several clinicopathological parameters and that loss of DYX1C1 correlates with a more aggressive disease, in turn indicating that DYX1C1 is a potential prognostic biomarker in breast cancer. | The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer.
Rosin G, Hannelius U, Lindström L, Hall P, Bergh J, Hartman J, Kere J., Free PMC Article | 07/21/2012 |
| A single nucleotide polymorphism previously shown to be associated with dyslexia and located in the cis-regulatory region of DYX1C1 may alter the epigenetic and endocrine regulation of this gene. | The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation.
Tammimies K, Tapia-Páez I, Rüegg J, Rosin G, Kere J, Gustafsson JÅ, Nalvarte I., Free PMC Article | 07/21/2012 |
| findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity. | Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children.
Lim CK, Ho CS, Chou CH, Waye MM., Free PMC Article | 09/24/2011 |
| No statistically significant associations were found between DCDC2 or DYX1C1 and language phenotypes. Both DCDC2 and DYX1C1 DD susceptibility genes appear to have a pleiotropic role on mathematics but not language phenotypes. | Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia.
Marino C, Mascheretti S, Riva V, Cattaneo F, Rigoletto C, Rusconi M, Gruen JR, Giorda R, Lazazzera C, Molteni M., Free PMC Article | 07/2/2011 |
| At this point, there is no statistical evidence of association between the allelic variation in the three candidate genes and DD in our sample. | An examination of candidate gene SNPs for dyslexia in an Indian sample.
Venkatesh SK, Siddaiah A, Padakannaya P, Ramachandra NB. | 07/2/2011 |
| Association signals were detected for several single nucleotide polymorphisms within DYX1C1 with both the reading and spelling tests | Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.
Paracchini S, Ang QW, Stanley FJ, Monaco AP, Pennell CE, Whitehouse AJ., Free PMC Article | 06/18/2011 |
| Results suggest that DYX1C1 influences reading and spelling ability with additional effects on short-term information storage or rehearsal. Missense mutation rs17819126 is a potential functional basis for the association of DYX1C1 with dyslexia. | Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation.
Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, Wright MJ. | 05/7/2011 |
| Functional characterization of the homologous rat protein. | DYX1C1 functions in neuronal migration in developing neocortex.
Wang Y, Paramasivam M, Thomas A, Bai J, Kaminen-Ahola N, Kere J, Voskuil J, Rosen GD, Galaburda AM, Loturco JJ. | 03/1/2011 |
| The contribution of DYX1C1 to dyslexia in a sample of 366 trios of German descent, was investigated. | Further evidence for DYX1C1 as a susceptibility factor for dyslexia.
Dahdouh F, Anthoni H, Tapia-Páez I, Peyrard-Janvid M, Schulte-Körne G, Warnke A, Remschmidt H, Ziegler A, Kere J, Müller-Myhsok B, Nöthen MM, Schumacher J, Zucchelli M. | 01/21/2010 |
| DYX1C1 interacts with both ERs in the presence of 17beta-estradiol in neurons. | Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.
Massinen S, Tammimies K, Tapia-Páez I, Matsson H, Hokkanen ME, Söderberg O, Landegren U, Castrén E, Gustafsson JA, Treuter E, Kere J. | 01/21/2010 |
| The DYX1C1 is a novel Hsp70 and Hsp90-interacting co-chaperone protein and its expression is associated with malignancy. | A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer.
Chen Y, Zhao M, Wang S, Chen J, Wang Y, Cao Q, Zhou W, Liu J, Xu Z, Tong G, Li J. | 01/21/2010 |
| Alternatively spliced transcript variants of the DYX1C1 gene may be used as cancer biomarkers to detect colorectal cancer. | Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker.
Kim YJ, Huh JW, Kim DS, Bae MI, Lee JR, Ha HS, Ahn K, Kim TO, Song GA, Kim HS. | 01/21/2010 |