| A novel tumour suppressor gene, MDGA2, which is frequently inactivated by promoter methylation in Gastric cancer was identified. Promoter hypermethylation of MDGA2 represents a prognostic biomarker in patients with early stage Gastric cancer. | MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.
Wang K, Liang Q, Li X, Tsoi H, Zhang J, Wang H, Go MY, Chiu PW, Ng EK, Sung JJ, Yu J., Free PMC Article | 06/24/2017 |
| This finding provides further support for a link between variants in the MDGA2 gene and specific neuroticism-related phenotypes. | Evidence for associations between MDGA2 polymorphisms and harm avoidance: replication and extension of a genome-wide association finding.
Heck A, Pfister H, Czamara D, Müller-Myhsok B, Pütz B, Lucae S, Hennings J, Ising M. | 04/7/2012 |
| Polymorphisms of rs961616 in MAMDC1 gene were associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese population. | Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population.
Wu Q, Yu B, Chen Y, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Wan J, Zhang W. | 01/28/2012 |
| This study demonistrated suggested taht Rostral growth of commissural axons requires the cell adhesion molecule MDGA2 | Rostral growth of commissural axons requires the cell adhesion molecule MDGA2.
Joset P, Wacker A, Babey R, Ingold EA, Andermatt I, Stoeckli ET, Gesemann M., Free PMC Article | 09/17/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| A novel uncharacterized gene, MAMDC1 (MAM domain containing glycosylphosphatidylinositol anchor 2, also known as MDGA2, MIM 611128), represents a putative susceptibility gene for systemic lupus erythematosus. | Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).
Hellquist A, Zucchelli M, Lindgren CM, Saarialho-Kere U, Järvinen TM, Koskenmies S, Julkunen H, Onkamo P, Skoog T, Panelius J, Räisänen-Sokolowski A, Hasan T, Widen E, Gunnarson I, Svenungsson E, Padyukov L, Assadi G, Berglind L, Mäkelä VV, Kivinen K, Wong A, Cunningham Graham DS, Vyse TJ, D'Amato M, Kere J, Hellquist A, Zucchelli M, Lindgren CM, Saarialho-Kere U, Järvinen TM, Koskenmies S, Julkunen H, Onkamo P, Skoog T, Panelius J, Räisänen-Sokolowski A, Hasan T, Widen E, Gunnarson I, Svenungsson E, Padyukov L, Assadi G, Berglind L, Mäkelä VV, Kivinen K, Wong A, Cunningham Graham DS, Vyse TJ, D'Amato M, Kere J., Free PMC Articles: PMC2785483, PMC2785483 | 03/22/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesIdentification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).
Hellquist A, Zucchelli M, Lindgren CM, Saarialho-Kere U, Järvinen TM, Koskenmies S, Julkunen H, Onkamo P, Skoog T, Panelius J, Räisänen-Sokolowski A, Hasan T, Widen E, Gunnarson I, Svenungsson E, Padyukov L, Assadi G, Berglind L, Mäkelä VV, Kivinen K, Wong A, Cunningham Graham DS, Vyse TJ, D'Amato M, Kere J, Hellquist A, Zucchelli M, Lindgren CM, Saarialho-Kere U, Järvinen TM, Koskenmies S, Julkunen H, Onkamo P, Skoog T, Panelius J, Räisänen-Sokolowski A, Hasan T, Widen E, Gunnarson I, Svenungsson E, Padyukov L, Assadi G, Berglind L, Mäkelä VV, Kivinen K, Wong A, Cunningham Graham DS, Vyse TJ, D'Amato M, Kere J. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 01/20/2010 |
| No association of rs7151262 with neuroticism was found | Follow-up association study of novel neuroticism gene MAMDC1.
Hettema JM, van den Oord EJ, An SS, Kendler KS, Chen X., Free PMC Article | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.
Bucan M, Abrahams BS, Wang K, Glessner JT, Herman EI, Sonnenblick LI, Alvarez Retuerto AI, Imielinski M, Hadley D, Bradfield JP, Kim C, Gidaya NB, Lindquist I, Hutman T, Sigman M, Kustanovich V, Lajonchere CM, Singleton A, Kim J, Wassink TH, McMahon WM, Owley T, Sweeney JA, Coon H, Nurnberger JI, Li M, Cantor RM, Minshew NJ, Sutcliffe JS, Cook EH, Dawson G, Buxbaum JD, Grant SF, Schellenberg GD, Geschwind DH, Hakonarson H., Free PMC Article | 08/12/2009 |
| MAMDC1 gene is implicated in neuroticism. | Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism.
van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D, van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D. | 01/21/2010 |
| Genome-wide association study of gene-disease association. (HuGE Navigator) | Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism.
van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D, van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D. | 09/10/2008 |