| Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling. | Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.
Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA Jr, Penn RB, Kambayashi T, Deshpande DA., Free PMC Article | 12/25/2021 |
| The present study shows that a bipolar-risk allele of DGKH is associated with higher openness to experience, providing further evidence for the implication of this gene in the etiology of bipolar disorder. | Implication of the DGKH genotype in openness to experience, a premorbid personality trait of bipolar disorder.
Matsumoto Y, Suzuki A, Shirata T, Takahashi N, Noto K, Goto K, Otani K. | 01/26/2019 |
| This sstudy shown that the highest expression levels of DGKH in the human brain were found in the striatum. | Expressional profile of the diacylglycerol kinase eta gene DGKH.
Weißflog L, Becker N, Bossert N, Freudenberg F, Kittel-Schneider S, Reif A. | 02/3/2018 |
| DGKH is a replicated risk gene of bipolar disorder (BD). | DGKH genetic risk variant influences gene expression in bipolar affective disorder.
Kittel-Schneider S, Lorenz C, Auer J, Weißflog L, Reif A. | 11/25/2017 |
| several single variants and genes showed strong association with Panic Disorders, where DGKH was found to be the strongest Panic Disorder associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. | Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population.
Gregersen NO, Lescai F, Liang J, Li Q, Als T, Buttenschøn HN, Hedemand A, Biskopstø M, Wang J, Wang AG, Børglum AD, Mors O, Demontis D. | 09/23/2017 |
| DGKeta-Pleckstrin Homology Domain preferentially interacts with Phosphatidylinositol 4,5-Bisphosphate and has crucial roles in regulating the subcellular localization and physiological function of DGKeta. | The Pleckstrin Homology Domain of Diacylglycerol Kinase η Strongly and Selectively Binds to Phosphatidylinositol 4,5-Bisphosphate.
Kume A, Kawase K, Komenoi S, Usuki T, Takeshita E, Sakai H, Sakane F., Free PMC Article | 09/3/2016 |
| This study demonstrated that significant association of the DGKH risk haplotype with increased amygdala volume in Bipolar disorder, but not in schizophreia or healthy controls. | Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia.
Kittel-Schneider S, Wobrock T, Scherk H, Schneider-Axmann T, Trost S, Zilles D, Wolf C, Schmitt A, Malchow B, Hasan A, Backens M, Reith W, Falkai P, Gruber O, Reif A. | 11/14/2015 |
| These findings implicate a link between nucleotide variant of DGKH and a cause for a complex-trait disease, calcium oxalate stone | Association study of DGKH gene polymorphisms with calcium oxalate stone in Chinese population.
Xu Y, Zeng G, Mai Z, Ou L. | 10/31/2015 |
| DGKK variants are associated with hypospadias | Diacylglycerol kinase K variants impact hypospadias in a California study population.
Carmichael SL, Mohammed N, Ma C, Iovannisci D, Choudhry S, Baskin LS, Witte JS, Shaw GM, Lammer EJ., Free PMC Article | 02/16/2013 |
| expressions of DGKeta and DGKzeta were increased and decreased, respectively, whereas those of DGKgamma and DGKepsilon remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts. | Differential regulation of diacylglycerol kinase isoform in human failing hearts.
Bilim O, Shishido T, Toyama S, Suzuki S, Sasaki T, Kitahara T, Sadahiro M, Takeishi Y, Kubota I., Free PMC Article | 11/24/2012 |
| Differential effects of DGKH in healthy controls vs the bipolar high-risk group manifest as a failure to disengage default-mode regions in those at familial risk carrying the risk haplotype. | Effect of variation in diacylglycerol kinase η (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder.
Whalley HC, Papmeyer M, Romaniuk L, Johnstone EC, Hall J, Lawrie SM, Sussmann JE, McIntosh AM., Free PMC Article | 11/24/2012 |
| Four DGKH markers are linked to adult attention-hyperactivity disorder and seven to unipolar depression, making DGKH a risk factor gene for bipolar disorder, unipolar depression and adult attention-deficit hyperactivity disorder. | Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD.
Weber H, Kittel-Schneider S, Gessner A, Domschke K, Neuner M, Jacob CP, Buttenschon HN, Boreatti-Hümmer A, Volkert J, Herterich S, Baune BT, Gross-Lesch S, Kopf J, Kreiker S, Nguyen TT, Weissflog L, Arolt V, Mors O, Deckert J, Lesch KP, Reif A., Free PMC Article | 06/9/2012 |
| Increased gene expression of diacylglycerol kinase eta is found in brain tissue from patients with bipolar disorder. | Increased gene expression of diacylglycerol kinase η in bipolar disorder.
Moya PR, Murphy DL, McMahon FJ, Wendland JR., Free PMC Article | 12/24/2011 |
| Although the association was not strong, the result of this study would support the association between DGKH and BD. | Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples.
Takata A, Kawasaki H, Iwayama Y, Yamada K, Gotoh L, Mitsuyasu H, Miura T, Kato T, Yoshikawa T, Kanba S. | 09/3/2011 |
| The results of tisd support DGKH as shared risk factor of bipolar disorder and schizophrenia in the Chinese Han population. | Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population.
Zeng Z, Wang T, Li T, Li Y, Chen P, Zhao Q, Liu J, Li J, Feng G, He L, Shi Y, Zeng Z, Wang T, Li T, Li Y, Chen P, Zhao Q, Liu J, Li J, Feng G, He L, Shi Y. | 08/20/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| No significant association after multiple-testing correction between any of the single nucleotide polymorphisms in DGKH and bipolar disorder, was found. | No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
Tesli M, Kähler AK, Andreassen BK, Werge T, Mors O, Mellerup E, Koefoed P, Melle I, Morken G, Wirgenes KV, Andreassen OA, Djurovic S, Tesli M, Kähler AK, Andreassen BK, Werge T, Mors O, Mellerup E, Koefoed P, Melle I, Morken G, Wirgenes KV, Andreassen OA, Djurovic S. | 02/15/2010 |
| While negative, our findings do not exclude an involvement of DGKH and NR1D1 in lithium prophylaxis. | Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
Manchia M, Squassina A, Congiu D, Chillotti C, Ardau R, Severino G, Del Zompo M, Manchia M, Squassina A, Congiu D, Chillotti C, Ardau R, Severino G, Del Zompo M. | 02/8/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
Manchia M, Squassina A, Congiu D, Chillotti C, Ardau R, Severino G, Del Zompo M, Manchia M, Squassina A, Congiu D, Chillotti C, Ardau R, Severino G, Del Zompo M. | 12/2/2009 |
| DGKeta acts as a novel critical regulatory component of the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade via a previously unidentified mechanism. | Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.
Yasuda S, Kai M, Imai S, Takeishi K, Taketomi A, Toyota M, Kanoh H, Sakane F., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesCommon SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population.
Zeng Z, Wang T, Li T, Li Y, Chen P, Zhao Q, Liu J, Li J, Feng G, He L, Shi Y, Zeng Z, Wang T, Li T, Li Y, Chen P, Zhao Q, Liu J, Li J, Feng G, He L, Shi Y. No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
Tesli M, Kähler AK, Andreassen BK, Werge T, Mors O, Mellerup E, Koefoed P, Melle I, Morken G, Wirgenes KV, Andreassen OA, Djurovic S, Tesli M, Kähler AK, Andreassen BK, Werge T, Mors O, Mellerup E, Koefoed P, Melle I, Morken G, Wirgenes KV, Andreassen OA, Djurovic S. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
Yosifova A, Mushiroda T, Stoianov D, Vazharova R, Dimova I, Karachanak S, Zaharieva I, Milanova V, Madjirova N, Gerdjikov I, Tolev T, Velkova S, Kirov G, Owen MJ, O'Donovan MC, Toncheva D, Nakamura Y. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
Ollila HM, Soronen P, Silander K, Palo OM, Kieseppä T, Kaunisto MA, Lönnqvist J, Peltonen L, Partonen T, Paunio T. | 04/8/2009 |
| diacylglycerol kinase eta (DGKH) is association in the etiology of bipolar disorder. | A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ, Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ., Free PMC Articles: PMC2527618, PMC2527618 | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ, Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ., Free PMC Articles: PMC2527618, PMC2527618 | 03/13/2008 |
| alternative splicing of the human DGK eta gene generates at least two isoforms with distinct biochemical and cell biological properties responding to different cellular metabolic requirements | Identification and characterization of two splice variants of human diacylglycerol kinase eta.
Murakami T, Sakane F, Imai S, Houkin K, Kanoh H. | 01/21/2010 |