| Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis. | Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis.
Shichi S, Sugiyama K, Asahi Y, Shirakawa C, Nakamoto H, Kimura S, Wakizaka K, Aiyama T, Nagatsu A, Orimo T, Kakisaka T, Taketomi A., Free PMC Article | 05/9/2024 |
| Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase alpha (DGKalpha)/NOX4 axis. | Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis.
Chen J, Zhao D, Zhang L, Zhang J, Xiao Y, Wu Q, Wang Y, Zhan Q. | 03/11/2024 |
| Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase alpha (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma. | Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma.
Liu W, Wang H, Zhao Q, Tao C, Qu W, Hou Y, Huang R, Sun Z, Zhu G, Jiang X, Fang Y, Gao J, Wu X, Yang Z, Ping R, Chen J, Yang R, Chu T, Zhou J, Fan J, Tang Z, Yang D, Shi Y., Free PMC Article | 02/22/2024 |
| Targeting diacylglycerol kinase alpha impairs lung tumorigenesis by inhibiting cyclin D3. | Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.
Zhou D, Liu T, Rao X, Jie X, Chen Y, Wu Z, Deng H, Zhang D, Wang J, Wu G., Free PMC Article | 05/12/2023 |
| DGKA interacts with SRC/FAK to promote the metastasis of non-small cell lung cancer. | DGKA interacts with SRC/FAK to promote the metastasis of non-small cell lung cancer.
Fu L, Deng R, Huang Y, Yang X, Jiang N, Zhou J, Lin C, Chen S, Wu L, Cui Q, Yun J. | 04/30/2022 |
| Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling. | Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.
Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA Jr, Penn RB, Kambayashi T, Deshpande DA., Free PMC Article | 12/25/2021 |
| DGKA Mediates Resistance to PD-1 Blockade. | DGKA Mediates Resistance to PD-1 Blockade.
Fu L, Li S, Xiao W, Yu K, Li S, Yuan S, Shen J, Dong X, Fang Z, Zhang J, Chen S, Li W, You H, Xia X, Kang T, Tan J, Chen G, Yang AK, Gao Y, Zhou P. | 12/4/2021 |
| DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling. | DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Li J, Pan C, Boese AC, Kang J, Umano AD, Magliocca KR, Yang W, Zhang Y, Lonial S, Jin L, Kang S., Free PMC Article | 11/6/2021 |
| Diacylglycerol kinases regulate TRPV1 channel activity. | Diacylglycerol kinases regulate TRPV1 channel activity.
Liu L, Yudin Y, Rohacs T., Free PMC Article | 01/2/2021 |
| Upon neutrophil stimulation, DGK-alpha activation is necessary for migration and a productive response. This paper focuses on the role of DGK-alpha in obstructive respiratory diseases, including asthma and chronic obstructive pulmonary disease, but also rare genetic diseases such as alpha-1-antitrypsin deficiency. [review] | DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases.
Baldanzi G, Malerba M., Free PMC Article | 04/18/2020 |
| This study presents the first crystal structure of EF-hand domains of diacylglycerol kinase alpha in its Ca(2+) bound form and characterize Ca(2+) -induced conformational changes, which likely regulates intra-molecular interactions. | Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains.
Takahashi D, Suzuki K, Sakamoto T, Iwamoto T, Murata T, Sakane F., Free PMC Article | 04/11/2020 |
| This novel study demonstrates efficient ablation of diacylglycerol kinase in human CAR-T cells that leads to improved antitumor immunity and may have significant impact in human cancer immunotherapy | CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells.
Jung IY, Kim YY, Yu HS, Lee M, Kim S, Lee J. | 09/28/2019 |
| Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) | Diacylglycerol kinases in cancer.
Mérida I, Torres-Ayuso P, Ávila-Flores A, Arranz-Nicolás J, Andrada E, Tello-Lafoz M, Liébana R, Arcos R. | 11/18/2017 |
| DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, and its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression. | Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Poli A, Fiume R, Baldanzi G, Capello D, Ratti S, Gesi M, Manzoli L, Graziani A, Suh PG, Cocco L, Follo MY. | 08/12/2017 |
| LIPFDGKA might serve as a potential possible biomarkers for diagnosis of gastric cancer, and their downregulation may bring new perspective into the investigation of gastric cancer prognosis | Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer.
Kong Y, Zheng Y, Jia Y, Li P, Wang Y., Free PMC Article | 03/18/2017 |
| An abandoned compound that also inhibits serotonin receptors may have more translational potential as a DGKa inhibitor, but more potent and specific DGKa inhibitors are sorely needed | Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer.
Purow B., Free PMC Article | 09/3/2016 |
| Decreased DNA methylation at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis. | Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis.
Weigel C, Veldwijk MR, Oakes CC, Seibold P, Slynko A, Liesenfeld DB, Rabionet M, Hanke SA, Wenz F, Sperk E, Benner A, Rösli C, Sandhoff R, Assenov Y, Plass C, Herskind C, Chang-Claude J, Schmezer P, Popanda O., Free PMC Article | 07/30/2016 |
| Redundant and specialized roles for diacylglycerol kinases alpha and zeta in the control of T cell functions. | Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions.
Mérida I, Andrada E, Gharbi SI, Ávila-Flores A. | 01/30/2016 |
| These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells. | The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.
Rainero E, Cianflone C, Porporato PE, Chianale F, Malacarne V, Bettio V, Ruffo E, Ferrara M, Benecchia F, Capello D, Paster W, Locatelli I, Bertoni A, Filigheddu N, Sinigaglia F, Norman JC, Baldanzi G, Graziani A., Free PMC Article | 01/31/2015 |
| DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1 | Diacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling.
Xie S, Naslavsky N, Caplan S., Free PMC Article | 01/24/2015 |
| High diacylglycerol kinase alpha expression is associated with glioblastoma. | A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival.
Kefas B, Floyd DH, Comeau L, Frisbee A, Dominguez C, Dipierro CG, Guessous F, Abounader R, Purow B., Free PMC Article | 07/12/2014 |
| DGKalpha is involved in hepatocellular carcinoma progression by activation of the MAPK pathway. | Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway.
Takeishi K, Taketomi A, Shirabe K, Toshima T, Motomura T, Ikegami T, Yoshizumi T, Sakane F, Maehara Y. | 11/17/2012 |
| DGK-alpha was more highly expressed in CD8-tumor-infiltrating T cellscompared with that in CD8non-tumor kidney-infiltrating lymphocytes. | High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention.
Prinz PU, Mendler AN, Masouris I, Durner L, Oberneder R, Noessner E. | 08/18/2012 |
| Antigen-specific CD8-positive T cells from DGKalpha-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion. | Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.
Shin J, O'Brien TF, Grayson JM, Zhong XP., Free PMC Article | 06/2/2012 |
| SAP-mediated inhibition of DGKalpha sustains diacylglycerol signaling, thereby regulating T cell activation | SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.
Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato PE, Filigheddu N, Mesturini R, Song S, Schweighoffer T, Patrussi L, Baldari CT, Zhong XP, van Blitterswijk WJ, Sinigaglia F, Nichols KE, Rubio I, Parolini O, Graziani A., Free PMC Article | 01/14/2012 |