| DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-kappaB and TGF-beta/Smad signalling pathway. | DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-κB and TGF-β/Smad signalling pathway.
Lin J, Li B, Xu Q, Liu YS, Kang YL, Wang X, Wang Y, Lei Y, Bai YL, Li XM, Zhou J. | 06/7/2024 |
| Dachshund Homolog 1: Unveiling Its Potential Role in Megakaryopoiesis and Bacillus anthracis Lethal Toxin-Induced Thrombocytopenia. | Dachshund Homolog 1: Unveiling Its Potential Role in Megakaryopoiesis and Bacillus anthracis Lethal Toxin-Induced Thrombocytopenia.
Lin GL, Chang HH, Lin WT, Liou YS, Lai YL, Hsieh MH, Chen PK, Liao CY, Tsai CC, Wang TF, Chu SC, Kau JH, Huang HH, Hsu HL, Sun DS., Free PMC Article | 04/2/2024 |
| DACH1 regulates macrophage activation and tumour progression in hypopharyngeal squamous cell carcinoma. | DACH1 regulates macrophage activation and tumour progression in hypopharyngeal squamous cell carcinoma.
Li W, Xu L, Cao J, Ge J, Liu X, Liu P, Teng Y, Wang S, Sun Y, Liu M, Tian L. | 09/8/2023 |
| Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity. | Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J, Xie J. | 05/17/2023 |
| DACH1 inhibits the proliferation and migration of papillary thyroid carcinoma. | DACH1 inhibits the proliferation and migration of papillary thyroid carcinoma.
Liang S, Xu Q, Liu B, Hu R, Lai J, Wang W, Yu X, Gou J, Wang L, Chen Y, Ji Q, Zhou J. | 02/28/2023 |
| Role of DACH1 on Proliferation, Invasion, and Apoptosis in Human Lung Adenocarcinoma Cells. | Role of DACH1 on Proliferation, Invasion, and Apoptosis in Human Lung Adenocarcinoma Cells.
Yu J, Jiang P, Zhao K, Chen Z, Zuo T, Chen B. | 04/9/2022 |
| Biallelic variant in DACH1, encoding Dachshund Homolog 1, defines a novel candidate locus for recessive postaxial polydactyly type A. | Biallelic variant in DACH1, encoding Dachshund Homolog 1, defines a novel candidate locus for recessive postaxial polydactyly type A.
Umair M, Palander O, Bilal M, Almuzzaini B, Alam Q, Ahmad F, Younus M, Khan A, Waqas A, Rafeeq MM, Alfadhel M. | 04/9/2022 |
| Mechanistic insight of DACH1 receptor in the development of carcinoma insurgence through MD simulation studies. | Mechanistic insight of DACH1 receptor in the development of carcinoma insurgence through MD simulation studies.
Hassan M, Zahid S, Shahzadi S, Malik E, Zaib S, Iqbal J, Shamim S, Malik A. | 03/19/2022 |
| [Methylation status of DACH1 gene in esophageal cancer and its clinical significance]. | [Methylation status of DACH1 gene in esophageal cancer and its clinical significance].
Liu Y, Li J, Ding H, Xu C, Kou X. | 10/16/2021 |
| Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis. | Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis.
Doke T, Huang S, Qiu C, Liu H, Guan Y, Hu H, Ma Z, Wu J, Miao Z, Sheng X, Zhou J, Cao A, Li J, Kaufman L, Hung A, Brown CD, Pestell R, Susztak K., Free PMC Article | 10/9/2021 |
| Upregulation of microRNA1403p mediates dachshund family transcription factor 1 expression in immunoglobulin A nephropathy through cell cycledependent mechanisms. | Upregulation of microRNA‑140‑3p mediates dachshund family transcription factor 1 expression in immunoglobulin A nephropathy through cell cycle‑dependent mechanisms.
Zhou X, Lu Y, Guo P, Zhou C., Free PMC Article | 05/15/2021 |
| Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling. | Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling.
Hu X, Zhang L, Li Y, Ma X, Dai W, Gao X, Rao X, Fu G, Wang R, Pan M, Guo Q, Xu X, Zhou Y, Gao J, Zhang Z, Cai S, Peng J, Hua G., Free PMC Article | 04/17/2021 |
| DACH1 mutation frequency in endometrial cancer is associated with high tumor mutation burden. | DACH1 mutation frequency in endometrial cancer is associated with high tumor mutation burden.
Riggs MJ, Lin N, Wang C, Piecoro DW, Miller RW, Hampton OA, Rao M, Ueland FR, Kolesar JM., Free PMC Article | 03/20/2021 |
| MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1. | MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1.
Wang R, Shen J, Su N, Wang Q, Zhang M, Liu C. | 10/31/2020 |
| MicroRNA-200c promotes tumor cell proliferation and migration by directly targeting dachshund family transcription factor 1 by the Wnt/beta-catenin signaling pathway in nasopharyngeal carcinoma. | MicroRNA-200c promotes tumor cell proliferation and migration by directly targeting dachshund family transcription factor 1 by the Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma.
Cao W, Sun J. | 09/26/2020 |
| Results found that DACH1 is lower expressed in endometrial carcinoma tissues compared with normal endometrium and is positively correlated with progesterone receptor and resistance to progestin. | DACH1 suppresses epithelial to mesenchymal transition (EMT) through Notch1 pathway and reverses progestin resistance in endometrial carcinoma.
Zhou Q, Li W, Kong D, Liu Z, Shi Z, Ma X, Li Y, Jiang J., Free PMC Article | 08/12/2020 |
| SNP rs9529895 is significantly related to the risk for endometrial cancer and progression-free survival | Correlation between single nucleotide polymorphisms of DACH1 gene microRNA binding site and susceptibility of patients with endometrial cancer.
Xu L, Qiu Y, Feng L, Zhou L, Chen X, Yu D., Free PMC Article | 07/25/2020 |
| HOTAIR was up-regulated and miR-217 was down-regulated in non-small cell lung cancer (NSCLC) cell lines. Silencing of HOTAIR significantly repressed cell proliferation and inhibited cell migration and invasion in H1299 and A549 cells by facilitating miR-217 expression. Bioinformatics analysis and Luciferase reporter assay confirmed that DACH1 was a target of miR-217. | Long non-coding RNA HOTAIR regulates the development of non-small cell lung cancer through miR-217/DACH1 signaling pathway.
Chen SS, Peng M, Zhou GZ, Pu YC, Yi MC, Zhu Y, Jiang B. | 07/25/2020 |
| Study demonstrate that DACH1 is expressed in neuroepithelial cells and ventricular radial glial cells of the human forebrain from the earliest stage analyzed (5 pcw) and continues to be expressed until midfetal stages (21 pcw). | Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development.
Castiglioni V, Faedo A, Onorati M, Bocchi VD, Li Z, Iennaco R, Vuono R, Bulfamante GP, Muzio L, Martino G, Sestan N, Barker RA, Cattaneo E., Free PMC Article | 07/18/2020 |
| Aberrant expression of DACH1 was associated with the clinical survival of glioma patients. Furthermore, overexpression of DACH1 rescued the promotive effects of miR-6807-3p in glioma. Based on these findings, a novel miR-6807-3p may act as a glioma enhancer by targeting DACH1. | MicroRNA-6807-3p promotes the tumorigenesis of glioma by targeting downstream DACH1.
Lu GF, Geng F, Xiao Z, Chen YS, Han Y, You CY, Gong NL, Xie ZM, Pan M. | 06/20/2020 |
| Dach1 is a transcription factor that is important for podocyte differentiation and proper kidney function. | The transcription factor Dach1 is essential for podocyte function.
Endlich N, Kliewe F, Kindt F, Schmidt K, Kotb AM, Artelt N, Lindenmeyer MT, Cohen CD, Döring F, Kuss AW, Amann K, Moeller MJ, Kabgani N, Blumenthal A, Endlich K., Free PMC Article | 10/26/2019 |
| Dachshund family transcription factor (DACH1) is significantly higher in female breast cancer (FBC) than male breast cancer (MBC). Body mass index and DACH1 are correlated with MBC prognosis. | Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.
Cui Q, Kong D, Li Z, Ahiable P, Wang K, Wu K, Wu G. | 09/21/2019 |
| The decrease of SIX1 facilitated the expression of DACH1, thus activated the expression of p53 and suppressed the progression of HCC both in vitro and in vivo. | SIX1 and DACH1 influence the proliferation and apoptosis of hepatocellular carcinoma through regulating p53.
Cheng Q, Ning D, Chen J, Li X, Chen XP, Jiang L., Free PMC Article | 06/23/2019 |
| DACH1 and CD44 inversely related in breast cancer, different grade tumors and different subtypes. DACH1 was negatively associated with CD44 in vitro and vivo. DACH1 served as a good prognostic marker, and CD44 was an unfavorable element of breast cancer patients. | DACH1 suppresses breast cancer as a negative regulator of CD44.
Xu H, Yu S, Yuan X, Xiong J, Kuang D, Pestell RG, Wu K., Free PMC Article | 01/12/2019 |
| DACH1 expression is decreased in glomerulopathy imply a potential role for DACH1 in the this development of human chornic glomerulopathy. | Decreased DACH1 expression in glomerulopathy is associated with disease progression and severity.
Liu QQ, Zhou YQ, Liu HQ, Qiu WH, Liu H, Hu TY, Xu Q, Lv YM, Wu KM., Free PMC Article | 02/24/2018 |