| Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma. | Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma.
Tao L, Wang Y, Shen Z, Cai J, Zheng J, Xia S, Lin Z, Wan Z, Qi H, Jin R, Wang L, Xu J, Liang X., Free PMC Article | 02/15/2024 |
| The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4. | The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
Chen W, Hu L, Lu X, Wang X, Zhao C, Guo C, Li X, Ding Y, Zhao H, Tong D, Wang L, Huang C., Free PMC Article | 08/30/2023 |
| Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy. | Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
Jepsen MR, Østergaard JA, Conover CA, Wogensen L, Birn H, Krag SP, Fenton RA, Oxvig C. | 06/18/2022 |
| IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction. | IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction.
Wo D, Chen J, Li Q, Ma E, Yan H, Peng J, Zhu W, Fang Y, Ren DN., Free PMC Article | 09/18/2021 |
| Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence. | Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence.
Alessio N, Squillaro T, Di Bernardo G, Galano G, De Rosa R, Melone MAB, Peluso G, Galderisi U., Free PMC Article | 03/27/2021 |
| Igfbp4 is required for inguinal fat expansion in female mice but not in male mice. However, gonadal WAT expansion, which is prevented by estrogen during high-fat diet, does not require Igfbp4. | IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots.
Maridas DE, DeMambro VE, Le PT, Mohan S, Rosen CJ., Free PMC Article | 10/21/2017 |
| IGFBP-4 modulates the skeleton in a gender-specific manner, acting as both a cell autonomous and cell non-autonomous factor. | IGFBP-4 regulates adult skeletal growth in a sex-specific manner.
Maridas DE, DeMambro VE, Le PT, Nagano K, Baron R, Mohan S, Rosen CJ., Free PMC Article | 06/24/2017 |
| exerts a negative effect on basal intestinal growth but plays a positive regulatory role in the intestinotropic actions of GLP-2 | IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine.
Austin K, Imam NA, Pintar JE, Brubaker PL., Free PMC Article | 03/28/2015 |
| IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion. | Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S., Free PMC Article | 10/18/2014 |
| Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development. | Expression of insulin-like growth factor binding proteins during mouse cochlear development.
Okano T, Kelley MW. | 04/19/2014 |
| SOX9 is a transcriptional regulator of IGFBP-4 and that SOX9-induced activation of IGFBP-4 may be one of the mechanisms by which SOX9 suppresses cell proliferation and progression of colon cancer. | SOX9 directly regulates IGFBP-4 in the intestinal epithelium.
Shi Z, Chiang CI, Mistretta TA, Major A, Mori-Akiyama Y., Free PMC Article | 09/14/2013 |
| findings indicate that the defect in p53 function and the increased proteolysis of IGFBP-4, we had observed, represent two components of the same pathway, which contributes to the oncogenic function of Skp2B | Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4.
Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D., Free PMC Article | 12/31/2011 |
| Inactivation of IGFBP4 diminished the anabolic effects of PAPP-A on bone. | Inactivation of insulin-like-growth factors diminished the anabolic effects of pregnancy-associated plasma protein-A (PAPP-A) on bone in mice.
Phang D, Rehage M, Bonafede B, Hou D, Xing W, Mohan S, Wergedal JE, Qin X. | 09/20/2010 |
| SOD1(G93A) mutant transgenic mice as a model of amyotrophic lateral sclerosis (ALS) and immunohistochemical studies to investigate the changes of insulin-like growth factor-binding protein 4 (IGFBP4) in the central nervous system. | Immunohistochemical study on the distribution of insulin-like growth factor-binding protein 4 in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.
Kang DW, Chung YH, Lee JC, Bang JS, Kim D, Kim SS, Kim KY, Lee WB, Cha CI. | 01/21/2010 |
| Data suggest that loss of expression of IGFBPs (IGFBP-3 and IGFBP-4) in tumor cells treated with EGFR tyrosine kinase inhibitors derepresses IGFIR signaling, which in turn mediates resistance to EGFR antagonists. | Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.
Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, Rinehart C, Seidel B, Yee D, Arteaga CL, Engelman JA., Free PMC Article | 01/21/2010 |
| IGFBP-4 is an inhibitor of the canonical Wnt signalling required for cardiogenesis and provides a molecular link between insulin-like growth factor signalling and Wnt signalling | IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.
Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I. | 01/21/2010 |
| Results indicate that IGFBP-4 functions as a local reservoir to optimize IGF-II actions needed for normal embryogenesis, and also establish that IGFBP-4 proteolysis is required to activate most, if not all, IGF-II mediated growth-promoting activity. | Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo.
Ning Y, Schuller AG, Conover CA, Pintar JE., Free PMC Article | 01/21/2010 |
| IGFBP-4 may have a role in increasing necrosis and apoptosis, but in decreasing mitosis | Increased apoptosis and decreased proliferation of colorectal cancer cells using insulin-like growth factor binding protein-4 gene delivered locally by gene transfer.
Durai R, Yang SY, Sales KM, Seifalian AM, Goldspink G, Winslet MC. | 01/21/2010 |
| Overexpression of Hbegf in transgenic mice downregulates Igfbp4. | Heparin-binding EGF-like growth factor (HB-EGF) overexpression in transgenic mice downregulates insulin-like growth factor binding protein (IGFBP)-3 and -4 mRNA.
Provenzano AP, Besner GE, James PF, Harding PA. | 01/21/2010 |
| Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice | Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy.
Zhang M, Smith EP, Kuroda H, Banach W, Chernausek SD, Fagin JA. | 01/21/2010 |
| Crystallization, heparin and IGF binding, and osteogenic activity of IGFBP4 in its native conformation | Synthesis of the blood circulating C-terminal fragment of insulin-like growth factor (IGF)-binding protein-4 in its native conformation. Crystallization, heparin and IGF binding, and osteogenic activity.
Fernández-Tornero C, Lozano RM, Rivas G, Jiménez MA, Ständker L, Díaz-Gonzalez D, Forssmann WG, Cuevas P, Romero A, Giménez-Gallego G. | 01/21/2010 |
| This study demonstrates that ES of muscle cells in vitro not only directly modulates the gene expression of contractile proteins but also modulates proteins that are part of the IGF regulatory system, in particular IGFBP-4. | Electrical stimulation modulates IGF binding protein transcript levels in C2C12 myotubes.
Bayol S, Brownson C, Loughna PT. | 01/21/2010 |
| IGFBP-4 is a potential growth inhibitor of lymphoid tissues. | Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice.
Zhou R, Flaswinkel H, Schneider MR, Lahm H, Hoeflich A, Wanke R, Wolf E. | 01/21/2010 |
| provide direct evidence for combinatorial effects of IGFBP-3, -4, and -5 in both metabolism and at least some soft tissues | Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5.
Ning Y, Schuller AG, Bradshaw S, Rotwein P, Ludwig T, Frystyk J, Pintar JE. | 01/21/2010 |