| Disabled-2: a protein up-regulated by high molecular weight hyaluronan has both tumor promoting and tumor suppressor roles in ovarian cancer. | Disabled-2: a protein up-regulated by high molecular weight hyaluronan has both tumor promoting and tumor suppressor roles in ovarian cancer.
Price ZK, Lokman NA, Sugiyama M, Koya Y, Yoshihara M, Oehler MK, Kajiyama H, Ricciardelli C., Free PMC Article | 11/2/2023 |
| Genetic polymorphism of the Dab2 gene and its association with Type 2 Diabetes Mellitus in the Chinese Uyghur population. | Genetic polymorphism of the Dab2 gene and its association with Type 2 Diabetes Mellitus in the Chinese Uyghur population.
Li YP, Adi D, Wang YH, Wang YT, Li XL, Fu ZY, Liu F, Aizezi A, Abuzhalihan J, Gai M, Ma X, Li XM, Xie X, Ma Y., Free PMC Article | 06/30/2023 |
| Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic Pathways. | Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic Pathways.
Price ZK, Lokman NA, Yoshihara M, Kajiyama H, Oehler MK, Ricciardelli C., Free PMC Article | 01/14/2023 |
| MicroRNA93 knockdown inhibits acute myeloid leukemia cell growth via inactivating the PI3K/AKT pathway by upregulating DAB2. | MicroRNA‑93 knockdown inhibits acute myeloid leukemia cell growth via inactivating the PI3K/AKT pathway by upregulating DAB2.
Huang J, Xiao R, Wang X, Khadka B, Fang Z, Yu M, Zhang L, Wu J, Liu J., Free PMC Article | 01/29/2022 |
| Proper E-cadherin membrane location in colon requires Dab2 and it modifies by inflammation and cancer. | Proper E-cadherin membrane location in colon requires Dab2 and it modifies by inflammation and cancer.
Vazquez-Carretero MD, García-Miranda P, Balda MS, Matter K, Ilundáin AA, Peral MJ. | 09/11/2021 |
| Dynamic multimerization of Dab2-Myosin VI complexes regulates cargo processivity while minimizing cortical actin reorganization. | Dynamic multimerization of Dab2-Myosin VI complexes regulates cargo processivity while minimizing cortical actin reorganization.
Rai A, Vang D, Ritt M, Sivaramakrishnan S., Free PMC Article | 08/28/2021 |
| A dynamic Dab2 keeps myosin VI stably on track. | A dynamic Dab2 keeps myosin VI stably on track.
Cirilo JA Jr, Yengo CM., Free PMC Article | 08/14/2021 |
| Involvement of Disabled-2 on skin fibrosis in systemic sclerosis. | Involvement of Disabled-2 on skin fibrosis in systemic sclerosis.
Mei X, Zhao H, Huang Y, Tang Y, Shi X, Pu W, Jiang S, Ma Y, Zhang Y, Bai L, Tu W, Zhao Y, Jin L, Wu W, Wang J, Liu Q. | 05/22/2021 |
| Loss of Disabled-2 Expression in Pancreatic Cancer Progression. | Loss of Disabled-2 Expression in Pancreatic Cancer Progression.
Hocevar BA., Free PMC Article | 10/24/2020 |
| Our data indicates that the AA genotype of rs2855512 and rs2255280 in the Dab2 gene may be a genetic marker of coronary artery disease risk in Chinese Han population. | Dab2 gene variant is associated with increased coronary artery disease risk in Chinese Han population.
Wang Y, Wang Y, Adi D, He X, Liu F, Abudesimu A, Fu Z, Ma Y., Free PMC Article | 08/1/2020 |
| MiR-93 promoted PC progression and metastasis by repressing DAB2. | MiR-93 functions as a tumor promoter in prostate cancer by targeting disabled homolog 2 (DAB2) and an antitumor polysaccharide from green tea (Camellia sinensis) on their expression.
Yang K, Li YW, Gao ZY, Xiao W, Li TQ, Song W, Zheng J, Chen H, Chen GH, Zou HY. | 05/18/2019 |
| Putative causal genes were enriched for proximal tubule expression and endolysosomal function, where DAB2, an adaptor protein in the TGF-b pathway, formed a central node. Functional experiments confirmed that reducing Dab2 expression in renal tubules protected mice from Chronic kidney disease. | Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease.
Qiu C, Huang S, Park J, Park Y, Ko YA, Seasock MJ, Bryer JS, Xu XX, Song WC, Palmer M, Hill J, Guarnieri P, Hawkins J, Boustany-Kari CM, Pullen SS, Brown CD, Susztak K., Free PMC Article | 05/11/2019 |
| Estrogen-induced miR-191 was identified as a direct upstream regulator of DAB2 in ER-positive breast cancer cells. | miR-191/DAB2 axis regulates the tumorigenicity of estrogen receptor-positive breast cancer.
Tian X, Zhang Z. | 12/22/2018 |
| DAB2 is a frequent target of epigenetic silencing in oral carcinomas and may be potentially used for tumor detection | Frequent methylation of DAB2, a Wnt pathway antagonist, in oral and oropharyngeal squamous cell carcinomas.
Paluszczak J, Kiwerska K, Mielcarek-Kuchta D. | 09/1/2018 |
| Dab2 Ser723 phosphorylation is a key molecular event in thrombin-stimulated inside-out signaling and platelet activation, contributing to a new function of Dab2 in thrombin signaling. | Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets.
Tsai HJ, Chien KY, Liao HR, Shih MS, Lin YC, Chang YW, Cheng JC, Tseng CP. | 07/28/2018 |
| DAB2 might be involved in excessive aldosterone biosynthesis and correlate with specific clinical characteristics of aldosterone-producing adenoma patients. | Expression and Histopathological Significance of Disabled-2 in Aldosterone-Producing Adenoma.
Li P, Zhang M, Ma JQ, Sun Q, Liu GX, Zhao XZ, Feng WH, Shen SM, Guo HQ, Zhu DL. | 03/31/2018 |
| the results indicated that substrate stiffness could regulate EMT of cervical cancer cell lines HeLa and SiHa at least partially through miR-106b and its downstream target DAB2. | Substrate stiffness affects epithelial-mesenchymal transition of cervical cancer cells through miR-106b and its target protein DAB2.
Piao J, You K, Guo Y, Zhang Y, Li Z, Geng L. | 03/3/2018 |
| DAB2 can suppress the ERK signaling, but correlate to have TGF-beta-induced epithelial-to-mesenchymal transition (EMT) in esophageal squamous cell carcinomas (ESCCs). | Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma.
Wang WL, Chang WL, Yang HB, Wang YC, Chang IW, Lee CT, Chang CY, Lin JT, Sheu BS., Free PMC Article | 02/17/2018 |
| The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences. | Disabled-2: A modular scaffold protein with multifaceted functions in signaling.
Finkielstein CV, Capelluto DG. | 10/21/2017 |
| In conclusion, DAB2 and Intelectin-1 are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma | Identification of DAB2 and Intelectin-1 as Novel Positive Immunohistochemical Markers of Epithelioid Mesothelioma by Transcriptome Microarray Analysis for Its Differentiation From Pulmonary Adenocarcinoma.
Kuraoka M, Amatya VJ, Kushitani K, Mawas AS, Miyata Y, Okada M, Kishimoto T, Inai K, Nishisaka T, Sueda T, Takeshima Y. | 09/9/2017 |
| cathepsin B (CTSB) inhibition or expression of a CTSB-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta-treated cells from autophagy to apoptosis | Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.
Jiang Y, Woosley AN, Sivalingam N, Natarajan S, Howe PH., Free PMC Article | 06/10/2017 |
| abundances of megalin and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries | Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight.
Lybbert J, Gullingsrud J, Chesnokov O, Turyakira E, Dhorda M, Guerin PJ, Piola P, Muehlenbachs A, Oleinikov AV., Free PMC Article | 04/8/2017 |
| Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 which contributes to cell migration by targeting DAB2 in cervical carcinoma. | MicroRNA-106b is involved in transforming growth factor β1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma.
Cheng Y, Guo Y, Zhang Y, You K, Li Z, Geng L., Free PMC Article | 10/22/2016 |
| these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages | Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation.
Adamson SE, Griffiths R, Moravec R, Senthivinayagam S, Montgomery G, Chen W, Han J, Sharma PR, Mullins GR, Gorski SA, Cooper JA, Kadl A, Enfield K, Braciale TJ, Harris TE, Leitinger N., Free PMC Article | 08/20/2016 |
| inhibition of WNT/beta-catenin signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart. | Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling.
Hofsteen P, Robitaille AM, Chapman DP, Moon RT, Murry CE., Free PMC Article | 06/28/2016 |