| Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors. | Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors.
Suzuki H, Iwamoto H, Seki T, Nakamura T, Masuda A, Sakaue T, Tanaka T, Imamura Y, Niizeki T, Nakano M, Shimose S, Shirono T, Noda Y, Kamachi N, Sakai M, Morita K, Nakayama M, Yoshizumi T, Kuromatsu R, Yano H, Cao Y, Koga H, Torimura T., Free PMC Article | 08/11/2023 |
| IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis. | IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis.
Cai G, Qi Y, Wei P, Gao H, Xu C, Zhao Y, Qu X, Yao F, Yang W., Free PMC Article | 08/2/2023 |
| HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene. | HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene.
Cheng Y, Yang R, Zhou Y, Wang J, Zhang T, Wang S, Li H, Jiang W, Zhang X., Free PMC Article | 12/3/2022 |
| Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice. | Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
Ohde D, Walz M, Walz C, Noce A, Brenmoehl J, Langhammer M, Hoeflich A., Free PMC Article | 06/19/2021 |
| In inflamed experimental autoimmune encephalomyelitis (EAE) spinal cord, study found a significant increased number of IGF-I expressing neurons versus a reduced number of IGFBP-1 positive neurons. Moreover, while nearly all IGF-I neurons expressed GSK3beta, some expressed it more intensely. | Altered expression of IGF-I system in neurons of the inflamed spinal cord during acute experimental autoimmune encephalomyelitis.
Parvaneh Tafreshi A, Talebi F, Ghorbani S, Bernard C, Noorbakhsh F. | 04/21/2018 |
| the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss | A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wang X, Wei W, Krzeszinski JY, Wang Y, Wan Y., Free PMC Article | 09/10/2016 |
| Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha). | Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1.
Forsberg EA, Botusan IR, Wang J, Peters V, Ansurudeen I, Brismar K, Catrina SB. | 08/15/2015 |
| serum IGFBPI protein could provide an easily measured biomarker for early detection of alcohol-induced liver injury in humans | Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease.
Li HH, Doiron K, Patterson AD, Gonzalez FJ, Fornace AJ Jr., Free PMC Article | 09/27/2014 |
| During the two week starvation period, both the levels of plasma IGF-1 and IGFBP-1 decreased. | [Effects of compensatory growth on the levels of IGF-1, IGFBP-1 and expressions of IGF-1 mRNA, IGF-1R mRNA in Carassius auratus gibelio].
Shen WY, Ren G, Zhu YR. | 07/20/2013 |
| These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. | RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium.
Messmer-Blust AF, Philbrick MJ, Guo S, Wu J, He P, Guo S, Li J., Free PMC Article | 12/22/2012 |
| Global deletion of Igfbp1 in a c-Myc transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass. | Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model.
Gray A, Aronson WJ, Barnard RJ, Mehta H, Wan J, Said J, Cohen P, Galet C., Free PMC Article | 01/7/2012 |
| the embryopathic effects are associated with knockdown of EGNL1 and the associated induction of Igfbp1 mRNA in the placenta, but not the embryo. | Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta.
Ozolins TR, Fisher TS, Nadeau DM, Stock JL, Klein AS, Milici AJ, Morton D, Wilhelms MB, Brissette WH, Li B. | 01/21/2010 |
| Ahr regulates Igfbp-1 and Lpl expression in the liver. TCDD treatment did not increase the Igfbp-1 and Lpl mRNA levels in Ahr knockout mice. | Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor.
Minami K, Nakajima M, Fujiki Y, Katoh M, Gonzalez FJ, Yokoi T., Free PMC Article | 01/21/2010 |
| These data suggest that membrane dlk1 variants bind to extracellular IGFBP1/IGF-1 complexes, which may favor the release of IGF-1 and increase the local concentration of free IGF-1 that can enhance IGF receptor signaling, leading to adipogenesis. | dlk1 specifically interacts with insulin-like growth factor binding protein 1 to modulate adipogenesis of 3T3-L1 cells.
Nueda ML, García-Ramírez JJ, Laborda J, Baladrón V. | 01/21/2010 |
| When IGFBP1 is in a complex with BAK, formation of a proapoptotic p53/BAK complex and apoptosis induction are impaired, both in cultured cells and in liver. | Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria.
Leu JI, George DL., Free PMC Article | 01/21/2010 |
| IGFBP-1 may have an important regulatory role in vivo and in the pathogenesis of type 2 diabetes, in which loss of insulin release is an early pathogenetic event | Attenuation of insulin secretion by insulin-like growth factor binding protein-1 in pancreatic beta-cells.
Zhang F, Sjöholm Å, Zhang Q. | 01/21/2010 |
| the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors | The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors.
Degenhardt T, Matilainen M, Herzig KH, Dunlop TW, Carlberg C. | 01/21/2010 |
| Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. | Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR.
Averous J, Maurin AC, Bruhat A, Jousse C, Arliguie C, Fafournoux P. | 01/21/2010 |
| IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBP beta activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways. | Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation.
Leu JI, Crissey MA, Craig LE, Taub R., Free PMC Article | 01/21/2010 |
| high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model | Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction.
Watson CS, Bialek P, Anzo M, Khosravi J, Yee SP, Han VK. | 01/21/2010 |
| IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals | Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice.
Leu JI, Crissey MA, Taub R., Free PMC Article | 01/21/2010 |