| CYP26A1 Is a Novel Cancer Biomarker of Pancreatic Carcinoma: Evidence from Integration Analysis and In Vitro Experiments. | CYP26A1 Is a Novel Cancer Biomarker of Pancreatic Carcinoma: Evidence from Integration Analysis and In Vitro Experiments.
Yu Y, Wang Y, Zou Y, Yu Y., Free PMC Article | 06/25/2022 |
| A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface. | A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.
Wei DP, Li DD, Gu AQ, Ji WH, Yang Y, Peng JP., Free PMC Article | 09/25/2021 |
| Identification of a novel CYP26A1 mutation in a Chinese family with congenital microtia. | Identification of a novel CYP26A1 mutation in a Chinese family with congenital microtia.
Guo P, Ji Z, Jiang H, Huang X, Wang C, Pan B. | 08/14/2021 |
| Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy. | Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.
Gu AQ, Li DD, Wei DP, Liu YQ, Ji WH, Yang Y, Lin HY, Peng JP., Free PMC Article | 08/15/2020 |
| This review highlights the current knowledge of structure-function of CYP26 enzymes and focuses on their role in human retinoid metabolism in different tissues. | Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.
Isoherranen N, Zhong G., Free PMC Article | 08/1/2020 |
| The combined effects of the novel CYP26 single nucleotide polymorphisms -environment approach may predict the risk of occurrence of oral malignant disorders. | Application of simulation-based CYP26 SNP-environment barcodes for evaluating the occurrence of oral malignant disorders by odds ratio-based binary particle swarm optimization: A case-control study in the Taiwanese population.
Chen PH, Chuang LY, Wu KC, Wang YH, Shieh TY, Sheu JJ, Chang HW, Yang CH., Free PMC Article | 03/28/2020 |
| We applied whole-genome sequencing (WGS) on 9 trios where the probands are sporadically affected with the most severe form of the disorder and harbor no coding sequence variants affecting the function of known Hirschsprung disease (HSCR) genes. We found de novo protein-altering variants in three intolerant to change genes-CCT2, VASH1, and CYP26A1-for which a plausible link with the enteric nervous system (ENS) exists | Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing.
Tang CS, Zhuang X, Lam WY, Ngan ES, Hsu JS, Michelle YU, Man-Ting SO, Cherny SS, Ngo ND, Sham PC, Tam PK, Garcia-Barcelo MM., Free PMC Article | 02/23/2019 |
| Accumulating evidence suggest that cytochrome P450 (CYP26), the primary retinoid-inactivating enzyme, plays a critical role in the integration of two neoplastic molecular programs: the retinoid metabolism and Hedgehog pathways. (Review) | Retinoic acid, CYP26, and drug resistance in the stem cell niche.
Alonso S, Jones RJ, Ghiaur G., Free PMC Article | 10/7/2017 |
| CYP26A1 polymorphisms were associated with increased risk of malignant oral disorders in betel quid chewers. | Association study between novel CYP26 polymorphisms and the risk of betel quid-related malignant oral disorders.
Wu SJ, Chen YJ, Shieh TY, Chen CM, Wang YY, Lee KT, Lin YM, Chien PH, Chen PH., Free PMC Article | 07/30/2016 |
| CYP26A1-mediated oncogenic characteristics may be partially responsible for the elevated expression of fascin. | The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells.
Osanai M, Lee GH. | 03/26/2016 |
| Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents has been described. | Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents.
Sun B, Song S, Hao CZ, Huang WX, Liu CC, Xie HL, Lin B, Cheng MS, Zhao DM. | 10/3/2015 |
| data suggested that CYP26A1 overexpression might contribute to the development and progression of cervical malignancies and squamous neoplasia of the head and neck | Increased expression of the retinoic acid-metabolizing enzyme CYP26A1 during the progression of cervical squamous neoplasia and head and neck cancer.
Osanai M, Lee GH., Free PMC Article | 06/6/2015 |
| HNF4alpha coordinates with retinoic acid receptors in a retinoic acid-dependent manner to strongly induce CYP26A1 gene expression in the liver, which may explain the high level of response to retinoic acid observed in vivo. | Hepatocyte nuclear factor 4α (HNF4α) in coordination with retinoic acid receptors increases all-trans-retinoic acid-dependent CYP26A1 gene expression in HepG2 human hepatocytes.
Zolfaghari R, Ross AC., Free PMC Article | 05/16/2015 |
| In liver microsomes, CYP26A1 plays a role in clearing bioactive retinoids. | Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids.
Topletz AR, Tripathy S, Foti RS, Shimshoni JA, Nelson WL, Isoherranen N., Free PMC Article | 03/21/2015 |
| CYP26 is able to inactivate retinoids in serum, preventing retinoic acid signaling and thus bone-marrow hematopoietic stem cell differentiation. | Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling.
Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa JL, Gerber JM, Jones RJ., Free PMC Article | 12/7/2013 |
| The promoter region of CYP26A1 is significantly hypermethylated in allergic asthmatic subjects. | Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma.
Pascual M, Suzuki M, Isidoro-Garcia M, Padrón J, Turner T, Lorente F, Dávila I, Greally JM. | 10/6/2012 |
| Our observation suggests an involvement of enhanced CYP26A1 expression causing a functional vitamin A deficieny state in skin that can potentially lead to neoplastic transformation of keratinocytes in an early phase during skin carcinogenesis | Enhanced expression of retinoic acid-metabolizing enzyme CYP26A1 in sunlight-damaged human skin.
Osanai M, Lee GH. | 04/14/2012 |
| CYP26A1 and CYP26B1 are qualitatively similar retinoic acid hydroxylases with overlapping expression profiles; CYP26A1 has higher catalytic activity than CYP26B1. | Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.
Topletz AR, Thatcher JE, Zelter A, Lutz JD, Tay S, Nelson WL, Isoherranen N., Free PMC Article | 01/21/2012 |
| CYP26A1 and CYP26C1 play a pivotal role in the pathogenesis of nonsyndromic bilateral and unilateral optic nerve aplasia. | Nonsyndromic bilateral and unilateral optic nerve aplasia: first familial occurrence and potential implication of CYP26A1 and CYP26C1 genes.
Meire F, Delpierre I, Brachet C, Roulez F, Van Nechel C, Depasse F, Christophe C, Menten B, De Baere E., Free PMC Article | 12/10/2011 |
| Primary metabolites of all-trans-retinoic acid formed by CYP26A1 are identified and the ligand selectivity and ligand interactions of CYP26A1 are characterized. | Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase.
Thatcher JE, Buttrick B, Shaffer SA, Shimshoni JA, Goodlett DR, Nelson WL, Isoherranen N., Free PMC Article | 09/17/2011 |
| the functioning of multiple RAREs may account for the strong inducibility of CYP26A1 in liver, which, in turn, may be important physiologically for restoring retinoid homeostasis when the concentration of RA rises. | Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liver.
Zhang Y, Zolfaghari R, Ross AC., Free PMC Article | 08/30/2010 |
| CYP26A1 is expressed in human liver microsomes; its expression correlates with retinoic acid hydroxylation. | The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.
Thatcher JE, Zelter A, Isoherranen N., Free PMC Article | 08/16/2010 |
| cytochrome P450 family 26 (CYP26) enzymes have a role in determining the cellular exposure to retinoic acid by inactivating retinoic acid in cells that do not need retinoic acid--REVIEW | The role of CYP26 enzymes in retinoic acid clearance.
Thatcher JE, Isoherranen N., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (3) articlesCYP46A1 functional promoter haplotypes decipher genetic susceptibility to Alzheimer's disease.
Li Y, Chu LW, Wang B, Yik PY, Huriletemuer, Jin DY, Ma X, Song YQ. A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid.
El Kares R, Manolescu DC, Lakhal-Chaieb L, Montpetit A, Zhang Z, Bhat PV, Goodyer P. Positive association between ALDH1A2 and schizophrenia in the Chinese population.
Wan C, Shi Y, Zhao X, Tang W, Zhang M, Ji B, Zhu H, Xu Y, Li H, Feng G, He L. | 09/16/2009 |
| Variants in CYP26A1 are unlikely to be a major risk factor for caudal regression syndrome; further study with a larger number of genotyped subjects is required. | Mutational screening of the CYP26A1 gene in patients with caudal regression syndrome.
De Marco P, Merello E, Mascelli S, Raso A, Santamaria A, Ottaviano C, Calevo MG, Cama A, Capra V. | 01/21/2010 |