| Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression. | Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.
Xu Z, Qin Q, Wang Y, Zhang H, Liu S, Li X, Chen Y, Wang Y, Ruan H, He W, Zhang T, Yan X, Wang C, Xu D, Jiang X., Free PMC Article | 02/16/2024 |
| Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p. | Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
Hayashi Y, Kimura S, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hatakeyama Y, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T. | 01/11/2023 |
| miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4. | miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4.
Tang H, Zhu W, Cao L, Zhang J, Li J, Ma D, Guo C., Free PMC Article | 10/29/2022 |
| DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation. | DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
Tiane A, Schepers M, Riemens R, Rombaut B, Vandormael P, Somers V, Prickaerts J, Hellings N, van den Hove D, Vanmierlo T., Free PMC Article | 11/13/2021 |
| Targeted Disruption of the Inhibitor of DNA Binding 4 (Id4) Gene Alters Photic Entrainment of the Circadian Clock. | Targeted Disruption of the Inhibitor of DNA Binding 4 (Id4) Gene Alters Photic Entrainment of the Circadian Clock.
Duffield GE, Robles-Murguia M, Hou TY, McDonald KA., Free PMC Article | 10/30/2021 |
| Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus. | Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus.
Zhang R, Boareto M, Engler A, Louvi A, Giachino C, Iber D, Taylor V. | 09/12/2020 |
| Id4 is a transcriptional regulator critically involved in the differentiation of OPN-type osteoblasts. JNK-Id4 signaling axis is crucial in the control of OPN and OCN expression during osteoblastic differentiation. | JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4).
Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T. | 05/23/2020 |
| Id4 and other Id proteins promote elimination of Ascl1 protein in neural stem cells culture. Id4 sequesters Ascl1 heterodimerization partner E47, promoting Ascl1 protein degradation and stem cell quiescence. | Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells.
Blomfield IM, Rocamonde B, Masdeu MDM, Mulugeta E, Vaga S, van den Berg DL, Huillard E, Guillemot F, Urbán N., Free PMC Article | 04/4/2020 |
| BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction. | BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction.
Kusuyama J, Seong C, Nakamura T, Ohnishi T, Amir MS, Shima K, Semba I, Noguchi K, Matsuguchi T. | 03/21/2020 |
| ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states | ID4 levels dictate the stem cell state in mouse spermatogonia.
Helsel AR, Yang QE, Oatley MJ, Lord T, Sablitzky F, Oatley JM., Free PMC Article | 09/23/2017 |
| results indicate that Id4 marks spermatogonial stem cells in the mouse testis. | Id4 Marks Spermatogonial Stem Cells in the Mouse Testis.
Sun F, Xu Q, Zhao D, Degui Chen C., Free PMC Article | 10/1/2016 |
| ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation. | ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.
Junankar S, Baker LA, Roden DL, Nair R, Elsworth B, Gallego-Ortega D, Lacaze P, Cazet A, Nikolic I, Teo WS, Yang J, McFarland A, Harvey K, Naylor MJ, Lakhani SR, Simpson PT, Raghavendra A, Saunus J, Madore J, Kaplan W, Ormandy C, Millar EK, O'Toole S, Yun K, Swarbrick A. | 03/26/2016 |
| Id4 regulates NKX3.1, Sox9 and PTEN. | Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.
Sharma P, Knowell AE, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, Havrda MC, Chaudhary J., Free PMC Article | 04/4/2015 |
| Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary | Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary.
Best SA, Hutt KJ, Fu NY, Vaillant F, Liew SH, Hartley L, Scott CL, Lindeman GJ, Visvader JE. | 10/18/2014 |
| High expression levels of Id1-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation. | The expression and roles of inhibitor of DNA binding helix-loop-helix proteins in the developing and adult mouse retina.
Du Y, Yip HK. | 06/2/2012 |
| CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell | Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.
Huang J, Vogel G, Yu Z, Almazan G, Richard S., Free PMC Article | 03/3/2012 |
| ID4 promotes mammary gland development by suppressing p38MAPK activity. | ID4 regulates mammary gland development by suppressing p38MAPK activity.
Dong J, Huang S, Caikovski M, Ji S, McGrath A, Custorio MG, Creighton CJ, Maliakkal P, Bogoslovskaia E, Du Z, Zhang X, Lewis MT, Sablitzky F, Brisken C, Li Y., Free PMC Article | 01/7/2012 |
| Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis. | Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL.
Chen SS, Claus R, Lucas DM, Yu L, Qian J, Ruppert AS, West DA, Williams KE, Johnson AJ, Sablitzky F, Plass C, Byrd JC., Free PMC Article | 04/16/2011 |
| Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types. | Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.
Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, Bono H, Ninomiya Y, Kanesaki-Yatsuka Y, Akita M, Motegi H, Wakana S, Noda T, Sablitzky F, Arai S, Kurokawa R, Fukuda T, Katagiri T, Schönbach C, Suda T, Mizuno Y, Okazaki Y., Free PMC Article | 11/27/2010 |
| ID4 has a role in adipocyte differentiation and the implications of this regulation for adipose tissue formation | Inhibitor of DNA binding 4 (ID4) regulation of adipocyte differentiation and adipose tissue formation in mice.
Murad JM, Place CS, Ran C, Hekmatyar SK, Watson NP, Kauppinen RA, Israel MA., Free PMC Article | 09/20/2010 |
| ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa. | Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.
Borinstein SC, Conerly M, Dzieciatkowski S, Biswas S, Washington MK, Trobridge P, Henikoff S, Grady WM., Free PMC Article | 02/8/2010 |
| Id4 has a unique and complex function in regulating neural stem cell proliferation and differentiation | Id4 regulates neural progenitor proliferation and differentiation in vivo.
Yun K, Mantani A, Garel S, Rubenstein J, Israel MA. | 01/21/2010 |
| ID proteins (ID1, ID2, ID3 and ID4) were significantly increased in Mecp2-deficient Rett syndrome brain; ID genes are ideal targets for MeCP2 regulation of neuronal maturation that may explain the molecular pathogenesis of Rett syndrome | Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome.
Peddada S, Yasui DH, LaSalle JM., Free PMC Article | 01/21/2010 |
| these data support the role of Id4 as oligodendrocyte differentiation inhibitor | Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings.
Marin-Husstege M, He Y, Li J, Kondo T, Sablitzky F, Casaccia-Bonnefil P. | 01/21/2010 |
| Id4 has a critical role in regulating neural precursor cell proliferation and differentiation | Id4 is required for the correct timing of neural differentiation.
Bedford L, Walker R, Kondo T, van Crüchten I, King ER, Sablitzky F. | 01/21/2010 |