| Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene. | Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.
Cardoso M, Maia S, Brandão A, Sahasrabudhe R, Lott P, Belter N, Carvajal-Carmona LG, Paulo P, Teixeira MR., Free PMC Article | 03/16/2023 |
| FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer. | FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer.
Li T, Huang S, Yan W, Zhang Y, Guo Q., Free PMC Article | 08/27/2022 |
| The programmed expression of full-length BMCC1 in human neuroblastoma cells undergoing DNA damage-induced apoptosis. | Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.
Islam MS, Takano R, Yokochi T, Akter J, Nakamura Y, Nakagawara A, Tatsumi Y., Free PMC Article | 12/14/2019 |
| E2F1 directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma. | Transcriptional regulation of BMCC1 mediated by E2F1 in neuroblastoma cells.
Islam MS, Tatsumi Y, Takano R, Yokochi T, Akter J, Ozaki T, Nakamura Y, Ohira M, Nakagawara A. | 06/3/2017 |
| Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer. | PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.
Salameh A, Lee AK, Cardó-Vila M, Nunes DN, Efstathiou E, Staquicini FI, Dobroff AS, Marchiò S, Navone NM, Hosoya H, Lauer RC, Wen S, Salmeron CC, Hoang A, Newsham I, Lima LA, Carraro DM, Oliviero S, Kolonin MG, Sidman RL, Do KA, Troncoso P, Logothetis CJ, Brentani RR, Calin GA, Cavenee WK, Dias-Neto E, Pasqualini R, Arap W., Free PMC Article | 10/31/2015 |
| BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2. | BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis.
Tatsumi Y, Takano R, Islam MS, Yokochi T, Itami M, Nakamura Y, Nakagawara A., Free PMC Article | 09/12/2015 |
| recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found. | Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.
Yu W, McPherson JR, Stevenson M, van Eijk R, Heng HL, Newey P, Gan A, Ruano D, Huang D, Poon SL, Ong CK, van Wezel T, Cavaco B, Rozen SG, Tan P, Teh BT, Thakker RV, Morreau H. | 04/18/2015 |
| BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. | BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
Harris JL, Richards RS, Chow CW, Lee S, Kim M, Buck M, Teng L, Clarke R, Gardiner RA, Lavin MF., Free PMC Article | 06/21/2014 |
| We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex. | Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
Li S, Hayakawa-Yano Y, Itoh M, Ueda M, Ohta K, Suzuki Y, Mizuno A, Ohta E, Hida Y, Wang MX, Nakagawa T. | 05/4/2013 |
| PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma. | [Expression of PRUNE2 mRNA and its positive correlation with non-coding RNA PCA3 in leiomyosarcoma].
Yang JL, Cogdell D, Eddy J, Trent J, Price N, Zhang W. | 04/6/2013 |
| The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems. | Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues.
Iwama E, Tsuchimoto D, Iyama T, Sakumi K, Nakagawara A, Takayama K, Nakanishi Y, Nakabeppu Y. | 09/3/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. | 12/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The androgen regulation of PRUNE2 expression in prostate cancer cells was found to not be of any diagnostic value. | Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer.
Salagierski M, Verhaegh GW, Jannink SA, Smit FP, Hessels D, Schalken JA. | 01/21/2010 |
| the longer BMCC1-1 isoform is upregulated in PCa tissues and metastases | New genomic structure for prostate cancer specific gene PCA3 within BMCC1: implications for prostate cancer detection and progression.
Clarke RA, Zhao Z, Guo AY, Roper K, Teng L, Fang ZM, Samaratunga H, Lavin MF, Gardiner RA., Free PMC Article | 01/21/2010 |
| Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. | Cleavage of BNIP-2 and BNIP-XL by caspases.
Valencia CA, Cotten SW, Liu R. | 01/21/2010 |
| findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation | BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain.
Soh UJ, Low BC. | 01/21/2010 |
| BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells | Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas.
Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A. | 01/21/2010 |
| OBSCN and C9orf65 comprise a highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas. | Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.
Price ND, Trent J, El-Naggar AK, Cogdell D, Taylor E, Hunt KK, Pollock RE, Hood L, Shmulevich I, Zhang W., Free PMC Article | 01/21/2010 |