| The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis. | The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis.
Huang Z, Jiang Y, Zhou Y., Free PMC Article | 05/15/2021 |
| CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROSinduced lipid peroxidation and inflammation. | CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation.
Gao H, Cao Y, Xia H, Zhu X, Jin Y., Free PMC Article | 12/5/2020 |
| Mutation in CYP4A11 gene is associated with cetuximab resistance in colorectal cancer. | New genetic variations discovered in KRAS wild-type cetuximab resistant chinese colorectal cancer patients.
Jing C, Wang T, Ma R, Cao H, Wang Z, Liu S, Chen D, Zhang J, Wu Y, Zhang Y, Wu J, Feng J. | 07/11/2020 |
| The rs1126742 T/C polymorphism of CYP4A11 is more likely to be a genetic risk factor for the hypertension cases in the Caucasian population. Moreover, whereas the AG genotype of CYP4A11 rs9332978 may be associated with an increased risk of hypertension, the AA genotype of rs9333025 may be linked to a decreased risk of cardiovascular and cerebrovascular diseases. [meta-analysis] | Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases.
Yu K, Zhang T, Li X. | 07/20/2019 |
| Haplotype G-C-A of CYP4A11 was associated with increased risk of coronary artery disease. | A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease.
Sirotina S, Ponomarenko I, Kharchenko A, Bykanova M, Bocharova A, Vagaytseva K, Stepanov V, Churnosov M, Solodilova M, Polonikov A., Free PMC Article | 09/8/2018 |
| Gene-gene interaction between rs1126742 and rs3890011 and gene-environment interaction between rs1126742 and smoking were associated with increased EH risk. | Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population.
Zhang H, Jin L, Mu T, Fan Y, Zhang H, Zhu Y, Mao X, Li R, Tang S. | 03/17/2018 |
| The DEGs, such as AGTR1, CYP3A4 and CYP4A11 may play critical roles in the development of HTN likely via the regulation by hsa-miR-26b-5p and taking part in some pathways. | Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile.
Chen Z, Wu H, Wang G, Feng Y., Free PMC Article | 12/2/2017 |
| Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. | Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP., Free PMC Article | 07/15/2017 |
| These results point to a potential 20-HETE dependence of intrarenal angiotensinogen production and ANGII receptor type 1 activation that are associated with increases in NCC and SGK1 and identify elevated P450 4A11 activity and 20-HETE as potential risk factors for salt-sensitive human hypertension by perturbation of the renal renin-angiotensin axis. | 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
Savas Ü, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF., Free PMC Article | 05/6/2017 |
| CYP4A11 Variants are associated with Ischemic Stroke. | Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke.
Yi X, Wu L, Liao D, Wang C, Zhang B., Free PMC Article | 04/8/2017 |
| The results suggest that individuals carrying the alleles, K276T and S353G, might exhibit higher catalysis of CYP4A11 | Biochemical analysis of recombinant CYP4A11 allelic variant enzymes: W126R, K276T and S353G.
Han S, Cha GS, Chun YJ, Lee CH, Kim D, Yun CH. | 03/18/2017 |
| CYP4A1l rs9333025 GG and CYP4F2 rs2108622 GG two-loci interaction significantly increases the risk for IS and an elevated 20-HETE level. | Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level.
Liao D, Yi X, Zhang B, Zhou Q, Lin J., Free PMC Article | 03/4/2017 |
| Single nucleotide polymorphism of CYP4A11 gene is associated with Plaque in Patients with Ischemic Stroke. | Cytochrome P450 Genetic Variants and Their Metabolite Levels Associated with Plaque Stability in Patients with Ischemic Stroke.
Yi XY, Liao DX, Wang C, Cheng W, Fu XQ, Zhang B. | 12/17/2016 |
| Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke. | Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations.
Yi X, Liao D, Fu X, Zhang B, Wang C. | 08/27/2016 |
| The present study focused on 10 CYP4A11 variant alleles and evaluated their functional characteristics using arachidonic acid as the substrate in a COS-7 cell-based expression system. | Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation.
Saito T, Honda M, Takahashi M, Tsukada C, Ito M, Katono Y, Hosono H, Saigusa D, Suzuki N, Tomioka Y, Hirasawa N, Hiratsuka M. | 03/26/2016 |
| To evaluate the associations between four single-nucleotide polymorphisms (SNPs) in CYP4A11 and CYP4F2 and ischemic stroke (IS) | Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese.
Zhang B, Yi X, Wang C, Liao D, Lin J, Chi L., Free PMC Article | 03/26/2016 |
| The CC genotype and C allele of the CYP4A11 gene were associated with essential hypertension in the male western Chinese Han population. | CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population.
Yang H, Fu Z, Ma Y, Huang D, Zhu Q, Erdenbat C, Xie X, Liu F, Zheng Y. | 07/25/2015 |
| individuals homozygous for the CYP4A11 rs3890011 C allele, blood pressure is resistant to mineralocorticoid receptor antagonism, but sensitive to ENaC inhibition, consistent with ENaC activation. | Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans.
Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ., Free PMC Article | 04/25/2015 |
| Results indicate that both the transfer of an electron to the ferrous.O2 complex and C-H bond-breaking limit the rate of CYP4A11 ( cytochrome P450 4A11) omega-oxidation. | Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11.
Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP., Free PMC Article | 04/25/2015 |
| This meta-analysis suggests the CYP4A11 T8590C polymorphism may be a risk factor for hypertension. | T8590C polymorphism of CYP4A11 is a risk factor for hypertension: a meta-analysis.
Jiang Y, Hou J, Zhang Q, Tang W, Luo Y. | 04/11/2015 |
| suggests there is a significant association between the CYP4A11 T8590C variant and essential hypertension, especially in Caucasians. The case-control study did not find a significant association among the Han Chinese population | Association between the CYP4A11 T8590C variant and essential hypertension: new data from Han Chinese and a meta-analysis.
Yan HC, Liu JH, Li J, He BX, Yang L, Qiu J, Li L, Ding DP, Shi L, Zhao SJ., Free PMC Article | 09/27/2014 |
| The results suggest that the CYP4A11 GG genotype was a high risk factor for hypertension. | Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China.
Liang JQ, Yan MR, Yang L, Suyila Q, Cui HW, Su XL. | 09/27/2014 |
| This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. | Genetic associations with hypertension: meta-analyses of six candidate genetic variants.
Zhang C, Wang L, Liao Q, Zhang L, Xu L, Chen C, Ye H, Xu X, Ye M, Duan S., Free PMC Article | 04/19/2014 |
| The CYP4A11 8590C allele was also associated with low HDL-C in women. | CYP4A11 variant is associated with high-density lipoprotein cholesterol in women.
White CC, Feng Q, Cupples LA, Gainer JV, Dawson EP, Wilke RA, Brown NJ., Free PMC Article | 10/26/2013 |
| rs3890011 maybe a novel polymorphism of the CYP4A11 gene associated with CAD in a Han Chinese population. | A novel polymorphism of the CYP4A11 gene is associated with coronary artery disease.
Fu Z, Ma Y, Xie X, Huang D, Yang H, Nakayama T, Sato N. | 07/13/2013 |