| Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition in spinal cord gliomas via PI3K/AKT pathway. | Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition in spinal cord gliomas via PI3K/AKT pathway.
Zhao Z, Song Z, Wang Z, Zhang F, Ding Z, Zhao Z, Liu L, Fan T., Free PMC Article | 09/5/2024 |
| Retinol dehydrogenase 10 contributes to cancer stemness and intracellular carbohydrate storage in ovarian clear cell carcinomas. | Retinol dehydrogenase 10 contributes to cancer stemness and intracellular carbohydrate storage in ovarian clear cell carcinomas.
Murakami A, Amano T, Yoshino F, Kita H, Moritani S, Murakami T, Chano T. | 08/6/2022 |
| Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes. | Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
Klyuyeva AV, Belyaeva OV, Goggans KR, Krezel W, Popov KM, Kedishvili NY., Free PMC Article | 08/28/2021 |
| RDH10 regulated the migration and invasion of glioma cells via the TGF-beta/SMAD signaling pathway. | Retinol dehydrogenase 10 promotes metastasis of glioma cells via the transforming growth factor-β/SMAD signaling pathway.
Guan F, Kang Z, Wang L, Wang K, Mao BB, Peng WC, Zhang BL, Lin ZY, Zhang JT, Hu ZQ., Free PMC Article | 04/11/2020 |
| increased expression of ALDH1A1-RDH10-RARalpha- PPARbeta/delta pattern could be considered as adverse prognostic factor associated with a higher concentration of paraprotein and worst overall survival of patients with newly diagnosed multiple myeloma. | [[Gene expression of key enzymes for all-trans- retinoic acid biosynthesis - ALDHJAI and RDH10: relationship with co-expression of nuclear receptors RARα and PPARβ/δ genes and some clinical characteristics in multiple myeloma].
Kalitin NN, Chernykh YB, Buravtsova IV. | 02/23/2019 |
| In close proximity to RDH10 gene on human chromosome 8 are located two genes that are phylogenetically related to RDH10. The predicted protein products of these genes, retinol dehydrogenase epidermal 2 (RDHE2, SDR16C5) and retinol dehydrogenase epidermal 2-similar (RDHE2S, SDR16C6), share 59% and 56% sequence similarity with RDH10. | Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.
Adams MK, Lee SA, Belyaeva OV, Wu L, Kedishvili NY., Free PMC Article | 12/2/2017 |
| the bifunctional nature of retinoid oxidoreductase complex provides the RA-based signaling system with robustness by safeguarding appropriate RA concentration despite naturally occurring fluctuations in RDH10 and DHRS3. | The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.
Belyaeva OV, Adams MK, Wu L, Kedishvili NY., Free PMC Article | 06/3/2017 |
| Taken together, our findings demonstrate that RDH10 is essential during the early stages of facial morphogenesis for the formation of a functional nasal airway, and furthermore establish Rdh10 mutant mice as an important model system to study choanal atresia (CA) . | Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.
Kurosaka H, Wang Q, Sandell L, Yamashiro T, Trainor PA., Free PMC Article | 05/20/2017 |
| Insulin inhibits retinoic acid biosynthesis through inhibition of FoxO1-induced Rdh10 gene expression. | Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.
Obrochta KM, Krois CR, Campos B, Napoli JL., Free PMC Article | 05/30/2015 |
| Data indicate that retinaldehyde reductase (DHRS3) requires retinol dehydrogenase 10 (RDH10) for full enzymatic activity and, in turn, activates RDH10. | The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.
Adams MK, Belyaeva OV, Wu L, Kedishvili NY., Free PMC Article | 11/8/2014 |
| all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma | RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells.
Gyöngyösi A, Szatmari I, Pap A, Dezso B, Pos Z, Széles L, Varga T, Nagy L., Free PMC Article | 04/26/2014 |
| Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture. | Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture.
Lee SA, Belyaeva OV, Wu L, Kedishvili NY., Free PMC Article | 07/2/2011 |
| CYP4Z1, KIR and RDH10 could play a role in non-small-cell lung cancer progression | Identification of genes associated with non-small-cell lung cancer promotion and progression.
Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, Tanic N. | 04/12/2010 |
| wild-type RDH10 catalysed both oxidation of all-trans-retinol and reduction of all-trans-retinal in a cofactor-dependent manner In vitro, however, oxidation is the favoured reaction catalysed by RDH10 | Characterization of key residues and membrane association domains in retinol dehydrogenase 10.
Takahashi Y, Moiseyev G, Farjo K, Ma JX., Free PMC Article | 01/21/2010 |
| dual physiological role for RDH10: in the biosynthesis of 11-cis-retinaldehyde for vision as well as the biosynthesis of all-trans-retinoic acid for differentiation and development | Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase.
Belyaeva OV, Johnson MP, Kedishvili NY., Free PMC Article | 01/21/2010 |
| Forced over-expression of the RDH10 gene causes growth arrest of HepG2 cells and could be a possible curative strategy for hepatocellular carcinoma. | Forced expression of RDH10 gene retards growth of HepG2 cells.
Rossi E, Picozzi P, Bodega B, Lavazza C, Carlo-Stella C, Marozzi A, Ginelli E. | 01/21/2010 |
| organization of the gene includes a unique transcriptional start site, a coding region with six translated exons and a 3' UTR containing at least two used polyadenylation sites. | Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene.
Picozzi P, Marozzi A, Fornasari D, Benfante R, Barisani D, Meneveri R, Ginelli E. | 01/21/2010 |