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    PEBP4 phosphatidylethanolamine binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 157310, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Overexpression of phosphatidylethanolamine-binding protein 4 (PEBP4) associates with recurrence of meningiomas.

    Overexpression of phosphatidylethanolamine-binding protein 4 (PEBP4) associates with recurrence of meningiomas.
    Huang RQ, Chen F, Jiang YB, Jin YM, Wang SQ, Liang HH, Chen ZP, Qian J.

    04/23/2022
    Diagnostic value of phosphatidylethanolamine binding protein 4 levels in patients receiving nursing interventions for advanced chronic kidney disease.

    Diagnostic value of phosphatidylethanolamine binding protein 4 levels in patients receiving nursing interventions for advanced chronic kidney disease.
    He P, Zhou C, Shen H., Free PMC Article

    08/28/2021
    PEBP4 colocalised with IgA and CD19.

    Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys.
    Taylor S, Pieri K, Nanni P, Tica J, Barratt J, Didangelos A.

    08/1/2020
    these results suggest that PEBP4 may promote tumorigenesis in non-small cell lung cancer by regulating cell proliferation and epithelial-to-mesenchymal transition via activation of the Shh signaling pathway.

    Phosphatidylethanolamine-binding protein 4 promotes the epithelial-to-mesenchymal transition in non-small cell lung cancer cells by activating the sonic hedgehog signaling pathway.
    Jian W, Bai Y, Li X, Kang J, Lei Y, Xue Y.

    07/18/2020
    High PEBP4 expression is associated with glioma cell growth and invasiveness.

    Knockdown of PEBP4 inhibits human glioma cell growth and invasive potential via ERK1/2 signaling pathway.
    Huang RQ, Wang SQ, Zhu QB, Guo SC, Shi DL, Chen F, Fang YC, Chen R, Lu YC.

    07/6/2019
    PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway

    Role of the PEBP4 protein in the development and metastasis of gastric cancer.
    Wu Z, Liu B, Zheng X, Hou H, Li Y., Free PMC Article

    09/23/2017
    knockdown of PEBP4 inhibited hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells.

    PEBP4 silencing inhibits hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells.
    Li W, Dong Y, Zhang B, Kang Y, Yang X, Wang H.

    01/28/2017
    this study suggested that PEBP4 might promote the progression of pancreatic ductal adenocarcinoma

    PEBP4 promoted the growth and migration of cancer cells in pancreatic ductal adenocarcinoma.
    Zhang D, Dai Y, Cai Y, Suo T, Liu H, Wang Y, Cheng Z, Liu H.

    01/28/2017
    Increased expression of phosphatidylethanolamine-binding protein 4 strongly associates with gliomas grade.

    Increased expression of phosphatidylethanolamine-binding protein 4 (PEBP4) strongly associates with human gliomas grade.
    Huang RQ, Shi DL, Huang W, Chen F, Lu YC.

    12/17/2016
    PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation.

    Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions.
    He H, Liu D, Lin H, Jiang S, Ying Y, Chun S, Deng H, Zaia J, Wen R, Luo Z., Free PMC Article

    09/10/2016
    Increased miR-15b expression in lung adenocarcinoma patients treated with cisplatin-based chemotherapy was correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis.

    miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells.
    Zhao Z, Zhang L, Yao Q, Tao Z.

    01/16/2016
    overexpression of PEBP4, which we show to be a target of miR-34a, reduces the sensitivity of lung cancer cells to cisplatin

    Downregulation of PEBP4, a target of miR-34a, sensitizes drug-resistant lung cancer cells.
    Yu G, Zhong N, Chen G, Huang B, Wu S.

    01/10/2015
    in human breast cancer hPEBP4 is a novel and clinically relevant metastasis accelerator gene

    Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation.
    Li H, Huang F, Fan L, Jiang Y, Wang X, Li J, Wang Q, Pan H, Sun J, Cao X, Wang X.

    11/22/2014
    Human PEBP4 expression correlates negatively with estrogen and progesterone receptors in endometrial carcinoma.

    Expression of hPEBP4 negatively correlates with estrogen and progesterone receptors in endometrial carcinoma.
    Guo T, Li B, Gu C.

    11/23/2013
    hPEBP4 knockdown potentiated the chemosensitization of the rituximab in B-cell lymphoma cells by regulating the expression of Bcl-xl, Cycline E, p21(waf/cip1) and p53 and the activation of caspase-3 and caspase-9.

    Silencing of human phosphatidylethanolamine-binding protein 4 enhances rituximab-induced death and chemosensitization in B-cell lymphoma.
    Wang K, Jiang Y, Zheng W, Liu Z, Li H, Lou J, Gu M, Wang X., Free PMC Article

    09/7/2013
    the independent predictive values of hPEBP4 in response of rectal cancer to preoperative radiotherapy, are reported.

    hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy.
    Qiu J, Yang G, Shen Z, Xie Y, Wang L.

    08/10/2013
    PEBP4 enhanced cell proliferation and invasion ability and inhibited apoptosis. Decreased PEBP4 expression may play a role in the reduced invasion ability and increased apoptosis of the human non-small cell lung cancer cell line HCC827.

    PEBP4 enhanced HCC827 cell proliferation and invasion ability and inhibited apoptosis.
    Yu G, Shen Z, Chen G, Teng X, Hu Y, Huang B.

    03/30/2013
    The over-expression of PEBP4 protein may be related to the tumorigenesis, development, metastasis, and invasion of colorectal cancer.

    Expression of PEBP4 protein correlates with the invasion and metastasis of colorectal cancer.
    Liu H, Kong Q, Li B, He Y, Li P, Jia B.

    02/11/2012
    PEBP4 over-expression may promote the invasion and metastasis of non-small cell lung cancer.

    PEBP4 gene expression and its significance in invasion and metastasis of non-small cell lung cancer.
    Yu GP, Huang B, Chen GQ, Wu S, Ji Y, Shen ZY.

    02/11/2012
    Data show that PEBP4 protein overexpression was associated with the occurrence, invasion, and metastasis of lung squamous cell carcinoma.

    The expression of PEBP4 protein in lung squamous cell carcinoma.
    Yu GP, Chen GQ, Wu S, Shen K, Ji Y.

    02/4/2012
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
    Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C., Free PMC Article

    12/2/2009
    Data show that PEBP4 participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK.

    Regulation of human myoblast differentiation by PEBP4.
    Garcia R, Grindlay J, Rath O, Fee F, Kolch W., Free PMC Article

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C.

    04/1/2009
    Silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer.

    Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways.
    Li P, Wang X, Li N, Kong H, Guo Z, Liu S, Cao X.

    01/21/2010
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