| GRK2-YAP signaling is implicated in pulmonary arterial hypertension development. | GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.
Ye P, Deng Y, Gu Y, Liu P, Luo J, Pu J, Chen J, Huang Y, Wang N, Ji Y, Chen S., Free PMC Article | 04/10/2024 |
| Exploring the potential biological function of GRK2 in colorectal cancer. | Exploring the potential biological function of GRK2 in colorectal cancer.
Gao M, Liang X, Fan M, Wu Y, Dong MY, Du RL. | 03/7/2024 |
| G Protein-Coupled Receptor Kinase 2 Selectively Enhances beta-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation. | G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D(2) Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation.
Sánchez-Soto M, Boldizsar NM, Schardien KA, Madaras NS, Willette BKA, Inbody LR, Dasaro C, Moritz AE, Drube J, Haider RS, Free RB, Hoffman C, Sibley DR., Free PMC Article | 11/2/2023 |
| CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration. | CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration.
Zhang J, Zhang X, Shi X, Liu Y, Cheng D, Tian Q, Lin N, Wei W, Wu H. | 05/18/2023 |
| Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen. | Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen.
Fu L, Adu-Amankwaah J, Sang L, Tang Z, Gong Z, Zhang X, Li T, Sun H. | 02/25/2023 |
| Targeted inhibition of the GRK2/HIF-1alpha pathway is an effective strategy to alleviate synovial hypoxia and inflammation. | Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia and inflammation.
Hong Z, Tie Q, Zhang L. | 12/17/2022 |
| GRK2 in cardiovascular disease and its potential as a therapeutic target. | GRK2 in cardiovascular disease and its potential as a therapeutic target.
Ferrero KM, Koch WJ. | 11/19/2022 |
| The tyrosine phosphorylation of GRK2 is responsible for activated D2R-mediated insulin resistance. | The tyrosine phosphorylation of GRK2 is responsible for activated D(2)R-mediated insulin resistance.
Gao Z, Min X, Kim KM, Liu H, Hu L, Wu C, Zhang X. | 10/15/2022 |
| GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by beta-arrestin recruiting GPR84 agonists. | GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists.
Fredriksson J, Holdfeldt A, Mårtensson J, Björkman L, Møller TC, Müllers E, Dahlgren C, Sundqvist M, Forsman H. | 04/16/2022 |
| Mdm2-Mediated Downmodulation of GRK2 Restricts Centrosome Separation for Proper Chromosome Congression. | Mdm2-Mediated Downmodulation of GRK2 Restricts Centrosome Separation for Proper Chromosome Congression.
Reglero C, Ortiz Del Castillo B, Rivas V, Mayor F Jr, Penela P., Free PMC Article | 10/23/2021 |
| The Open Question of How GPCRs Interact with GPCR Kinases (GRKs). | The Open Question of How GPCRs Interact with GPCR Kinases (GRKs).
Cato MC, Yen YC, Francis CJ, Elkins KE, Shareef A, Sterne-Marr R, Tesmer JJG., Free PMC Article | 09/25/2021 |
| Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. | Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.
Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ, University of Washington Center for Mendelian Genomics, Rohatgi R, Cohn DH, Krakow D, Krejci P., Free PMC Article | 09/4/2021 |
| The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14. | The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14.
Kim D, Castaño M, Lujan LK, Woo JA, Liggett SB., Free PMC Article | 08/28/2021 |
| The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions. | The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions.
Sorriento D, Rusciano MR, Visco V, Fiordelisi A, Cerasuolo FA, Poggio P, Ciccarelli M, Iaccarino G., Free PMC Article | 07/10/2021 |
| GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure. | GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.
Laudette M, Formoso K, Lezoualc'h F., Free PMC Article | 06/26/2021 |
| Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth. | Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth.
Crudden C, Shibano T, Song D, Dragomir MP, Cismas S, Serly J, Nedelcu D, Fuentes-Mattei E, Tica A, Calin GA, Girnita A, Girnita L. | 05/8/2021 |
| The PDZ Domain Protein SYNJ2BP Regulates GRK-Dependent Sst2A Phosphorylation and Downstream MAPK Signaling. | The PDZ Domain Protein SYNJ2BP Regulates GRK-Dependent Sst2A Phosphorylation and Downstream MAPK Signaling.
Carr HS, Chang JT, Frost JA., Free PMC Article | 05/1/2021 |
| Angiotensin II Type 2 Receptor Modulates Synovial Macrophage Polarization by Inhibiting GRK2 Membrane Translocation in a Rat Model of Collagen-Induced Arthritis. | Angiotensin II Type 2 Receptor Modulates Synovial Macrophage Polarization by Inhibiting GRK2 Membrane Translocation in a Rat Model of Collagen-Induced Arthritis.
Wang X, Tu J, Jiang J, Zhang Q, Liu Q, Körner H, Wu J, Wu H, Wei W. | 04/17/2021 |
| Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. | Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells.
Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M., Free PMC Article | 04/13/2021 |
| Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and beta-Arrestins as Targets. | Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and β-Arrestins as Targets.
Kayki-Mutlu G, Koch WJ., Free PMC Article | 04/3/2021 |
| G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas. | G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas.
Palacios-García J, Sanz-Flores M, Asensio A, Alvarado R, Rojo-Berciano S, Stamatakis K, Paramio JM, Cano A, Nieto MÁ, García-Escudero R, Mayor F Jr, Ribas C. | 03/27/2021 |
| GRK2-mediated receptor phosphorylation and Mdm2-mediated beta-arrestin2 ubiquitination drive clathrin-mediated endocytosis of G protein-coupled receptors. | GRK2-mediated receptor phosphorylation and Mdm2-mediated β-arrestin2 ubiquitination drive clathrin-mediated endocytosis of G protein-coupled receptors.
Zhang X, Zheng M, Kim KM. | 03/20/2021 |
| Dissecting the roles of GRK2 and GRK3 in mu-opioid receptor internalization and beta-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells. | Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.
Møller TC, Pedersen MF, van Senten JR, Seiersen SD, Mathiesen JM, Bouvier M, Bräuner-Osborne H., Free PMC Article | 03/13/2021 |
| GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis. | GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis.
Pathania AS, Ren X, Mahdi MY, Shackleford GM, Erdreich-Epstein A., Free PMC Article | 10/31/2020 |
| G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy. | G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.
Lai S, Fu X, Yang S, Zhang S, Lin Q, Zhang M, Chen H., Free PMC Article | 10/24/2020 |