| Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice. | Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice.
Latt KZ, Yoshida T, Shrivastav S, Abedini A, Reece JM, Sun Z, Lee H, Okamoto K, Dagur P, Ishimoto Y, Heymann J, Zhao Y, Chung JY, Hewitt S, Jose PA, Lee K, He JC, Winkler CA, Knepper MA, Kino T, Rosenberg AZ, Susztak K, Kopp JB. | 10/2/2024 |
| A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment. | A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment.
Asia LK, Van Vuren EJ, Lindeque Z, Williams ME., Free PMC Article | 06/21/2024 |
| Viral protein R (Vpr)-induced neuroinflammation and its potential contribution to neuronal dysfunction: a scoping review. | Viral protein R (Vpr)-induced neuroinflammation and its potential contribution to neuronal dysfunction: a scoping review.
Williams ME, Williams AA, Naudé PJW., Free PMC Article | 08/9/2023 |
| HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein. | HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
Fabryova H, Kao S, Sukegawa S, Miyagi E, Taylor L, Ferhadian D, Saito H, Schaal H, Hillebrand F, Strebel K., Free PMC Article | 03/2/2023 |
| Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development. | Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development.
Chen Y, Chen Y, Fu J, Sun Z, Li H, Xiao W, E J, Lo BY, Wang N, Zhang W, Klotman ME, Klotman PE, Kopp JB, D'Agati VD, He JC, Lee K., Free PMC Article | 02/27/2023 |
| Genetic Analysis of HIV-1 vpr Sequences from HIV-Infected Older Patients on Long-Term Antiretroviral Therapy. | Genetic Analysis of HIV-1 vpr Sequences from HIV-Infected Older Patients on Long-Term Antiretroviral Therapy.
Love M, Samora L, Barker D, Zukosky P, Kummet N, Ahmad A, Bernhardt D, Tripathi M, Klotz S, Ahmad N. | 11/12/2022 |
| Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A. | Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A.
Byeon IL, Calero G, Wu Y, Byeon CH, Jung J, DeLucia M, Zhou X, Weiss S, Ahn J, Hao C, Skowronski J, Gronenborn AM., Free PMC Article | 01/1/2022 |
| Viral protein R polymorphisms in the pathogenesis of HIV-associated acute ischaemic stroke: a case-control study. | Viral protein R polymorphisms in the pathogenesis of HIV-associated acute ischaemic stroke: a case-control study.
McMullen K, Bateman K, Stanley A, Combrinck M, Engelbrecht S, Bryer A. | 12/11/2021 |
| HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4(+) T Cells Early Postinfection. | HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4(+) T Cells Early Postinfection.
Bauby H, Ward CC, Hugh-White R, Swanson CM, Schulz R, Goujon C, Malim MH., Free PMC Article | 11/22/2021 |
| The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr. | The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr.
Dupont L, Bloor S, Williamson JC, Cuesta SM, Shah R, Teixeira-Silva A, Naamati A, Greenwood EJD, Sarafianos SG, Matheson NJ, Lehner PJ., Free PMC Article | 10/23/2021 |
| HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1. | HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.
Zhang Q, Kang Y, Wang S, Gonzalez GM, Li W, Hui H, Wang Y, Rana TM., Free PMC Article | 10/16/2021 |
| Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome. | Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.
Barbosa JAF, Sparapani S, Boulais J, Lodge R, Cohen ÉA., Free PMC Article | 08/28/2021 |
| HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. | HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair.
Li D, Lopez A, Sandoval C, Nichols Doyle R, Fregoso OI., Free PMC Article | 07/17/2021 |
| Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages. | Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages.
Zhao L, Wang S, Xu M, He Y, Zhang X, Xiong Y, Sun H, Ding H, Geng W, Shang H, Liang G., Free PMC Article | 07/10/2021 |
| Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. | Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination.
Eldin P, Péron S, Galashevskaya A, Denis-Lagache N, Cogné M, Slupphaug G, Briant L., Free PMC Article | 07/10/2021 |
| Analysis of Vpr Genetic Variations between Chinese Major Circulating Recombinants CRF01_AE and CRF07_BC. | Analysis of Vpr Genetic Variations between Chinese Major Circulating Recombinants CRF01_AE and CRF07_BC.
Du L, Wang L, Yu T, Xin R, Meng Z. | 07/3/2021 |
| HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137. | HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.
Zhang F, Bieniasz PD., Free PMC Article | 04/17/2021 |
| HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-kappaB/IRF3 nuclear transport. | HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport.
Khan H, Sumner RP, Rasaiyaah J, Tan CP, Rodriguez-Plata MT, Van Tulleken C, Fink D, Zuliani-Alvarez L, Thorne L, Stirling D, Milne RS, Towers GJ., Free PMC Article | 04/3/2021 |
| HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing. | HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing.
Forouzanfar F, Ali S, Wallet C, De Rovere M, Ducloy C, El Mekdad H, El Maassarani M, Aït-Ammar A, Van Assche J, Boutant E, Daouad F, Margottin-Goguet F, Moog C, Van Lint C, Schwartz C, Rohr O., Free PMC Article | 11/21/2020 |
| The data demonstrate that during HIV-1 infection of CD4 T cells, incoming Vpr acts to inhibit the autophagy process activated during viral entry to 'prepare' the cells for an ef fi cient viral replication by decreasing the expression of three autophagy proteins: LC3, Beclin-1 and BNIP3, at their transcriptional level. | HIV-1 Vpr inhibits autophagy during the early steps of infection of CD4 T cells.
Alfaisal J, Machado A, Galais M, Robert-Hebmann V, Arnauné-Pelloquin L, Espert L, Biard-Piechaczyk M. | 04/11/2020 |
| data imply that HIV-1 Vpr uses additional, yet to be identified mechanisms to facilitate HIV-1 replication in T cells. | HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells.
Yan J, Shun MC, Zhang Y, Hao C, Skowronski J., Free PMC Article | 03/21/2020 |
| HIV-1 Vpr strongly inhibited retrotransposition without inhibiting L1 promoter activity. The inhibitory effect of a mutant Vpr (H71R), which is unable to arrest the cell cycle, was significantly relieved compared with that of wild-type Vpr, suggesting that Vpr suppresses L1 mobility in a cell cycle dependent manner. Vpr and p21 coimmunoprecipitated with L1 ORF2p and suppressed the L1 reverse transcriptase activity. | HIV-1 Vpr and p21 restrict LINE-1 mobility.
Kawano K, Doucet AJ, Ueno M, Kariya R, An W, Marzetta F, Kuroki M, Turelli P, Sukegawa S, Okada S, Strebel K, Trono D, Ariumi Y., Free PMC Article | 07/13/2019 |
| We show that HIV-1 Vpr recruits Exo1 to the CRL4(DCAF1) E3 complex for ubiquitination and subsequent proteasome-dependent degradation and that Exo1 levels are depleted in HIV-1-infected cells in a Vpr-dependent manner. | HIV-1 Vpr Reprograms CLR4(DCAF1) E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection.
Yan J, Shun MC, Hao C, Zhang Y, Qian J, Hrecka K, DeLucia M, Monnie C, Ahn J, Skowronski J., Free PMC Article | 04/13/2019 |
| HIV-1 Vpr degrades TET2 by CRL4 E3 ligase to sustain IL-6 expression to enhance viral replication and disease progression. | Vpr Targets TET2 for Degradation by CRL4(VprBP) E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication.
Lv L, Wang Q, Xu Y, Tsao LC, Nakagawa T, Guo H, Su L, Xiong Y., Free PMC Article | 03/9/2019 |
| The HIV-1 accessory protein viral protein R (Vpr) localized to the centrosome through binding to DCAF1, forming a complex with the ubiquitin ligase EDD-DYRK2-DDB1(DCAF1) and Cep78, a resident centrosomal protein previously shown to inhibit EDD-DYRK2-DDB1(DCAF1) Vpr did not affect ubiquitination of Cep78. It enhanced ubiquitination of an EDD-DYRK2-DDB1(DCAF1) substrate, CP110, leading to its degradation. | HIV-1 Vpr hijacks EDD-DYRK2-DDB1(DCAF1) to disrupt centrosome homeostasis.
Hossain D, Ferreira Barbosa JA, Cohen ÉA, Tsang WY., Free PMC Article | 01/26/2019 |