| The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells. | The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells.
Almestica-Roberts M, Nguyen ND, Sun L, Serna SN, Rapp E, Burrell-Gerbers KL, Memon TA, Stone BL, Nkoy FL, Lamb JG, Deering-Rice CE, Rower JE, Reilly CA., Free PMC Article | 08/14/2024 |
| Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients. | Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients.
Incze E, Mangó K, Fekete F, Kiss ÁF, Póti Á, Harkó T, Moldvay J, Szüts D, Monostory K., Free PMC Article | 11/18/2023 |
| Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F). | Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F).
Lee YB, Kim V, Lee SG, Lee GH, Kim C, Jeong E, Kim D., Free PMC Article | 06/7/2023 |
| CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients. | CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients.
Dalle Fratte C, Gagno S, Roncato R, Polesel J, Zanchetta M, Buzzo M, Posocco B, De Mattia E, Borsatti R, Puglisi F, Foltran L, Guardascione M, Buonadonna A, Cecchin E, Toffoli G. | 02/16/2023 |
| CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage. | CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
Li Y, You C, Liu Z, He F, Zhao F, Song X, Xie Z, Wei S, Yang Y, Wei H, Che F, Yu J. | 02/15/2023 |
| [Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome]. | [Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome].
Muradian AA, Sychev DA, Blagovestnov DA, Petrov DI, Skukin DS, Epifanova IP, Sozaeva ZA, Kachanova AA, Denisenko NP, Abdullaev SP, Grishina EA. | 11/5/2022 |
| The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility. | The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility.
Qu W, Zhang F, Cheng Y, Li J, Zhou J., Free PMC Article | 10/29/2022 |
| The anti-inflammatory role of placental Hofbauer cells is altered in patients with chorioamnionitis: Are CYP2C8 and soluble epoxide hydrolase involved in immunomodulation? | The anti-inflammatory role of placental Hofbauer cells is altered in patients with chorioamnionitis: Are CYP2C8 and soluble epoxide hydrolase involved in immunomodulation?
Tauber Z, Cizkova K. | 10/1/2022 |
| Variability of CYP2C8 Polymorphisms in Three Jordanian Populations: Circassians, Chechens and Jordanian-Arabs. | Variability of CYP2C8 Polymorphisms in Three Jordanian Populations: Circassians, Chechens and Jordanian-Arabs.
Abudahab S, Hakooz N, Tobeh N, Gogazeh E, Gharaibeh M, Al-Eitan L, Zihlif M, Dajani R. | 08/27/2022 |
| The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals. | The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals.
Haeggström S, Ingelman-Sundberg M, Pääbo S, Zeberg H., Free PMC Article | 08/20/2022 |
| CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project. | CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project.
Gaedigk A, Boone EC, Scherer SE, Lee SB, Numanagić I, Sahinalp C, Smith JD, McGee S, Radhakrishnan A, Qin X, Wang WY, Farrow EG, Gonzaludo N, Halpern AL, Nickerson DA, Miller NA, Pratt VM, Kalman LV., Free PMC Article | 04/9/2022 |
| Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment. | Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment.
Yamoune S, Wintz K, Niederau C, Craveiro RB, Wolf M, Stingl J. | 03/19/2022 |
| CYP2C8 and CYP2E1 genetic variants increase risk of tuberculosis in northwest Chinese Han population. | CYP2C8 and CYP2E1 genetic variants increase risk of tuberculosis in northwest Chinese Han population.
Xing S, Wang Y, He X, Yang W, Hu Q, He Y, Yuan D, Jin T. | 03/19/2022 |
| CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer. | CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer.
Li K, Chen Y., Free PMC Article | 10/16/2021 |
| Influence of CYP2C8, CYP3A4, and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax. | Influence of CYP2C8, CYP3A4, and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax.
Almeida ACG, Puça MCB, Figueiredo EFG, Barbosa LR, Salazar YEAR, Silva EL, Brito MAM, Siqueira AM, Vieira JLF, Lacerda MVG, Monteiro WM, Melo GC., Free PMC Article | 07/3/2021 |
| Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance. | Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance.
Hofman J, Vagiannis D, Chen S, Guo L. | 04/24/2021 |
| CYP3A5*3 and CYP2C8*3 variants influence exposure and clinical outcomes of tacrolimus-based therapy. | CYP3A5*3 and CYP2C8*3 variants influence exposure and clinical outcomes of tacrolimus-based therapy.
Genvigir FDV, Campos-Salazar AB, Felipe CR, Tedesco-Silva H Jr, Medina-Pestana JO, Doi SQ, Cerda A, Hirata MH, Herrero MJ, Aliño SF, Hirata RDC. | 09/26/2020 |
| These results suggest a subset of individuals with genetic variation in CYP2C8 and CYP2C9 recognize that they obtain adequate drug efficacy with lower ibuprofen doses, or take lower doses due to prior side effects. | Individuals with CYP2C8 and CYP2C9 reduced metabolism haplotypes self-adjusted ibuprofen dose in the Coriell Personalized Medicine Collaborative.
Zajic SC, Jarvis JP, Zhang P, Rajula KD, Brangan A, Brenner R, Dempsey MP, Christman MF. | 03/7/2020 |
| Contrary to previous publications, CYP2C8*3 may confer increased paclitaxel metabolic activity. SLCO1B1 and CYP2C8 genotype may explain some paclitaxel pharmacokinetic variability. | Patients carrying CYP2C8*3 have shorter systemic paclitaxel exposure.
Marcath LA, Kidwell KM, Robinson AC, Vangipuram K, Burness ML, Griggs JJ, Poznak CV, Schott AF, Hayes DF, Henry NL, Hertz DL., Free PMC Article | 02/29/2020 |
| There are naturally occurring polymorphisms, CYP2C8*2 and CYP2C8*3, that display altered paclitaxel hydroxylation rates despite these mutations not being located in the active site. Anaerobic stopped-flow measurements determined that these polymorphisms have altered first electron transfer kinetics, compared to CYP2C8*1 (wildtype), that suggest electron transfer from cytochrome P450 reductase (CPR) is disfavored. | Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling.
R Arnold W, Zelasko S, D Meling D, Sam K, Das A., Free PMC Article | 02/8/2020 |
| Not in HLMs or other recombinant CYP2C8 preparations. | Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.
Kahma H, Filppula AM, Launiainen T, Viinamäki J, Neuvonen M, Evangelista EA, Totah RA, Backman JT., Free PMC Article | 01/25/2020 |
| CYP2C8 plays a critical role in the formation of 3-hydroxydesloratadine in humans. | Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT. | 01/25/2020 |
| The effect of CKD on CYP1A2, CYP2C9, and CYP2C19 was variable and modest compared to CYP2C8 and OATP. | Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP.
Tan ML, Yoshida K, Zhao P, Zhang L, Nolin TD, Piquette-Miller M, Galetin A, Huang SM., Free PMC Article | 05/25/2019 |
| Single Nucleotide Polymorphism in CYP2C8 , which synthesize epoxyeicosatrienoic acids, may modify Cardiovascular outcomes in Renal Transplant recipients. | Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients.
Gervasini G, Luna E, Garcia-Pino G, Azevedo L, Mota-Zamorano S, José Cubero J. | 04/20/2019 |
| In the villous trophoblast, CYP2C8 was the most abundant protein. Its expression is higher than the CYP2C9 and CYP2J2 in the cytotrophoblast in the embryonic stage of development and remains higher in syncytiotrophoblast of term placenta. | Time-dependent expression pattern of cytochrome P450 epoxygenases and soluble epoxide hydrolase in normal human placenta.
Cizkova K, Tauber Z. | 11/10/2018 |