| SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling. | SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling.
Liu Z, Bian X, Li L, Liu L, Feng C, Wang Y, Ni J, Li S, Lu D, Li Y, Ma C, Yu T, Xiao X, Xue N, Wang Y, Zhang C, Ma X, Gao X, Fan X, Liu X, Fan G., Free PMC Article | 10/2/2024 |
| ClassIIb histone deacetylase participates in perioperative neurocognitive disorders in elderly mice via HSP90/GR signaling pathway. | ClassIIb histone deacetylase participates in perioperative neurocognitive disorders in elderly mice via HSP90/GR signaling pathway.
Liu Y, Wang X, Wang J, Jin Q, Cai W, Pan C, Nivar J, Tao Y, Cao H, Li J. | 08/30/2024 |
| Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis. | Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis.
Xing Y, Li P, Jia Y, Zhang K, Liu M, Jiang J., Free PMC Article | 08/9/2024 |
| [Age-dependent expression of HSP90 in the hippocampus of APP/PS1 mice]. | [Age-dependent expression of HSP90 in the hippocampus of APP/PS1 mice].
Wang BY, Liu SY, Hao KM, Qi WX. | 04/29/2024 |
| Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity. | Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity.
Li J, Han X, Sun M, Li W, Yang G, Chen H, Guo B, Li J, Li X, Wang H., Free PMC Article | 12/18/2023 |
| The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation. | The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation.
Chen DD, Liu B, Wang Y, Jiang M, Shang G, Xue M, Jia X, Lang Y, Zhou G, Zhang F, Peng X, Hu Y. | 02/28/2023 |
| HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma. | HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma.
Zhang H, Yin X, Zhang X, Zhou M, Xu W, Wei Z, Song C, Han S, Han W., Free PMC Article | 08/27/2022 |
| Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. | Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain.
Wang Y, Scarneo SA, Kim SH, Zhang X, Chen J, Yang KW, Hughes P, Haystead T, Nackley AG., Free PMC Article | 05/21/2022 |
| Inhibition of Heat Shock Protein 90 Attenuates the Damage of Blood-Brain Barrier Integrity in Traumatic Brain Injury Mouse Model. | Inhibition of Heat Shock Protein 90 Attenuates the Damage of Blood-Brain Barrier Integrity in Traumatic Brain Injury Mouse Model.
Zhang JM, Jing Y, Wang K, Jiao JT, Xu JY, Shi J, Ji DD, Lu SR, Li XD, Zhang Y, Cao XD., Free PMC Article | 04/30/2022 |
| Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1alpha Signaling. | Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling.
Chen B, Yang B, Zhu J, Wu J, Sha J, Sun J, Bao E, Zhang X., Free PMC Article | 11/28/2020 |
| The results demonstrate that in renal cells, NHE1 is associated with several regulatory proteins including Hsp90, and that Hsp90 affects its function possibly through altered phosphorylation of the protein via the AKT kinase. | Protein mediated regulation of the NHE1 isoform of the Na(+)/H(+) exchanger in renal cells. A regulatory role of Hsp90 and AKT kinase.
Odunewu-Aderibigbe A, Fliegel L. | 03/10/2018 |
| Extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, are responsible for tumor induction of cachexia. | Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90.
Zhang G, Liu Z, Ding H, Zhou Y, Doan HA, Sin KWT, Zhu ZJ, Flores R, Wen Y, Gong X, Liu Q, Li YP., Free PMC Article | 02/3/2018 |
| a surface population of Hsp90 extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta-activated fibroblasts. | Extracellular heat shock protein 90 binding to TGFβ receptor I participates in TGFβ-mediated collagen production in myocardial fibroblasts.
García R, Merino D, Gómez JM, Nistal JF, Hurlé MA, Cortajarena AL, Villar AV. | 12/2/2017 |
| Hsp90 is highly expressed on the cell surface of melanoma cells, and synthetic agents that target Hsp90 are promising cancer therapeutic drugs | The Ig V(H) complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor.
Girola N, Matsuo AL, Figueiredo CR, Massaoka MH, Farias CF, Arruda DC, Azevedo RA, Monteiro HP, Resende-Lara PT, Cunha RL, Polonelli L, Travassos LR. | 12/2/2017 |
| These findings identify the Ezh2-Hsp90 interaction as a previously unrecognized mechanism essential for T-cell responses and an effective target for controlling graft-versus-host disease. | Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice.
Huang Q, He S, Tian Y, Gu Y, Chen P, Li C, Huang J, Liu Y, Yu H, Jin M, Hu S, Tong Q, Ma A, Jin J, Hexner E, Fung H, Reshef R, Zhang Y, Zhang Y., Free PMC Article | 09/16/2017 |
| Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer. | Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer.
Le B, Powers GL, Tam YT, Schumacher N, Malinowski RL, Steinke L, Kwon G, Marker PC., Free PMC Article | 09/2/2017 |
| genes respond to HSP90 inhibition in a manner dependent on their genomic location with regard to strain-specific endogenous retroviruses-insertion sites. | The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses.
Hummel B, Hansen EC, Yoveva A, Aprile-Garcia F, Hussong R, Sawarkar R. | 06/24/2017 |
| PABPN1 interacts with and is stabilized by heat shock protein 90. | The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein.
Shi C, Huang X, Zhang B, Zhu D, Luo H, Lu Q, Xiong WC, Mei L, Luo S., Free PMC Article | 06/11/2016 |
| Hyperacetylation of Hsp90 is a predictor and causal molecular determinant of stress resilience in mice. Brain-penetrant histone deacetylase 6 inhibitors increase Hsp90 acetylation and modulate GR chaperone dynamics. | Enhancement of stress resilience through histone deacetylase 6-mediated regulation of glucocorticoid receptor chaperone dynamics.
Jochems J, Teegarden SL, Chen Y, Boulden J, Challis C, Ben-Dor GA, Kim SF, Berton O., Free PMC Article | 05/21/2016 |
| These findings demonstrate a critical role of Hsp90 in lipopolysaccharide (LPS) signaling, and a potential involvement of the heat shock response in LPS-induced preconditioning. | LPS-induced delayed preconditioning is mediated by Hsp90 and involves the heat shock response in mouse kidney.
Kaucsár T, Bodor C, Godó M, Szalay C, Révész C, Németh Z, Mózes M, Szénási G, Rosivall L, Sőti C, Hamar P., Free PMC Article | 12/19/2015 |
| Phosphoproteomics, protein expression inference and signaling pathway prediction analysis of P2RX7 signaling mediators pointed to HSPA2 and HSP90 proteins. | A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
Young CN, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, Gorecki DC., Free PMC Article | 11/21/2015 |
| Hsp90 inhibition plays a key role in preventing the recurrence of HCC, and the combination of ablation with targeted therapy holds great potential to improve prognosis and survival of HCC patients. | Tumour eradication using synchronous thermal ablation and Hsp90 chemotherapy with protein engineered triblock biopolymer-geldanamycin conjugates.
Chen Y, Youn P, Pysher TJ, Scaife CL, Furgeson DY. | 08/1/2015 |
| These findings demonstrate CKII induces polymerization of soluble TDP-43 into filaments and Hsp90 promotes TDP-43 filament depolymerization. | Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.
Carlomagno Y, Zhang Y, Davis M, Lin WL, Cook C, Dunmore J, Tay W, Menkosky K, Cao X, Petrucelli L, Deture M., Free PMC Article | 02/14/2015 |
| Data show that the heat shock protein 90 (HSP90) isoforms HSP90AA1 and HSP90AB1 are responsible for maintaining proper cellular levels of BMAL1 protein. | HSP90 affects the stability of BMAL1 and circadian gene expression.
Schneider R, Linka RM, Reinke H. | 12/20/2014 |
| Reveal an opposite role of Hsp70 and Hsp90 in regulating TGF-beta signaling by implicating CHIP-mediated Smad3 ubiquitination and degradation. This study provides a new insight into understanding the regulation of the TGF-beta signaling by chaperones. | Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1.
Shang Y, Xu X, Duan X, Guo J, Wang Y, Ren F, He D, Chang Z. | 06/14/2014 |