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    CYP1B1 cytochrome P450 family 1 subfamily B member 1 [ Homo sapiens (human) ]

    Gene ID: 1545, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner.

    Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner.
    Chen H, Cheng Z, Wang M, Huang Q, Zheng D, Huang Q, Cai K.

    04/4/2024
    Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study.

    Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study.
    Datkhile KD, Patil SR, Patil MN, Durgawale PP, Jagdale NJ, Deshmukh VN, More AL, Gudur RA, Gudur AK.

    03/27/2024
    CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.

    CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.
    Wu J, Li Y, Tian S, Na S, Wei H, Wu Y, Yang Y, Shen Z, Ding J, Bao S, Liu S, Li L, Feng R, Zhu Y, He C, Yue J., Free PMC Article

    03/14/2024
    Variable Phenotype of Congenital Corneal Opacities in Biallelic CYP1B1 Pathogenic Variants.

    Variable Phenotype of Congenital Corneal Opacities in Biallelic CYP1B1 Pathogenic Variants.
    Franco E, Gagrani M, Scanga HL, Areaux RG Jr, Chu CT, Nischal KK.,

    01/5/2024
    Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.

    Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.
    Kwon YJ, Kwon TU, Shin S, Lee B, Lee H, Park H, Kim D, Moon A, Chun YJ.

    11/16/2023
    Genotyping of the rs1800440 Polymorphism in CYP1B1 Gene and the rs9258883 Polymorphism in HLA-B Gene in a Spanish Cohort of 223 Patients with Frontal Fibrosing Alopecia.

    Genotyping of the rs1800440 Polymorphism in CYP1B1 Gene and the rs9258883 Polymorphism in HLA-B Gene in a Spanish Cohort of 223 Patients with Frontal Fibrosing Alopecia.
    Saceda-Corralo D, Ortega-Quijano D, Muñoz-Martín G, Moreno-Arrones ÓM, Pindado-Ortega C, Rayinda T, Melián-Olivera A, Azcárraga-Llobet C, Burgos-Blasco P, Castañeda-Bermúdez ME, Del Castillo FJ, Vañó-Galván S., Free PMC Article

    09/28/2023
    Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells.

    Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells.
    Lin YC, Cheung G, Zhang Z, Papadopoulos V., Free PMC Article

    09/18/2023
    ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.

    ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.
    Ye G, Li J, Yu W, Xie Z, Zheng G, Liu W, Wang S, Cao Q, Lin J, Su Z, Li D, Che Y, Fan S, Wang P, Wu Y, Shen H., Free PMC Article

    09/8/2023
    Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.

    Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.
    Dutkiewicz Z, Mikstacka R., Free PMC Article

    08/19/2023
    Human Adult Renal Progenitor Cells Prevent Cisplatin-Nephrotoxicity by Inducing CYP1B1 Overexpression and miR-27b-3p Down-Regulation through Extracellular Vesicles.

    Human Adult Renal Progenitor Cells Prevent Cisplatin-Nephrotoxicity by Inducing CYP1B1 Overexpression and miR-27b-3p Down-Regulation through Extracellular Vesicles.
    Franzin R, Stasi A, De Palma G, Picerno A, Curci C, Sebastiano S, Campioni M, Cicirelli A, Rizzo A, Di Lorenzo VF, Pontrelli P, Pertosa GB, Castellano G, Gesualdo L, Sallustio F., Free PMC Article

    07/5/2023
    CYP1B1 Genetic Variants (rs10916 and rs2855658) Are Associated with Increased Risk of Ischemic Stroke in Chinese Han Population.

    CYP1B1 Genetic Variants (rs10916 and rs2855658) Are Associated with Increased Risk of Ischemic Stroke in Chinese Han Population.
    Zhang F, Fu C, Deng Y, Zhang M, Peng H, Li W, Zhong J, Zhou Q, Huang L, Xiao S, Zhao J.

    06/1/2023
    CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma.

    CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma.
    Kaushik S, Luthra-Guptasarma M, Prasher D, Dhingra D, Singh N, Kumar A, Sharma SP, Kaur H, Snehi S, Thattaruthody F, Pandav SS.

    02/11/2023
    Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells.

    Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells.
    Chen Y, Lu Z, Li B, Wang H, Jiang T, Xuan M, Yang H, Chen J, Liu X, Liang H, Liu Y, Tang H.

    01/14/2023
    Mutation screening of the CYP1B1 gene reveals thirteen novel disease-causing variants in consanguineous Pakistani families causing primary congenital glaucoma.

    Mutation screening of the CYP1B1 gene reveals thirteen novel disease-causing variants in consanguineous Pakistani families causing primary congenital glaucoma.
    Tehreem R, Arooj A, Siddiqui SN, Naz S, Afshan K, Firasat S., Free PMC Article

    10/1/2022
    Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death.

    Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death.
    Kim YJ, Park JE, Chung JY, Kim JY, Lee SG, Lee SJ, Yu WJ, Kim HY, Kim HJ, Koh H, Bae HR, Yoo YH, Kim JM.

    08/6/2022
    Polymorphisms in CYP1B1 gene and the risk of suffering Primary Open-Angle Glaucoma: Systematic review and meta-analysis.

    Polymorphisms in CYP1B1 gene and the risk of suffering Primary Open-Angle Glaucoma: Systematic review and meta-analysis.
    Calero-Dueñas N, Mateos-Olivares M, Ussa F, Juberías JR, Marcos M, Pastor-Idoate S, Usategui-Martín R.

    07/23/2022
    Neonatal-Onset Congenital Ectropion Uveae May Be Caused by a Distinct CYP1B1 Pathologic Variant.

    Neonatal-Onset Congenital Ectropion Uveae May Be Caused by a Distinct CYP1B1 Pathologic Variant.
    Kaushik S, Choudhary S, Kaur A, Srivastava P, Pokharel B, Akella M, Pandav SS.

    06/25/2022
    CYP1B1-catalyzed 4-OHE2 promotes the castration resistance of prostate cancer stem cells by estrogen receptor alpha-mediated IL6 activation.

    CYP1B1-catalyzed 4-OHE2 promotes the castration resistance of prostate cancer stem cells by estrogen receptor α-mediated IL6 activation.
    Lin Q, Cao J, Du X, Yang K, Yang X, Liang Z, Shi J, Zhang J., Free PMC Article

    05/14/2022
    CYP1B1-AS1 Is a Novel Biomarker in Glioblastoma by Comprehensive Analysis.

    CYP1B1-AS1 Is a Novel Biomarker in Glioblastoma by Comprehensive Analysis.
    Ye T, Li LL, Peng XM, Li Q., Free PMC Article

    04/2/2022
    Genome-wide evaluation of transcriptomic responses of human tissues to smoke: A systems biology study.

    Genome-wide evaluation of transcriptomic responses of human tissues to smoke: A systems biology study.
    Sohrabi SS, Rashidipour M, Sohrabi SM, Hadizadeh M, Shams MH, Mohammadi M.

    03/26/2022
    Association of genetic polymorphisms with local steroid metabolism in human benign breasts.

    Association of genetic polymorphisms with local steroid metabolism in human benign breasts.
    Lee O, Fought AJ, Shidfar A, Heinz RE, Kmiecik TE, Gann PH, Khan SA, Chatterton RT.

    03/5/2022
    Biological and Clinical Implications of TNF-alpha Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility.

    Biological and Clinical Implications of TNF-α Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility.
    Mir R, Elfaki I, Jha CK, Javid J, Babakr AT, Banu S, Mir MM, Jamwal D, Khullar N, Alzahrani KJ, Chahal SMS.

    02/5/2022
    Novel compound heterozygous mutations in CYP1B1 identified in a Chinese family with developmental glaucoma.

    Novel compound heterozygous mutations in CYP1B1 identified in a Chinese family with developmental glaucoma.
    Cai S, Zhang D, Jiao X, Wang T, Fan M, Wang Y, Hejtmancik JF, Liu X., Free PMC Article

    01/22/2022
    Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation.

    Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation.
    Lu Y, Nanayakkara G, Sun Y, Liu L, Xu K, Drummer C 4th, Shao Y, Saaoud F, Choi ET, Jiang X, Wang H, Yang X., Free PMC Article

    12/18/2021
    Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.

    Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
    Al-Saraireh YM, Alshammari FOFO, Youssef AMM, Al-Sarayreh S, Almuhaisen GH, Alnawaiseh N, Al Shuneigat JM, Alrawashdeh HM., Free PMC Article

    12/11/2021
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