| Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition. | Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition.
Alghoul F, Laure S, Eriani G, Martin F., Free PMC Article | 10/23/2021 |
| HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation. | HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation.
Bridoux L, Zarrineh P, Mallen J, Phuycharoen M, Latorre V, Ladam F, Losa M, Baker SM, Sagerstrom C, Mace KA, Rattray M, Bobola N., Free PMC Article | 01/23/2021 |
| HoxA3 induced upregulation of Jag1 ligand in endothelial cells, which led to cis-inhibition of the Notch pathway, rendering the HE nonresponsive to Notch signals. | Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.
Sanghez V, Luzzi A, Clarke D, Kee D, Beuder S, Rux D, Osawa M, Madrenas J, Chou TF, Kyba M, Iacovino M., Free PMC Article | 11/4/2017 |
| Our findings suggest a role for Hox a3 protein activity in promoting M1-to-M2-like phenotypic switching via interactions with myeloid transcription factors and provide insight into mechanisms regulating this process in diabetic wound healing | Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo.
Al Sadoun H, Burgess M, Hentges KE, Mace KA., Free PMC Article | 08/12/2017 |
| ultiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. | Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.
Chojnowski JL, Masuda K, Trau HA, Thomas K, Capecchi M, Manley NR., Free PMC Article | 11/29/2014 |
| Studies indicate that Hoxa3 promotes proliferation and differentiation of HSC/Ps into Gr-1+CD11b+ myeloid cells. | Hoxa3 promotes the differentiation of hematopoietic progenitor cells into proangiogenic Gr-1+CD11b+ myeloid cells.
Mahdipour E, Charnock JC, Mace KA. | 04/16/2011 |
| Data show that HoxA3 restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells. | HoxA3 is an apical regulator of haemogenic endothelium.
Iacovino M, Chong D, Szatmari I, Hartweck L, Rux D, Caprioli A, Cleaver O, Kyba M., Free PMC Article | 03/5/2011 |
| demonstrate that zebrafish hoxa3a (zfhoxa3a) expressed from the mouse Hoxa3 locus can substitute for mouse Hoxa3 in some tissues, but has distinct or null phenotypes in others. | Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function.
Chen L, Zhao P, Wells L, Amemiya CT, Condie BG, Manley NR., Free PMC Article | 07/26/2010 |
| HOXA3 accelerates wound repair by mobilizing endothelial progenitor cells and attenuating the excessive inflammatory response of chronic wounds. | HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells.
Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ., Free PMC Article | 01/21/2010 |
| homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos | Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos.
Kameda Y, Nishimaki T, Takeichi M, Chisaka O. | 01/21/2010 |
| Results suggest that members of the Hox groups (Hoxa3, Hoxb3, Hoxd3) coordinate both suppression and activation mechanisms that ensure distinction between the multiple rhombomeres in the developing hindbrain. | Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons.
Gaufo GO, Thomas KR, Capecchi MR. | 01/21/2010 |
| Hoxa3 gene is crucial for the formation of the common carotid artery and the null mutant mice are the first useful animal models to show that the third arch arteries on both sides specifically degenerate but the fourth and sixth arch arteries are normal | Disruption of the Hoxa3 homeobox gene results in anomalies of the carotid artery system and the arterial baroreceptors.
Kameda Y, Watari-Goshima N, Nishimaki T, Chisaka O. | 01/21/2010 |
| The proximal 2-kb of the Hoxa3 promoter directs gene expression in distinct branchial compartments and cranial ganglia. | The proximal 2-kb of the Hoxa3 promoter directs gene expression in distinct branchial compartments and cranial ganglia.
Diman NY, Chauvier E, Pacico N, Picard JJ, Rezsohazy R. | 01/21/2010 |
| Dual origins of the carotid body revealed by targeted disruption of Hoxa3 and Mash1. | Dual origins of the mouse carotid body revealed by targeted disruption of Hoxa3 and Mash1.
Kameda Y. | 01/21/2010 |
| Hoxa3 regulates the proliferation and differentiation of the 3rd pharyngeal arch mesoderm. | Hoxa3 regulates the proliferation and differentiation of the third pharyngeal arch mesenchyme in mice.
Chisaka O, Kameda Y. | 01/21/2010 |
| HOXA3 can facilitate tissue remodeling via coordinated changes in both epithelial and endothelial cell gene expression and behavior in adult tissues during wound repair. | HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair.
Mace KA, Hansen SL, Myers C, Young DM, Boudreau N. | 01/21/2010 |