| HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation. | HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation.
Bridoux L, Zarrineh P, Mallen J, Phuycharoen M, Latorre V, Ladam F, Losa M, Baker SM, Sagerstrom C, Mace KA, Rattray M, Bobola N., Free PMC Article | 01/23/2021 |
| Study demonstrates that Hoxa-2 protein express in all ossicular blastemata of the mouse embryo, which could suggest a contribution of second arch cells to the entire ossicular chain. | Hox-A2 protein expression in mouse embryo middle ear ossicles.
Louryan S, Lejong M, Choa-Duterre M, Vanmuylder N. | 03/23/2019 |
| These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit. | Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.
Karmakar K, Narita Y, Fadok J, Ducret S, Loche A, Kitazawa T, Genoud C, Di Meglio T, Thierry R, Bacelo J, Lüthi A, Rijli FM. | 11/25/2017 |
| Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression. | A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex.
Rosin JM, Li W, Cox LL, Rolfe SM, Latorre V, Akiyama JA, Visel A, Kuramoto T, Bobola N, Turner EE, Cox TC., Free PMC Article | 09/9/2017 |
| our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm. | KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity.
Bridoux L, Bergiers I, Draime A, Halbout M, Deneyer N, Twizere JC, Rezsohazy R. | 12/19/2015 |
| Ectopic Hoxa2 expression results in the transformation of the proximal Meckel's cartilage and the malleus into a supernumerary styloid process (SP), a second pharyngeal arch-derived mammalian-specific skeletal structure. | Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.
Kitazawa T, Fujisawa K, Narboux-Nême N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H. | 08/15/2015 |
| Hoxa2 operates as a tissue-specific cofactor, enhancing Meis binding to specific sites that provide the second arch with its anatomical identity | Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.
Amin S, Donaldson IJ, Zannino DA, Hensman J, Rattray M, Losa M, Spitz F, Ladam F, Sagerström C, Bobola N., Free PMC Article | 04/18/2015 |
| The impairment of chondrogenic differentiation by Hoxa2 overexpression. | Molecular study of a Hoxa2 gain-of-function in chondrogenesis: a model of idiopathic proportionate short stature.
Deprez PM, Nichane MG, Lengelé BG, Rezsöhazy R, Nyssen-Behets C., Free PMC Article | 04/26/2014 |
| Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch. | Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.
Anderson M, Amin S, Luise F, Zeef L, Bobola N., Free PMC Article | 12/28/2013 |
| Hoxa2 partly controls the morphogenesis of the pinna through the BMP signalling pathway and expression of Eya1, which in humans is involved in branchio-oto-renal syndrome. | Mouse Hoxa2 mutations provide a model for microtia and auricle duplication.
Minoux M, Kratochwil CF, Ducret S, Amin S, Kitazawa T, Kurihara H, Bobola N, Vilain N, Rijli FM. | 12/14/2013 |
| Hoxb2 antagonizes Hoxa2 during rostral hindbrain oligodendrogenesis. | Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning.
Miguez A, Ducret S, Di Meglio T, Parras C, Hmidan H, Haton C, Sekizar S, Mannioui A, Vidal M, Kerever A, Nyabi O, Haigh J, Zalc B, Rijli FM, Thomas JL., Free PMC Article | 02/23/2013 |
| the sustained expression of Hoxa2 in the chondrocyte lineage is characterized by a proportionate short stature resulting from skeletal growth defect. | Postnatal growth defect in mice upon persistent Hoxa2 expression in the chondrogenic cell lineage.
Deprez PM, Nichane MG, Rousseaux P, Devogelaer JP, Chappard D, Lengelé BG, Rezsöhazy R, Nyssen-Behets C. | 09/29/2012 |
| The data reveals that Hoxa2 has large genome coverage and potentially regulates thousands of genes. | Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development.
Donaldson IJ, Amin S, Hensman JJ, Kutejova E, Rattray M, Lawrence N, Hayes A, Ward CM, Bobola N., Free PMC Article | 07/21/2012 |
| The inhibition of miR-3960 expression attenuated the osteoblastogenesis. Homeobox A2 (Hoxa2), a repressor of Runx2 expression, was confirmed to be a target of miR-3960. | A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.
Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH., Free PMC Article | 07/23/2011 |
| Meox1 expression is downregulated in the second arch of Hoxa2 mouse mutant embryos. | Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.
Kirilenko P, He G, Mankoo BS, Mallo M, Jones R, Bobola N., Free PMC Article | 04/23/2011 |
| The Satb2 gene was down-regulated and the Hoxa2 gene was up-regulated in phenytoin-treated mouse embryonic craniofacial tissue. | Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue.
Mao XY, Tang SJ. | 01/1/2011 |
| Results demonstrate the cleft palate phenotype of Hoxa2 null embryos is not solely due to abnormal tongue musculature, and indicate a direct role of Hoxa2 in regulating murine palatogenesis. | Hoxa2 plays a direct role in murine palate development.
Smith TM, Wang X, Zhang W, Kulyk W, Nazarali AJ. | 01/21/2010 |
| Hoxa2-/- mutation leads to the elimination of a transient control of the inspiratory amplitude normally occurring during the first hours following birth. | Distinct roles of Hoxa2 and Krox20 in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw opening.
Chatonnet F, Wrobel LJ, Mézières V, Pasqualetti M, Ducret S, Taillebourg E, Charnay P, Rijli FM, Champagnat J., Free PMC Article | 01/21/2010 |
| propose that Six2 acts to mediate Hoxa2 control over the insulin-like growth factor pathway during branchial arch development | Six2 functions redundantly immediately downstream of Hoxa2.
Kutejova E, Engist B, Self M, Oliver G, Kirilenko P, Bobola N. | 01/21/2010 |
| Hox genes control the neurogenic potential of at least some cranial neural crest cells. | Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice.
Yang X, Zhou Y, Barcarse EA, O'Gorman S. | 01/21/2010 |
| Lmo1 takes part in a Hox paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning | Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.
Matis C, Oury F, Remacle S, Lampe X, Gofflot F, Picard JJ, Rijli FM, Rezsohazy R. | 01/21/2010 |
| although Hoxa2 is expressed throughout oligodendrocyte development, it does not appear to be critical for early stages of oligodendrogenesis in the murine spinal cord | Early stages of oligodendrocyte development in the embryonic murine spinal cord proceed normally in the absence of Hoxa2.
Nicolay DJ, Doucette JR, Nazarali AJ. | 01/21/2010 |
| Hoxa2 displays an anti-chondrogenic activity that is distinct from its patterning function | Expression of Hoxa2 in cells entering chondrogenesis impairs overall cartilage development.
Massip L, Ectors F, Deprez P, Maleki M, Behets C, Lengelé B, Delahaut P, Picard J, Rezsöhazy R. | 01/21/2010 |
| Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region | Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.
Kutejova E, Engist B, Mallo M, Kanzler B, Bobola N. | 01/21/2010 |
| Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element | The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element.
Lampe X, Picard JJ, Rezsohazy R. | 01/21/2010 |